Implication of CD21, CD35, and CD55 in the Pathogenesis of Age-Related Macular Degeneration
Purpose To determine a possible implication of CD21, CD35, and CD55 in the pathogenesis of age-related macular degeneration (AMD) by assessing the difference in expression rates of these factors on AMD patients and a control group. Design Case-control study. Methods Fifty unrelated AMD patients and...
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| Veröffentlicht in: | American journal of ophthalmology 2011-09, Vol.152 (3), p.396-399.e1 |
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| container_title | American journal of ophthalmology |
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| creator | Haas, Paulina Aggermann, Tina Nagl, Manfred Steindl-Kuscher, Kerstin Krugluger, Walter Binder, Susanne |
| description | Purpose To determine a possible implication of CD21, CD35, and CD55 in the pathogenesis of age-related macular degeneration (AMD) by assessing the difference in expression rates of these factors on AMD patients and a control group. Design Case-control study. Methods Fifty unrelated AMD patients and 48 unrelated sex- and age-matched control subjects participated in this case-control study. Samples of fresh EDTA-blood were stained and flow cytometry was chosen to measure fluorescence emissions. The association between exudative AMD and CD21, CD35, and CD55 was evaluated from all patients who completed the study. Results Our study shows CD35 to be expressed in a significantly higher frequency in AMD patients on monocytes ( P = .00586), lymphocytes ( P = .000605), and granulocytes ( P < .000033). In contrast, the expression rate of CD21 ( P > .05) and CD55 ( P > .05) are similar in both groups. Conclusion More regulative factors of the complement system are involved in pathogenesis of AMD. Our study underlines the key role of the complement system in AMD and shows the involvement of the whole immune system through more regulative factors. |
| doi_str_mv | 10.1016/j.ajo.2011.02.017 |
| format | Article |
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Design Case-control study. Methods Fifty unrelated AMD patients and 48 unrelated sex- and age-matched control subjects participated in this case-control study. Samples of fresh EDTA-blood were stained and flow cytometry was chosen to measure fluorescence emissions. The association between exudative AMD and CD21, CD35, and CD55 was evaluated from all patients who completed the study. Results Our study shows CD35 to be expressed in a significantly higher frequency in AMD patients on monocytes ( P = .00586), lymphocytes ( P = .000605), and granulocytes ( P < .000033). In contrast, the expression rate of CD21 ( P > .05) and CD55 ( P > .05) are similar in both groups. Conclusion More regulative factors of the complement system are involved in pathogenesis of AMD. Our study underlines the key role of the complement system in AMD and shows the involvement of the whole immune system through more regulative factors.</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/j.ajo.2011.02.017</identifier><identifier>PMID: 21669404</identifier><identifier>CODEN: AJOPAA</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Arthritis ; Autoimmune diseases ; Biological and medical sciences ; Case-Control Studies ; CD55 Antigens - metabolism ; Diabetic retinopathy ; Disease ; Erythrocytes - metabolism ; Female ; Flow Cytometry ; Fluorescein Angiography ; Humans ; Immune system ; Leukocytes - metabolism ; Lymphocytes ; Macular degeneration ; Macular Degeneration - diagnosis ; Macular Degeneration - etiology ; Macular Degeneration - metabolism ; Male ; Medical imaging ; Medical sciences ; Middle Aged ; Miscellaneous ; Older people ; Ophthalmology ; Pathogenesis ; Receptors, Complement 3b - metabolism ; Receptors, Complement 3d - metabolism ; Retinopathies ; Standard deviation ; Tomography, Optical Coherence</subject><ispartof>American journal of ophthalmology, 2011-09, Vol.152 (3), p.396-399.e1</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-6fce4b2a0846cee66d29f1cc8efc179ecebf393458cce5f646728df602beab4e3</citedby><cites>FETCH-LOGICAL-c465t-6fce4b2a0846cee66d29f1cc8efc179ecebf393458cce5f646728df602beab4e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002939411001930$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24469431$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21669404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Haas, Paulina</creatorcontrib><creatorcontrib>Aggermann, Tina</creatorcontrib><creatorcontrib>Nagl, Manfred</creatorcontrib><creatorcontrib>Steindl-Kuscher, Kerstin</creatorcontrib><creatorcontrib>Krugluger, Walter</creatorcontrib><creatorcontrib>Binder, Susanne</creatorcontrib><title>Implication of CD21, CD35, and CD55 in the Pathogenesis of Age-Related Macular Degeneration</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>Purpose To determine a possible implication of CD21, CD35, and CD55 in the pathogenesis of age-related macular degeneration (AMD) by assessing the difference in expression rates of these factors on AMD patients and a control group. Design Case-control study. Methods Fifty unrelated AMD patients and 48 unrelated sex- and age-matched control subjects participated in this case-control study. Samples of fresh EDTA-blood were stained and flow cytometry was chosen to measure fluorescence emissions. The association between exudative AMD and CD21, CD35, and CD55 was evaluated from all patients who completed the study. Results Our study shows CD35 to be expressed in a significantly higher frequency in AMD patients on monocytes ( P = .00586), lymphocytes ( P = .000605), and granulocytes ( P < .000033). In contrast, the expression rate of CD21 ( P > .05) and CD55 ( P > .05) are similar in both groups. Conclusion More regulative factors of the complement system are involved in pathogenesis of AMD. Our study underlines the key role of the complement system in AMD and shows the involvement of the whole immune system through more regulative factors.</description><subject>Aged</subject><subject>Arthritis</subject><subject>Autoimmune diseases</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>CD55 Antigens - metabolism</subject><subject>Diabetic retinopathy</subject><subject>Disease</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Flow Cytometry</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Immune system</subject><subject>Leukocytes - metabolism</subject><subject>Lymphocytes</subject><subject>Macular degeneration</subject><subject>Macular Degeneration - diagnosis</subject><subject>Macular Degeneration - etiology</subject><subject>Macular Degeneration - metabolism</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Older people</subject><subject>Ophthalmology</subject><subject>Pathogenesis</subject><subject>Receptors, Complement 3b - metabolism</subject><subject>Receptors, Complement 3d - metabolism</subject><subject>Retinopathies</subject><subject>Standard deviation</subject><subject>Tomography, Optical Coherence</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kl2L1DAUhoMo7rj6A7yRgog325qTpGnLgrDM-rGwovhx5UVIT092M3baMWmF_femzujCXniTD3jew8mTw9hT4AVw0K82hd2MheAABRcFh-oeW0FdNTnUDdxnK865yBvZqCP2KMZNuupKVQ_ZkQCtG8XVin2_2O56j3by45CNLlufCzhJqyxPMjt06VSWmR-y6ZqyT3a6Hq9ooOjjwp5dUf6ZejtRl32wOPc2ZOe0AOFPvcfsgbN9pCeH_Zh9e_vm6_p9fvnx3cX67DJHpcsp1w5JtcLyWmkk0roTjQPEmhxC1RBS62QjVVkjUum00pWoO6e5aMm2iuQxe7mvuwvjz5niZLY-IvW9HWico6lrVatSg0zk8zvkZpzDkJozwKUuEynLRMGewjDGGMiZXfBbG24SZBbxZmOSeLOIN1yYJD5lnh0qz-2Wun-Jv6YT8OIA2Ii2d8EO6OMtp1TiJCTudM9RMvbLUzARPQ1InQ-Ek-lG_982Xt9JY--H9L_9D7qhePtaE1PAfFkmZBkQAM6hkVz-Bm0Bsjg</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Haas, Paulina</creator><creator>Aggermann, Tina</creator><creator>Nagl, Manfred</creator><creator>Steindl-Kuscher, Kerstin</creator><creator>Krugluger, Walter</creator><creator>Binder, Susanne</creator><general>Elsevier Inc</general><general>Elsevier</general><general>Elsevier Limited</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Implication of CD21, CD35, and CD55 in the Pathogenesis of Age-Related Macular Degeneration</title><author>Haas, Paulina ; Aggermann, Tina ; Nagl, Manfred ; Steindl-Kuscher, Kerstin ; Krugluger, Walter ; Binder, Susanne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-6fce4b2a0846cee66d29f1cc8efc179ecebf393458cce5f646728df602beab4e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Arthritis</topic><topic>Autoimmune diseases</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>CD55 Antigens - metabolism</topic><topic>Diabetic retinopathy</topic><topic>Disease</topic><topic>Erythrocytes - metabolism</topic><topic>Female</topic><topic>Flow Cytometry</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Immune system</topic><topic>Leukocytes - metabolism</topic><topic>Lymphocytes</topic><topic>Macular degeneration</topic><topic>Macular Degeneration - diagnosis</topic><topic>Macular Degeneration - etiology</topic><topic>Macular Degeneration - metabolism</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Older people</topic><topic>Ophthalmology</topic><topic>Pathogenesis</topic><topic>Receptors, Complement 3b - metabolism</topic><topic>Receptors, Complement 3d - metabolism</topic><topic>Retinopathies</topic><topic>Standard deviation</topic><topic>Tomography, Optical Coherence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haas, Paulina</creatorcontrib><creatorcontrib>Aggermann, Tina</creatorcontrib><creatorcontrib>Nagl, Manfred</creatorcontrib><creatorcontrib>Steindl-Kuscher, Kerstin</creatorcontrib><creatorcontrib>Krugluger, Walter</creatorcontrib><creatorcontrib>Binder, Susanne</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Haas, Paulina</au><au>Aggermann, Tina</au><au>Nagl, Manfred</au><au>Steindl-Kuscher, Kerstin</au><au>Krugluger, Walter</au><au>Binder, Susanne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Implication of CD21, CD35, and CD55 in the Pathogenesis of Age-Related Macular Degeneration</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>152</volume><issue>3</issue><spage>396</spage><epage>399.e1</epage><pages>396-399.e1</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><coden>AJOPAA</coden><abstract>Purpose To determine a possible implication of CD21, CD35, and CD55 in the pathogenesis of age-related macular degeneration (AMD) by assessing the difference in expression rates of these factors on AMD patients and a control group. Design Case-control study. Methods Fifty unrelated AMD patients and 48 unrelated sex- and age-matched control subjects participated in this case-control study. Samples of fresh EDTA-blood were stained and flow cytometry was chosen to measure fluorescence emissions. The association between exudative AMD and CD21, CD35, and CD55 was evaluated from all patients who completed the study. Results Our study shows CD35 to be expressed in a significantly higher frequency in AMD patients on monocytes ( P = .00586), lymphocytes ( P = .000605), and granulocytes ( P < .000033). In contrast, the expression rate of CD21 ( P > .05) and CD55 ( P > .05) are similar in both groups. Conclusion More regulative factors of the complement system are involved in pathogenesis of AMD. Our study underlines the key role of the complement system in AMD and shows the involvement of the whole immune system through more regulative factors.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21669404</pmid><doi>10.1016/j.ajo.2011.02.017</doi><tpages>4</tpages></addata></record> |
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| subjects | Aged Arthritis Autoimmune diseases Biological and medical sciences Case-Control Studies CD55 Antigens - metabolism Diabetic retinopathy Disease Erythrocytes - metabolism Female Flow Cytometry Fluorescein Angiography Humans Immune system Leukocytes - metabolism Lymphocytes Macular degeneration Macular Degeneration - diagnosis Macular Degeneration - etiology Macular Degeneration - metabolism Male Medical imaging Medical sciences Middle Aged Miscellaneous Older people Ophthalmology Pathogenesis Receptors, Complement 3b - metabolism Receptors, Complement 3d - metabolism Retinopathies Standard deviation Tomography, Optical Coherence |
| title | Implication of CD21, CD35, and CD55 in the Pathogenesis of Age-Related Macular Degeneration |
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