Glutamine and α‐ketoglutarate as glutamate sources for glutathione synthesis in human erythrocytes

Glutathione (GSH) is an intracellular antioxidant synthesized from glutamate, cysteine and glycine. The human erythrocyte (red blood cell, RBC) requires a continuous supply of glutamate to prevent the limitation of GSH synthesis in the presence of sufficient cysteine, but the RBC membrane is almost...

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Veröffentlicht in:	The FEBS journal 2011-09, Vol.278 (17), p.3152-3163
Hauptverfasser:	Whillier, Stephney, Garcia, Barbara, Chapman, Bogdan E., Kuchel, Philip W., Raftos, Julia E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - metabolism Alanine Transaminase - metabolism erythrocyte Erythrocytes - enzymology Erythrocytes - metabolism glutamate Glutaminase - metabolism glutamine Glutamine - metabolism glutathione Glutathione - metabolism Humans Ketoglutaric Acids - metabolism Kinetics Magnetic Resonance Spectroscopy Models, Biological α‐ketoglutarate
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