BMP-2 suppresses renal interstitial fibrosis by regulating epithelial-mesenchymal transition

Dysregulation of epithelial‐to‐mesenchymal transition (EMT) may contribute to renal fibrogenesis. Our previous study indicated that bone morphogenetic protein‐2 (BMP‐2) significantly reversed transforming growth factor (TGF)‐β1‐induced renal interstitial fibrosis. In this study, we examined the unde...

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Veröffentlicht in:	Journal of cellular biochemistry 2011-09, Vol.112 (9), p.2558-2565
Hauptverfasser:	Yang, Yu-Lin, Ju, Hong-Zen, Liu, Shu-Fen, Lee, Tao-Chen, Shih, Yuan-Wei, Chuang, Lea-Yea, Guh, Jinn-Yuh, Yang, Ya-Ying, Liao, Tung-Nan, Hung, Tsung-Jen, Hung, Min-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Antigens, Differentiation - metabolism BMP-2 Bone Morphogenetic Protein 2 - pharmacology Bone Morphogenetic Protein 2 - physiology Cadherins - metabolism Cell Line Cell Movement EMT Epithelial-Mesenchymal Transition Fibroblasts - metabolism Fibroblasts - pathology Fibronectins - metabolism Fibrosis Kidney - metabolism Kidney - pathology Rats RNA Interference Snail Snail Family Transcription Factors TGF-β1 Transcription Factors - genetics Transcription Factors - metabolism Transforming Growth Factor beta1 - pharmacology Transforming Growth Factor beta1 - physiology
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