Proteasomal Inhibition Promotes ATP-Binding Cassette Transporter A1 (ABCA1) and ABCG1 Expression and Cholesterol Efflux From Macrophages In Vitro and In Vivo

OBJECTIVE—ATP-binding cassette transporter A1 (ABCA1) and ABCG1 are key molecules in an initial step of reverse cholesterol transport (RCT), a major antiatherogenic property of high-density lipoprotein (HDL). The ubiquitin-proteasome system (UPS) mediates nonlysosomal pathways for protein degradatio...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-09, Vol.31 (9), p.1980-1987
Hauptverfasser:	Ogura, Masatsune, Ayaori, Makoto, Terao, Yoshio, Hisada, Tetsuya, Iizuka, Maki, Takiguchi, Shunichi, Uto-Kondo, Harumi, Yakushiji, Emi, Nakaya, Kazuhiro, Sasaki, Makoto, Komatsu, Tomohiro, Ozasa, Hideki, Ohsuzu, Fumitaka, Ikewaki, Katsunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoprotein A-I - physiology Associated diseases and complications Atherosclerosis (general aspects, experimental research) ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Sub-Family G, Member 1 ATP-Binding Cassette Transporters - analysis ATP-Binding Cassette Transporters - physiology Biological and medical sciences Blood and lymphatic vessels Boronic Acids - pharmacology Bortezomib Cardiology. Vascular system Cells, Cultured Cholesterol - metabolism Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Hep G2 Cells Humans Lipoproteins - analysis Lipoproteins - physiology Lipoproteins, HDL - physiology Macrophages - metabolism Medical sciences Mice Phosphorylation Proteasome Endopeptidase Complex - physiology Proteasome Inhibitors Pyrazines - pharmacology Ubiquitin-Protein Ligases - physiology Ubiquitination
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