Leukocyte Telomere Length Is Associated With High-Risk Plaques on Virtual Histology Intravascular Ultrasound and Increased Proinflammatory Activity

OBJECTIVE—Leukocyte telomere length (LTL), a marker of cellular senescence, is inversely associated with cardiovascular events. However, whether LTL reflects plaque extent or unstable plaques, and the mechanisms underlying any association are unknown. METHODS AND RESULTS—One hundred seventy patients...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-09, Vol.31 (9), p.2157-2164
Hauptverfasser:	Calvert, Patrick A, Liew, Tze-Vun, Gorenne, Isabelle, Clarke, Murray, Costopoulos, Charis, Obaid, Daniel R, OʼSullivan, Michael, Shapiro, Leonard M, McNab, Duncan C, Densem, Cameron G, Schofield, Peter M, Braganza, Denise, Clarke, Sarah C, Ray, Kausik K, West, Nick E.J, Bennett, Martin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cellular Senescence Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - etiology Coronary Artery Disease - immunology Coronary heart disease Cytokines - secretion Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Heart Humans Inflammation - etiology Leukocytes - metabolism Lymphocytes - immunology Medical sciences Plaque, Atherosclerotic - diagnostic imaging Plaque, Atherosclerotic - etiology Plaque, Atherosclerotic - immunology Risk Risk Factors Telomere Ultrasonography, Interventional
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