Differential LEF1 and TCF4 expression is involved in melanoma cell phenotype switching

Summary Recent observations suggest that melanoma cells drive disease progression by switching back and forth between phenotypic states of proliferation and invasion. Phenotype switching has been linked to changes in Wnt signalling, and we therefore looked for cell phenotype‐specific differences in...

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Veröffentlicht in:	Pigment cell and melanoma research 2011-08, Vol.24 (4), p.631-642
Hauptverfasser:	Eichhoff, Ossia M., Weeraratna, Ashani, Zipser, Marie C., Denat, Laurence, Widmer, Daniel S., Xu, Mai, Kriegl, Lydia, Kirchner, Thomas, Larue, Lionel, Dummer, Reinhard, Hoek, Keith S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism beta Catenin - metabolism Cell Proliferation - drug effects Gene Expression Regulation, Neoplastic - drug effects Gene Silencing - drug effects Humans LEF1 Lymphoid Enhancer-Binding Factor 1 - genetics Lymphoid Enhancer-Binding Factor 1 - metabolism melanoma Melanoma - genetics Melanoma - pathology MITF Models, Biological Neoplasm Invasiveness Phenotype Skin Neoplasms - genetics Skin Neoplasms - pathology TCF4 Transcription Factor 4 Transcription Factors - genetics Transcription Factors - metabolism Wnt Proteins - pharmacology WNT5A
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