RNA helicase retinoic acid-inducible gene I as a sensor of Hantaan virus replication

Hantaan virus (HTNV) causes severe human disease. The HTNV genome consists of three ssRNA segments of negative polarity that are complexed with viral nucleocapsid (N) protein. How the human innate immune system detects HTNV is unclear. RNA helicase retinoic acid-inducible gene I (RIG-I) does not sen...

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Veröffentlicht in:	Journal of general virology 2011-09, Vol.92 (Pt 9), p.2191-2200
Hauptverfasser:	Lee, Min-Hi, Lalwani, Pritesh, Raftery, Martin J, Matthaei, Markus, Lütteke, Nina, Kirsanovs, Sina, Binder, Marco, Ulrich, Rainer G, Giese, Thomas, Wolff, Thorsten, Krüger, Detlev H, Schönrich, Günther
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Line DEAD Box Protein 58 DEAD-box RNA Helicases - immunology DEAD-box RNA Helicases - metabolism epithelial cells Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques genes Hantaan virus Hantaan virus - immunology Hantaan virus - physiology Host-Pathogen Interactions human diseases Humans innate immunity Microbiology Miscellaneous nucleocapsid open reading frames Receptors, Immunologic RNA RNA helicases transfection Vaccinia virus viral load virion Virology Virus Replication viruses
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