The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer
Aim It has been suggested that colorectal neoplasms with or without microsatellite instability (MSI) can stimulate angiogenesis in different ways. The vascular endothelial growth factor (VEGF) system is essential for the angiogenetic process and the growth of malignant tumours. The aim of this stud...
Gespeichert in:
| Veröffentlicht in: | Colorectal disease 2011-09, Vol.13 (9), p.984-988 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 988 |
|---|---|
| container_issue | 9 |
| container_start_page | 984 |
| container_title | Colorectal disease |
| container_volume | 13 |
| creator | Hansen, T. F. Jensen, L. H. Spindler, K.-L. G. Lindebjerg, J. Brandslund, I. Jakobsen, A. |
| description | Aim It has been suggested that colorectal neoplasms with or without microsatellite instability (MSI) can stimulate angiogenesis in different ways. The vascular endothelial growth factor (VEGF) system is essential for the angiogenetic process and the growth of malignant tumours. The aim of this study was to analyse the relationship between serum VEGF‐A and the MSI status of patients with colorectal cancer (CRC).
Method In the study, 249 patients with CRC were divided into a test cohort of 83 patients and a validation cohort of 166. MSI was determined using immunohistochemistry. Tumours lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as high MSI. The rest were considered to be microsatellite stable (MSS). The serum VEGF‐A analyses were performed by ELISA.
Results The tumours of 15 patients in the test cohort and 27 in the validation cohort were classified as MSI. In the test cohort, patients with an MSI tumour had a significantly higher median serum VEGF‐A concentration [617 pg/ml (95% CI 445–863)], compared with patients with an MSS tumour, [317 pg/ml (95% CI 224–386)], P = 0.01. A similar relationship was confirmed in the validation cohort, P = 0.04.
Conclusion This study provides some evidence to suggest that patients with an MSI tumour have higher serum VEGF‐A levels than patients with an MSS tumour. If further validated, these findings could be of importance when considering the effects of anti‐VEGF‐A treatment. |
| doi_str_mv | 10.1111/j.1463-1318.2010.02357.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_884423875</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>884423875</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3587-420572638d7ffec1d1b81941787c11f6e23d609b631e37febc2425efcbfc53863</originalsourceid><addsrcrecordid>eNo9UU1vEzEQtRAV_YC_gHzjtMEfu2vnglQCpJUKRVVRpV4sr3eWOHjXwfaS5N_jbdrMZZ5m3jyN3kMIUzKjuT6uZ7SseUE5lTNG8pQwXonZ7hU6Oy5eP2FWyDklp-g8xjUhtBZUvkGnjFTzkhFyhrb3K8ABnE7WD3FlN7iBtAUYcIQw9vifjmZ0OmAYWp9W4Kx2-Hfw27TCnTbJB3yJ9dDi3prgo07gnE2A7RCTbmzG-4yx8c4HMCkfGz0YCG_RSaddhHfP_QL9-vb1fnFV3NwurxeXN4XhlRRFfrISrOayFV0Hhra0kXReUiGFobSrgfG2JvOm5hS46KAxrGQVdKbpTMVlzS_Qh4PuJvi_I8SkehtNflIP4MeopCxLxqWoMvP9M3NsemjVJtheh7168SoTPh0IW-tgf9xToqZM1FpN1qvJejVlop4yUTu1uP1yPcEsUBwEbEywOwro8EfVgotKPfxYqmr5c_H57vFOfef_AYegkRI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>884423875</pqid></control><display><type>article</type><title>The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><creator>Hansen, T. F. ; Jensen, L. H. ; Spindler, K.-L. G. ; Lindebjerg, J. ; Brandslund, I. ; Jakobsen, A.</creator><creatorcontrib>Hansen, T. F. ; Jensen, L. H. ; Spindler, K.-L. G. ; Lindebjerg, J. ; Brandslund, I. ; Jakobsen, A.</creatorcontrib><description>Aim It has been suggested that colorectal neoplasms with or without microsatellite instability (MSI) can stimulate angiogenesis in different ways. The vascular endothelial growth factor (VEGF) system is essential for the angiogenetic process and the growth of malignant tumours. The aim of this study was to analyse the relationship between serum VEGF‐A and the MSI status of patients with colorectal cancer (CRC).
Method In the study, 249 patients with CRC were divided into a test cohort of 83 patients and a validation cohort of 166. MSI was determined using immunohistochemistry. Tumours lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as high MSI. The rest were considered to be microsatellite stable (MSS). The serum VEGF‐A analyses were performed by ELISA.
Results The tumours of 15 patients in the test cohort and 27 in the validation cohort were classified as MSI. In the test cohort, patients with an MSI tumour had a significantly higher median serum VEGF‐A concentration [617 pg/ml (95% CI 445–863)], compared with patients with an MSS tumour, [317 pg/ml (95% CI 224–386)], P = 0.01. A similar relationship was confirmed in the validation cohort, P = 0.04.
Conclusion This study provides some evidence to suggest that patients with an MSI tumour have higher serum VEGF‐A levels than patients with an MSS tumour. If further validated, these findings could be of importance when considering the effects of anti‐VEGF‐A treatment.</description><identifier>ISSN: 1462-8910</identifier><identifier>EISSN: 1463-1318</identifier><identifier>DOI: 10.1111/j.1463-1318.2010.02357.x</identifier><identifier>PMID: 20594200</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Adenocarcinoma - blood ; Adenocarcinoma - genetics ; Adenocarcinoma - pathology ; Adenosine Triphosphatases - genetics ; Adult ; Aged ; Aged, 80 and over ; Colorectal neoplasms ; Colorectal Neoplasms - blood ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; DNA Repair Enzymes - genetics ; DNA-Binding Proteins - genetics ; Female ; Humans ; Male ; Microsatellite Instability ; Middle Aged ; Mismatch Repair Endonuclease PMS2 ; MutL Protein Homolog 1 ; MutS Homolog 2 Protein - genetics ; Nuclear Proteins - genetics ; vascular endothelial growth factor A ; Vascular Endothelial Growth Factor A - blood</subject><ispartof>Colorectal disease, 2011-09, Vol.13 (9), p.984-988</ispartof><rights>2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland</rights><rights>2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3587-420572638d7ffec1d1b81941787c11f6e23d609b631e37febc2425efcbfc53863</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1463-1318.2010.02357.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1463-1318.2010.02357.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20594200$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hansen, T. F.</creatorcontrib><creatorcontrib>Jensen, L. H.</creatorcontrib><creatorcontrib>Spindler, K.-L. G.</creatorcontrib><creatorcontrib>Lindebjerg, J.</creatorcontrib><creatorcontrib>Brandslund, I.</creatorcontrib><creatorcontrib>Jakobsen, A.</creatorcontrib><title>The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer</title><title>Colorectal disease</title><addtitle>Colorectal Dis</addtitle><description>Aim It has been suggested that colorectal neoplasms with or without microsatellite instability (MSI) can stimulate angiogenesis in different ways. The vascular endothelial growth factor (VEGF) system is essential for the angiogenetic process and the growth of malignant tumours. The aim of this study was to analyse the relationship between serum VEGF‐A and the MSI status of patients with colorectal cancer (CRC).
Method In the study, 249 patients with CRC were divided into a test cohort of 83 patients and a validation cohort of 166. MSI was determined using immunohistochemistry. Tumours lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as high MSI. The rest were considered to be microsatellite stable (MSS). The serum VEGF‐A analyses were performed by ELISA.
Results The tumours of 15 patients in the test cohort and 27 in the validation cohort were classified as MSI. In the test cohort, patients with an MSI tumour had a significantly higher median serum VEGF‐A concentration [617 pg/ml (95% CI 445–863)], compared with patients with an MSS tumour, [317 pg/ml (95% CI 224–386)], P = 0.01. A similar relationship was confirmed in the validation cohort, P = 0.04.
Conclusion This study provides some evidence to suggest that patients with an MSI tumour have higher serum VEGF‐A levels than patients with an MSS tumour. If further validated, these findings could be of importance when considering the effects of anti‐VEGF‐A treatment.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adenocarcinoma - blood</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenosine Triphosphatases - genetics</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Colorectal neoplasms</subject><subject>Colorectal Neoplasms - blood</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>DNA Repair Enzymes - genetics</subject><subject>DNA-Binding Proteins - genetics</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Microsatellite Instability</subject><subject>Middle Aged</subject><subject>Mismatch Repair Endonuclease PMS2</subject><subject>MutL Protein Homolog 1</subject><subject>MutS Homolog 2 Protein - genetics</subject><subject>Nuclear Proteins - genetics</subject><subject>vascular endothelial growth factor A</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><issn>1462-8910</issn><issn>1463-1318</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9UU1vEzEQtRAV_YC_gHzjtMEfu2vnglQCpJUKRVVRpV4sr3eWOHjXwfaS5N_jbdrMZZ5m3jyN3kMIUzKjuT6uZ7SseUE5lTNG8pQwXonZ7hU6Oy5eP2FWyDklp-g8xjUhtBZUvkGnjFTzkhFyhrb3K8ABnE7WD3FlN7iBtAUYcIQw9vifjmZ0OmAYWp9W4Kx2-Hfw27TCnTbJB3yJ9dDi3prgo07gnE2A7RCTbmzG-4yx8c4HMCkfGz0YCG_RSaddhHfP_QL9-vb1fnFV3NwurxeXN4XhlRRFfrISrOayFV0Hhra0kXReUiGFobSrgfG2JvOm5hS46KAxrGQVdKbpTMVlzS_Qh4PuJvi_I8SkehtNflIP4MeopCxLxqWoMvP9M3NsemjVJtheh7168SoTPh0IW-tgf9xToqZM1FpN1qvJejVlop4yUTu1uP1yPcEsUBwEbEywOwro8EfVgotKPfxYqmr5c_H57vFOfef_AYegkRI</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Hansen, T. F.</creator><creator>Jensen, L. H.</creator><creator>Spindler, K.-L. G.</creator><creator>Lindebjerg, J.</creator><creator>Brandslund, I.</creator><creator>Jakobsen, A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer</title><author>Hansen, T. F. ; Jensen, L. H. ; Spindler, K.-L. G. ; Lindebjerg, J. ; Brandslund, I. ; Jakobsen, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3587-420572638d7ffec1d1b81941787c11f6e23d609b631e37febc2425efcbfc53863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Adenocarcinoma - blood</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenosine Triphosphatases - genetics</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Colorectal neoplasms</topic><topic>Colorectal Neoplasms - blood</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>DNA Repair Enzymes - genetics</topic><topic>DNA-Binding Proteins - genetics</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Microsatellite Instability</topic><topic>Middle Aged</topic><topic>Mismatch Repair Endonuclease PMS2</topic><topic>MutL Protein Homolog 1</topic><topic>MutS Homolog 2 Protein - genetics</topic><topic>Nuclear Proteins - genetics</topic><topic>vascular endothelial growth factor A</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hansen, T. F.</creatorcontrib><creatorcontrib>Jensen, L. H.</creatorcontrib><creatorcontrib>Spindler, K.-L. G.</creatorcontrib><creatorcontrib>Lindebjerg, J.</creatorcontrib><creatorcontrib>Brandslund, I.</creatorcontrib><creatorcontrib>Jakobsen, A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hansen, T. F.</au><au>Jensen, L. H.</au><au>Spindler, K.-L. G.</au><au>Lindebjerg, J.</au><au>Brandslund, I.</au><au>Jakobsen, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer</atitle><jtitle>Colorectal disease</jtitle><addtitle>Colorectal Dis</addtitle><date>2011-09</date><risdate>2011</risdate><volume>13</volume><issue>9</issue><spage>984</spage><epage>988</epage><pages>984-988</pages><issn>1462-8910</issn><eissn>1463-1318</eissn><abstract>Aim It has been suggested that colorectal neoplasms with or without microsatellite instability (MSI) can stimulate angiogenesis in different ways. The vascular endothelial growth factor (VEGF) system is essential for the angiogenetic process and the growth of malignant tumours. The aim of this study was to analyse the relationship between serum VEGF‐A and the MSI status of patients with colorectal cancer (CRC).
Method In the study, 249 patients with CRC were divided into a test cohort of 83 patients and a validation cohort of 166. MSI was determined using immunohistochemistry. Tumours lacking protein expression of any of the four mismatch repair genes (MLH1, PMS2, MSH2 or MSH6) were labelled as high MSI. The rest were considered to be microsatellite stable (MSS). The serum VEGF‐A analyses were performed by ELISA.
Results The tumours of 15 patients in the test cohort and 27 in the validation cohort were classified as MSI. In the test cohort, patients with an MSI tumour had a significantly higher median serum VEGF‐A concentration [617 pg/ml (95% CI 445–863)], compared with patients with an MSS tumour, [317 pg/ml (95% CI 224–386)], P = 0.01. A similar relationship was confirmed in the validation cohort, P = 0.04.
Conclusion This study provides some evidence to suggest that patients with an MSI tumour have higher serum VEGF‐A levels than patients with an MSS tumour. If further validated, these findings could be of importance when considering the effects of anti‐VEGF‐A treatment.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20594200</pmid><doi>10.1111/j.1463-1318.2010.02357.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1462-8910 |
| ispartof | Colorectal disease, 2011-09, Vol.13 (9), p.984-988 |
| issn | 1462-8910 1463-1318 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_884423875 |
| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Adaptor Proteins, Signal Transducing - genetics Adenocarcinoma - blood Adenocarcinoma - genetics Adenocarcinoma - pathology Adenosine Triphosphatases - genetics Adult Aged Aged, 80 and over Colorectal neoplasms Colorectal Neoplasms - blood Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Repair Enzymes - genetics DNA-Binding Proteins - genetics Female Humans Male Microsatellite Instability Middle Aged Mismatch Repair Endonuclease PMS2 MutL Protein Homolog 1 MutS Homolog 2 Protein - genetics Nuclear Proteins - genetics vascular endothelial growth factor A Vascular Endothelial Growth Factor A - blood |
| title | The relationship between serum vascular endothelial growth factor A and microsatellite instability in colorectal cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A18%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20relationship%20between%20serum%20vascular%20endothelial%20growth%20factor%20A%20and%20microsatellite%20instability%20in%20colorectal%20cancer&rft.jtitle=Colorectal%20disease&rft.au=Hansen,%20T.%20F.&rft.date=2011-09&rft.volume=13&rft.issue=9&rft.spage=984&rft.epage=988&rft.pages=984-988&rft.issn=1462-8910&rft.eissn=1463-1318&rft_id=info:doi/10.1111/j.1463-1318.2010.02357.x&rft_dat=%3Cproquest_pubme%3E884423875%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=884423875&rft_id=info:pmid/20594200&rfr_iscdi=true |