CXCR4 Overexpression Is Associated with Poor Outcome in Females Diagnosed with Stage IV Non-small Cell Lung Cancer

It has been proposed that the chemokine receptor, CXCR4, and its ligand, stromal cell-derived factor-1 (SDF-1), play a critical role in organ-specific tumor metastasis. High CXCR4 expression in resected non-small cell lung cancer (NSCLC) tumors is associated with poorer outcome; however, its effect...

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Veröffentlicht in:	Journal of thoracic oncology 2011-07, Vol.6 (7), p.1169-1178
Hauptverfasser:	Otsuka, Shannon, Klimowicz, Alexander C., Kopciuk, Karen, Petrillo, Stephanie K., Konno, Mie, Hao, Desiree, Muzik, Huong, Stolte, Erin, Boland, William, Morris, Don, Magliocco, Anthony M., Bebb, D. Gwyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Aged, 80 and over Carcinoma, Large Cell - metabolism Carcinoma, Large Cell - mortality Carcinoma, Large Cell - pathology Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cohort Studies CXCR4 Female Females Follow-Up Studies Humans Immunoenzyme Techniques Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Male Middle Aged Neoplasm Staging Non-small cell lung cancer Outcome Prognosis Receptors, CXCR4 - metabolism Retrospective Studies Sex Factors Stage IV Survival Rate Tissue Array Analysis
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