Additive Inhibitory Effects of Progesterone and Sodium Nitroprusside on Uterine Contractility During Pregnancy
Progesterone (P4) and nitric oxide (NO) suppress uterine contractility (CTX). This study compares the effects of P4 to sodium nitroprusside (SNP, an NO donor) and their combination on human CTX of term/preterm and labor/nonlabor tissues. Uterine tissues (n = 128) from women (n = 28) undergoing Cesar...
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| Veröffentlicht in: | Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2011-09, Vol.18 (9), p.868-875 |
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| creator | Orth, Teresa A. Shi, Shao-Qing Williamson, Kelli Shi, Leili Chambliss, Linda Coonrod, Dean V. Balducci, James Garfield, Robert E. |
| description | Progesterone (P4) and nitric oxide (NO) suppress uterine contractility (CTX). This study compares the effects of P4 to sodium nitroprusside (SNP, an NO donor) and their combination on human CTX of term/preterm and labor/nonlabor tissues. Uterine tissues (n = 128) from women (n = 28) undergoing Cesarean were suspended in organ baths. Tissues (n ≥ 6/group) were treated with vehicle, P4, SNP, or combinations. A subset of tissues (n ≥ 2/group) from term/preterm ± labor and nonpregnant patients was analyzed with P4 alone. Analysis of variance (ANOVA) was used for statistical differences (P < .05). The combination of P4 with SNP significantly suppresses CTX (% inhibition of −127.1 ± 14.5) to the levels lower than with either P4 (−20.1 ± 8.6) or SNP alone (−72.0 ± 11.2). Suppression of P4 is similar in term, preterm, and nonpregnant tissues, with increased sensitivity in laboring tissues. This indicates that P4 or SNP alone may be used for preterm labor and their combination may be more successful. |
| doi_str_mv | 10.1177/1933719111398141 |
| format | Article |
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This study compares the effects of P4 to sodium nitroprusside (SNP, an NO donor) and their combination on human CTX of term/preterm and labor/nonlabor tissues. Uterine tissues (n = 128) from women (n = 28) undergoing Cesarean were suspended in organ baths. Tissues (n ≥ 6/group) were treated with vehicle, P4, SNP, or combinations. A subset of tissues (n ≥ 2/group) from term/preterm ± labor and nonpregnant patients was analyzed with P4 alone. Analysis of variance (ANOVA) was used for statistical differences (P < .05). The combination of P4 with SNP significantly suppresses CTX (% inhibition of −127.1 ± 14.5) to the levels lower than with either P4 (−20.1 ± 8.6) or SNP alone (−72.0 ± 11.2). Suppression of P4 is similar in term, preterm, and nonpregnant tissues, with increased sensitivity in laboring tissues. This indicates that P4 or SNP alone may be used for preterm labor and their combination may be more successful.</description><identifier>ISSN: 1933-7191</identifier><identifier>EISSN: 1933-7205</identifier><identifier>DOI: 10.1177/1933719111398141</identifier><identifier>PMID: 21421898</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Biological and medical sciences ; Diseases of mother, fetus and pregnancy ; Dose-Response Relationship, Drug ; Drug Synergism ; Embryology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; In Vitro Techniques ; Labor, Obstetric - drug effects ; Medical sciences ; Medicine & Public Health ; Myometrium - drug effects ; Nitric Oxide Donors - pharmacology ; Nitroprusside - pharmacology ; Obstetrics/Perinatology/Midwifery ; Pregnancy ; Pregnancy. Fetus. Placenta ; Progesterone - pharmacology ; Reproductive Medicine ; Uterine Contraction - drug effects</subject><ispartof>Reproductive sciences (Thousand Oaks, Calif.), 2011-09, Vol.18 (9), p.868-875</ispartof><rights>The Author(s) 2011</rights><rights>Society for Reproductive Investigation 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-43252d1b993e50b37737c6c81ac1300a0fb4d34bbcd68e7bcc150b354b988b433</citedby><cites>FETCH-LOGICAL-c408t-43252d1b993e50b37737c6c81ac1300a0fb4d34bbcd68e7bcc150b354b988b433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1933719111398141$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1933719111398141$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21799,27903,27904,41467,42536,43600,43601,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24457837$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21421898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Orth, Teresa A.</creatorcontrib><creatorcontrib>Shi, Shao-Qing</creatorcontrib><creatorcontrib>Williamson, Kelli</creatorcontrib><creatorcontrib>Shi, Leili</creatorcontrib><creatorcontrib>Chambliss, Linda</creatorcontrib><creatorcontrib>Coonrod, Dean V.</creatorcontrib><creatorcontrib>Balducci, James</creatorcontrib><creatorcontrib>Garfield, Robert E.</creatorcontrib><title>Additive Inhibitory Effects of Progesterone and Sodium Nitroprusside on Uterine Contractility During Pregnancy</title><title>Reproductive sciences (Thousand Oaks, Calif.)</title><addtitle>Reprod. Sci</addtitle><addtitle>Reprod Sci</addtitle><description>Progesterone (P4) and nitric oxide (NO) suppress uterine contractility (CTX). This study compares the effects of P4 to sodium nitroprusside (SNP, an NO donor) and their combination on human CTX of term/preterm and labor/nonlabor tissues. Uterine tissues (n = 128) from women (n = 28) undergoing Cesarean were suspended in organ baths. Tissues (n ≥ 6/group) were treated with vehicle, P4, SNP, or combinations. A subset of tissues (n ≥ 2/group) from term/preterm ± labor and nonpregnant patients was analyzed with P4 alone. Analysis of variance (ANOVA) was used for statistical differences (P < .05). The combination of P4 with SNP significantly suppresses CTX (% inhibition of −127.1 ± 14.5) to the levels lower than with either P4 (−20.1 ± 8.6) or SNP alone (−72.0 ± 11.2). Suppression of P4 is similar in term, preterm, and nonpregnant tissues, with increased sensitivity in laboring tissues. This indicates that P4 or SNP alone may be used for preterm labor and their combination may be more successful.</description><subject>Biological and medical sciences</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Synergism</subject><subject>Embryology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Labor, Obstetric - drug effects</subject><subject>Medical sciences</subject><subject>Medicine & Public Health</subject><subject>Myometrium - drug effects</subject><subject>Nitric Oxide Donors - pharmacology</subject><subject>Nitroprusside - pharmacology</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Progesterone - pharmacology</subject><subject>Reproductive Medicine</subject><subject>Uterine Contraction - drug effects</subject><issn>1933-7191</issn><issn>1933-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM9LHDEYhkNRump776nkIj1NzTfJmOQoq62CqNB6HvJr1iyzyTbJFPa_N8uuLXgQTwlfnvcN34PQFyDfATg_A0kpBwkAVApg8AEdbUcNb0l38HKv7zN0nPOSkI7JVnxEsxZYC0KKIxQurPXF_3X4Jjx57UtMG3w1DM6UjOOAH1JcuFxcisFhFSz-Fa2fVvjOlxTXacrZW4djwI-V8ZWZx1CSMsWPvmzw5VSHi9riFkEFs_mEDgc1Zvd5f56gxx9Xv-fXze39z5v5xW1jGBGlYbTtWgtaSuo6oinnlJtzI0AZoIQoMmhmKdPa2HPhuDYGtljHtBRCM0pP0Ldd7zrFP1NdoF_5bNw4quDilHshWMsJl1BJsiNNijknN_Tr5FcqbXog_VZy_1pyjXzdl0965ey_wIvVCpzuAZWNGodUV_f5P8dYxwXllYMdl9dbTS71yzilUMW89Xmzz6iFewf_DK8poOU</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Orth, Teresa A.</creator><creator>Shi, Shao-Qing</creator><creator>Williamson, Kelli</creator><creator>Shi, Leili</creator><creator>Chambliss, Linda</creator><creator>Coonrod, Dean V.</creator><creator>Balducci, James</creator><creator>Garfield, Robert E.</creator><general>SAGE Publications</general><general>Springer International Publishing</general><general>Sage Publications</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Additive Inhibitory Effects of Progesterone and Sodium Nitroprusside on Uterine Contractility During Pregnancy</title><author>Orth, Teresa A. ; Shi, Shao-Qing ; Williamson, Kelli ; Shi, Leili ; Chambliss, Linda ; Coonrod, Dean V. ; Balducci, James ; Garfield, Robert E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-43252d1b993e50b37737c6c81ac1300a0fb4d34bbcd68e7bcc150b354b988b433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Synergism</topic><topic>Embryology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Labor, Obstetric - drug effects</topic><topic>Medical sciences</topic><topic>Medicine & Public Health</topic><topic>Myometrium - drug effects</topic><topic>Nitric Oxide Donors - pharmacology</topic><topic>Nitroprusside - pharmacology</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Progesterone - pharmacology</topic><topic>Reproductive Medicine</topic><topic>Uterine Contraction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Orth, Teresa A.</creatorcontrib><creatorcontrib>Shi, Shao-Qing</creatorcontrib><creatorcontrib>Williamson, Kelli</creatorcontrib><creatorcontrib>Shi, Leili</creatorcontrib><creatorcontrib>Chambliss, Linda</creatorcontrib><creatorcontrib>Coonrod, Dean V.</creatorcontrib><creatorcontrib>Balducci, James</creatorcontrib><creatorcontrib>Garfield, Robert E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Orth, Teresa A.</au><au>Shi, Shao-Qing</au><au>Williamson, Kelli</au><au>Shi, Leili</au><au>Chambliss, Linda</au><au>Coonrod, Dean V.</au><au>Balducci, James</au><au>Garfield, Robert E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Additive Inhibitory Effects of Progesterone and Sodium Nitroprusside on Uterine Contractility During Pregnancy</atitle><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle><stitle>Reprod. Sci</stitle><addtitle>Reprod Sci</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>18</volume><issue>9</issue><spage>868</spage><epage>875</epage><pages>868-875</pages><issn>1933-7191</issn><eissn>1933-7205</eissn><abstract>Progesterone (P4) and nitric oxide (NO) suppress uterine contractility (CTX). This study compares the effects of P4 to sodium nitroprusside (SNP, an NO donor) and their combination on human CTX of term/preterm and labor/nonlabor tissues. Uterine tissues (n = 128) from women (n = 28) undergoing Cesarean were suspended in organ baths. Tissues (n ≥ 6/group) were treated with vehicle, P4, SNP, or combinations. A subset of tissues (n ≥ 2/group) from term/preterm ± labor and nonpregnant patients was analyzed with P4 alone. Analysis of variance (ANOVA) was used for statistical differences (P < .05). The combination of P4 with SNP significantly suppresses CTX (% inhibition of −127.1 ± 14.5) to the levels lower than with either P4 (−20.1 ± 8.6) or SNP alone (−72.0 ± 11.2). Suppression of P4 is similar in term, preterm, and nonpregnant tissues, with increased sensitivity in laboring tissues. This indicates that P4 or SNP alone may be used for preterm labor and their combination may be more successful.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>21421898</pmid><doi>10.1177/1933719111398141</doi><tpages>8</tpages></addata></record> |
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| subjects | Biological and medical sciences Diseases of mother, fetus and pregnancy Dose-Response Relationship, Drug Drug Synergism Embryology Female Gynecology. Andrology. Obstetrics Humans In Vitro Techniques Labor, Obstetric - drug effects Medical sciences Medicine & Public Health Myometrium - drug effects Nitric Oxide Donors - pharmacology Nitroprusside - pharmacology Obstetrics/Perinatology/Midwifery Pregnancy Pregnancy. Fetus. Placenta Progesterone - pharmacology Reproductive Medicine Uterine Contraction - drug effects |
| title | Additive Inhibitory Effects of Progesterone and Sodium Nitroprusside on Uterine Contractility During Pregnancy |
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