Inhibition of MDM2 attenuates neointimal hyperplasia via suppression of vascular proliferation and inflammation

Tumour protein p53 plays an important role in the vascular remodelling process as well as in oncogenesis. p53 is negatively regulated by murine double minute 2 (MDM2). A recently developed MDM2 inhibitor, nutlin-3, is a non-genotoxic activator of the p53 pathway. So far, the effect of MDM2 inhibitio...

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Veröffentlicht in:	Cardiovascular research 2011-09, Vol.91 (4), p.711-719
Hauptverfasser:	HASHIMOTO, Toru, ICHIKI, Toshihiro, IKEDA, Jiro, NARABAYASHI, Eriko, MATSUURA, Hirohide, MIYAZAKI, Ryohei, INANAGA, Keita, TAKEDA, Kotaro, SUNAGAWA, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cardiology. Vascular system Cell Cycle - drug effects Cell Movement - drug effects Cell Proliferation - drug effects Hyperplasia Imidazoles - pharmacology Inflammation - prevention & control Male Medical sciences Mice Mice, Inbred C57BL Muscle, Smooth, Vascular - cytology Neointima - pathology NF-kappa B - metabolism Piperazines - pharmacology Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors Proto-Oncogene Proteins c-mdm2 - physiology Rats Rats, Sprague-Dawley Tumor Suppressor Protein p53 - physiology
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