Optimizing the therapeutic index of liposomal glucocorticoids in experimental arthritis

Small-sized (less than 150 nm) long-circulating liposomes (LCL) may be useful as drug-targeting vehicles for anti-inflammatory agents in arthritis, since they selectively home at inflamed joints after i.v. administration. Previously it was shown in experimental arthritis that encapsulation of glucoc...

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Veröffentlicht in:	International journal of pharmaceutics 2011-09, Vol.416 (2), p.471-477
Hauptverfasser:	van den Hoven, Jolanda M., Hofkens, Wouter, Wauben, Marca H.M., Wagenaar-Hilbers, Josee P.A., Beijnen, Jos H., Nuijen, Bastiaan, Metselaar, Josbert M., Storm, Gert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - toxicity Arthritis, Experimental - drug therapy Arthritis, Experimental - physiopathology Biological and medical sciences Body Weight - drug effects Budesonide - administration & dosage Budesonide - pharmacology Budesonide - toxicity Dexamethasone - administration & dosage Dexamethasone - pharmacology Dexamethasone - toxicity General pharmacology Glucocorticoids Glucocorticoids - administration & dosage Glucocorticoids - pharmacology Glucocorticoids - toxicity Hyperglycemia - chemically induced Liposomes Male Medical sciences Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Prednisolone - administration & dosage Prednisolone - pharmacology Prednisolone - toxicity Rats Rats, Inbred Lew Rheumatoid arthritis Targetting Therapeutic index
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