Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients
Kianda MN, Wissing KM, Broeders NE, Lemy A, Ghisdal L, Hoang AD, Mikhalski D, Donckier V, Vereerstraeten P, Abramowicz D. Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients. Clin Transplant 2011: 25: 576–583. © 2010 John Wiley & Sons...
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| creator | Kianda, Mireille N. Wissing, Karl M. Broeders, Nulifer E. Lemy, Anne Ghisdal, Lidia Hoang, Anh D. Mikhalski, Dimitri Donckier, Vincent Vereerstraeten, Pierre Abramowicz, Daniel |
| description | Kianda MN, Wissing KM, Broeders NE, Lemy A, Ghisdal L, Hoang AD, Mikhalski D, Donckier V, Vereerstraeten P, Abramowicz D. Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients.
Clin Transplant 2011: 25: 576–583. © 2010 John Wiley & Sons A/S.
: Little is known about the proportion of renal transplant candidates who are considered ineligible by the transplant center, the reasons of their ineligibility and their survival during dialysis. In this retrospective, single‐center study of 445 adult patients referred between 2001 and 2006, 36 (8%) were deemed ineligible for medical contraindications. The leading reason was cardiovascular (CV) (75%), specifically aorto‐iliac, and/or limb vessels atheromatosis or calcifications; ischemic heart disease; or a combination thereof. Nine patients had other contraindications that were absolute for three of them; six patients displayed a combination of relative contraindications. When compared to eligible patients (N = 409), those ineligible were significantly older (60 yr vs. 48), more often diabetics (50% vs. 15%), obese (39% vs. 17%) suffering from coronary artery disease (53% vs. 11%) and peripheral arterial disease (86% vs. 11%). Their primary nephropathy was more often diabetic and/or hypertensive/nephroangiosclerosis (61% vs. 23%), and their median dialysis vintage prior to evaluation was longer (29 months vs. 10, p |
| doi_str_mv | 10.1111/j.1399-0012.2010.01317.x |
| format | Article |
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Clin Transplant 2011: 25: 576–583. © 2010 John Wiley & Sons A/S.
: Little is known about the proportion of renal transplant candidates who are considered ineligible by the transplant center, the reasons of their ineligibility and their survival during dialysis. In this retrospective, single‐center study of 445 adult patients referred between 2001 and 2006, 36 (8%) were deemed ineligible for medical contraindications. The leading reason was cardiovascular (CV) (75%), specifically aorto‐iliac, and/or limb vessels atheromatosis or calcifications; ischemic heart disease; or a combination thereof. Nine patients had other contraindications that were absolute for three of them; six patients displayed a combination of relative contraindications. When compared to eligible patients (N = 409), those ineligible were significantly older (60 yr vs. 48), more often diabetics (50% vs. 15%), obese (39% vs. 17%) suffering from coronary artery disease (53% vs. 11%) and peripheral arterial disease (86% vs. 11%). Their primary nephropathy was more often diabetic and/or hypertensive/nephroangiosclerosis (61% vs. 23%), and their median dialysis vintage prior to evaluation was longer (29 months vs. 10, p < 0.0001). The actuarial survival of ineligible patients was significantly lower than that of eligible patients (at five yr: 53% vs. 88%). Adequate control of CV risk factors before dialysis and early referral for transplantation might help to improve eligibility of renal transplant candidates.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/j.1399-0012.2010.01317.x</identifier><identifier>PMID: 20718825</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Belgium - epidemiology ; Biological and medical sciences ; Cohort Studies ; Epidemiology ; Female ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; General aspects ; Humans ; ineligibility ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - surgery ; Kidney Transplantation ; Male ; Medical sciences ; Middle Aged ; Patient Selection ; Prevalence ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; renal transplantation ; Retrospective Studies ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the urinary system ; survival ; Survival Rate ; Tissue, organ and graft immunology ; transplant evaluation ; Treatment Outcome ; wait listing</subject><ispartof>Clinical transplantation, 2011-07, Vol.25 (4), p.576-583</ispartof><rights>2010 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2010 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4367-6b3e599f87679e88eecaf7160e3a22f7e8f2573dc56d6b8846230553d609eac13</citedby><cites>FETCH-LOGICAL-c4367-6b3e599f87679e88eecaf7160e3a22f7e8f2573dc56d6b8846230553d609eac13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-0012.2010.01317.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-0012.2010.01317.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24401176$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20718825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kianda, Mireille N.</creatorcontrib><creatorcontrib>Wissing, Karl M.</creatorcontrib><creatorcontrib>Broeders, Nulifer E.</creatorcontrib><creatorcontrib>Lemy, Anne</creatorcontrib><creatorcontrib>Ghisdal, Lidia</creatorcontrib><creatorcontrib>Hoang, Anh D.</creatorcontrib><creatorcontrib>Mikhalski, Dimitri</creatorcontrib><creatorcontrib>Donckier, Vincent</creatorcontrib><creatorcontrib>Vereerstraeten, Pierre</creatorcontrib><creatorcontrib>Abramowicz, Daniel</creatorcontrib><title>Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>Kianda MN, Wissing KM, Broeders NE, Lemy A, Ghisdal L, Hoang AD, Mikhalski D, Donckier V, Vereerstraeten P, Abramowicz D. Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients.
Clin Transplant 2011: 25: 576–583. © 2010 John Wiley & Sons A/S.
: Little is known about the proportion of renal transplant candidates who are considered ineligible by the transplant center, the reasons of their ineligibility and their survival during dialysis. In this retrospective, single‐center study of 445 adult patients referred between 2001 and 2006, 36 (8%) were deemed ineligible for medical contraindications. The leading reason was cardiovascular (CV) (75%), specifically aorto‐iliac, and/or limb vessels atheromatosis or calcifications; ischemic heart disease; or a combination thereof. Nine patients had other contraindications that were absolute for three of them; six patients displayed a combination of relative contraindications. When compared to eligible patients (N = 409), those ineligible were significantly older (60 yr vs. 48), more often diabetics (50% vs. 15%), obese (39% vs. 17%) suffering from coronary artery disease (53% vs. 11%) and peripheral arterial disease (86% vs. 11%). Their primary nephropathy was more often diabetic and/or hypertensive/nephroangiosclerosis (61% vs. 23%), and their median dialysis vintage prior to evaluation was longer (29 months vs. 10, p < 0.0001). The actuarial survival of ineligible patients was significantly lower than that of eligible patients (at five yr: 53% vs. 88%). Adequate control of CV risk factors before dialysis and early referral for transplantation might help to improve eligibility of renal transplant candidates.</description><subject>Adult</subject><subject>Belgium - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>General aspects</subject><subject>Humans</subject><subject>ineligibility</subject><subject>Kidney Failure, Chronic - epidemiology</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Patient Selection</subject><subject>Prevalence</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>renal transplantation</subject><subject>Retrospective Studies</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the urinary system</subject><subject>survival</subject><subject>Survival Rate</subject><subject>Tissue, organ and graft immunology</subject><subject>transplant evaluation</subject><subject>Treatment Outcome</subject><subject>wait listing</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtvEzEURi0EomnhLyBvEJtO8GP8GCQWVUQfqCpSVcTScjx3wGHimdozIfn3eEhIt_XGV9fnu7YPQpiSOc3r42pOeVUVhFA2ZyR3CeVUzbcv0Ox48BLNSEVYriU_QacprXJXUileoxNGFNWaiRnqbwK0_qdf-tYPO9x0EUcItsVDtCH1rQ2DHXwXPuE-wsa2EBycY2fHBAnbUOM0xo3PB9gHbLHrQgI3Dn4Duf7VxQF3DS5Lgfs8BsKQ3qBXjW0TvD3sZ-j75ZeHxXVx--3qZnFxW7iSS1XIJQdRVY1WUlWgNYCzjaKSALeMNQp0w4TitROylkutS8k4EYLXklRgHeVn6MN-bh-7xxHSYNY-OWjzj6Abk8kRynhJq0zqPelil1KExvTRr23cGUrMpNuszGTVTFbNpNv80222OfrucMm4XEN9DP73m4H3B8AmZ9smS3U-PXFlSShVMnOf99wf38Lu2Q8wi4f7qcr5Yp_3aYDtMW_jbyMVV8L8uLsy8los7r9qYe74X4C_qo8</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Kianda, Mireille N.</creator><creator>Wissing, Karl M.</creator><creator>Broeders, Nulifer E.</creator><creator>Lemy, Anne</creator><creator>Ghisdal, Lidia</creator><creator>Hoang, Anh D.</creator><creator>Mikhalski, Dimitri</creator><creator>Donckier, Vincent</creator><creator>Vereerstraeten, Pierre</creator><creator>Abramowicz, Daniel</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201107</creationdate><title>Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients</title><author>Kianda, Mireille N. ; Wissing, Karl M. ; Broeders, Nulifer E. ; Lemy, Anne ; Ghisdal, Lidia ; Hoang, Anh D. ; Mikhalski, Dimitri ; Donckier, Vincent ; Vereerstraeten, Pierre ; Abramowicz, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4367-6b3e599f87679e88eecaf7160e3a22f7e8f2573dc56d6b8846230553d609eac13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Belgium - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>General aspects</topic><topic>Humans</topic><topic>ineligibility</topic><topic>Kidney Failure, Chronic - epidemiology</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - surgery</topic><topic>Kidney Transplantation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Patient Selection</topic><topic>Prevalence</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>renal transplantation</topic><topic>Retrospective Studies</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the urinary system</topic><topic>survival</topic><topic>Survival Rate</topic><topic>Tissue, organ and graft immunology</topic><topic>transplant evaluation</topic><topic>Treatment Outcome</topic><topic>wait listing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kianda, Mireille N.</creatorcontrib><creatorcontrib>Wissing, Karl M.</creatorcontrib><creatorcontrib>Broeders, Nulifer E.</creatorcontrib><creatorcontrib>Lemy, Anne</creatorcontrib><creatorcontrib>Ghisdal, Lidia</creatorcontrib><creatorcontrib>Hoang, Anh D.</creatorcontrib><creatorcontrib>Mikhalski, Dimitri</creatorcontrib><creatorcontrib>Donckier, Vincent</creatorcontrib><creatorcontrib>Vereerstraeten, Pierre</creatorcontrib><creatorcontrib>Abramowicz, Daniel</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kianda, Mireille N.</au><au>Wissing, Karl M.</au><au>Broeders, Nulifer E.</au><au>Lemy, Anne</au><au>Ghisdal, Lidia</au><au>Hoang, Anh D.</au><au>Mikhalski, Dimitri</au><au>Donckier, Vincent</au><au>Vereerstraeten, Pierre</au><au>Abramowicz, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2011-07</date><risdate>2011</risdate><volume>25</volume><issue>4</issue><spage>576</spage><epage>583</epage><pages>576-583</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>Kianda MN, Wissing KM, Broeders NE, Lemy A, Ghisdal L, Hoang AD, Mikhalski D, Donckier V, Vereerstraeten P, Abramowicz D. Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients.
Clin Transplant 2011: 25: 576–583. © 2010 John Wiley & Sons A/S.
: Little is known about the proportion of renal transplant candidates who are considered ineligible by the transplant center, the reasons of their ineligibility and their survival during dialysis. In this retrospective, single‐center study of 445 adult patients referred between 2001 and 2006, 36 (8%) were deemed ineligible for medical contraindications. The leading reason was cardiovascular (CV) (75%), specifically aorto‐iliac, and/or limb vessels atheromatosis or calcifications; ischemic heart disease; or a combination thereof. Nine patients had other contraindications that were absolute for three of them; six patients displayed a combination of relative contraindications. When compared to eligible patients (N = 409), those ineligible were significantly older (60 yr vs. 48), more often diabetics (50% vs. 15%), obese (39% vs. 17%) suffering from coronary artery disease (53% vs. 11%) and peripheral arterial disease (86% vs. 11%). Their primary nephropathy was more often diabetic and/or hypertensive/nephroangiosclerosis (61% vs. 23%), and their median dialysis vintage prior to evaluation was longer (29 months vs. 10, p < 0.0001). The actuarial survival of ineligible patients was significantly lower than that of eligible patients (at five yr: 53% vs. 88%). Adequate control of CV risk factors before dialysis and early referral for transplantation might help to improve eligibility of renal transplant candidates.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>20718825</pmid><doi>10.1111/j.1399-0012.2010.01317.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Clinical transplantation, 2011-07, Vol.25 (4), p.576-583 |
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| subjects | Adult Belgium - epidemiology Biological and medical sciences Cohort Studies Epidemiology Female Fundamental and applied biological sciences. Psychology Fundamental immunology General aspects Humans ineligibility Kidney Failure, Chronic - epidemiology Kidney Failure, Chronic - etiology Kidney Failure, Chronic - surgery Kidney Transplantation Male Medical sciences Middle Aged Patient Selection Prevalence Public health. Hygiene Public health. Hygiene-occupational medicine renal transplantation Retrospective Studies Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the urinary system survival Survival Rate Tissue, organ and graft immunology transplant evaluation Treatment Outcome wait listing |
| title | Ineligibility for renal transplantation: prevalence, causes and survival in a consecutive cohort of 445 patients |
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