VEGF gene polymorphism association with diabetic foot ulcer
Abstract Objective Functional polymorphisms within vascular endothelial growth factor (VEGF) gene have shown association with various conditions including diabetic neuropathy and retinopathy. In this study we have performed a candidate gene association study in order to examine VEGF gene polymorphis...
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| Veröffentlicht in: | Diabetes research and clinical practice 2011-08, Vol.93 (2), p.215-219 |
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| creator | Amoli, Mahsa M Hasani-Ranjbar, Shirin Roohipour, Nahid Sayahpour, Forough A Amiri, Parvin Zahedi, Parisa Mehrab-Mohseni, Mahdie Heshmat, Ramin Larijani, Bagher Tavakkoly-Bazzaz, Javad |
| description | Abstract Objective Functional polymorphisms within vascular endothelial growth factor (VEGF) gene have shown association with various conditions including diabetic neuropathy and retinopathy. In this study we have performed a candidate gene association study in order to examine VEGF gene polymorphism association with diabetic foot ulcer (DFU). Methods The study group comprised of type 2 diabetes patients with ( N = 247) and without ( N = 241) DFU. Healthy control subjects ( N = 98) were also recruited from the same area. The ARMS-PCR technique was applied for genotyping of VEGF gene SNPs at positions −7*C/T and −2578*C/A. Results The frequency of genotype AA was significantly decreased in patients with DFU compared with diabetic subjects without DFU (AA vs CA + CC, p = 0.003, OR = 0.44, CI = 0.24–0.80). Also there was a significant decrease in frequency of A allele in patients with DFU compared to the controls ( p = 0.02, OR = 0.68, CI = 0.48–0.96). Conclusion It seems that lower frequency of A allele in patients with DFU is conferring a protective effect which might be as a result of increased angiogenesis in patients carrying this allele. |
| doi_str_mv | 10.1016/j.diabres.2011.04.016 |
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In this study we have performed a candidate gene association study in order to examine VEGF gene polymorphism association with diabetic foot ulcer (DFU). Methods The study group comprised of type 2 diabetes patients with ( N = 247) and without ( N = 241) DFU. Healthy control subjects ( N = 98) were also recruited from the same area. The ARMS-PCR technique was applied for genotyping of VEGF gene SNPs at positions −7*C/T and −2578*C/A. Results The frequency of genotype AA was significantly decreased in patients with DFU compared with diabetic subjects without DFU (AA vs CA + CC, p = 0.003, OR = 0.44, CI = 0.24–0.80). Also there was a significant decrease in frequency of A allele in patients with DFU compared to the controls ( p = 0.02, OR = 0.68, CI = 0.48–0.96). Conclusion It seems that lower frequency of A allele in patients with DFU is conferring a protective effect which might be as a result of increased angiogenesis in patients carrying this allele.</description><identifier>ISSN: 0168-8227</identifier><identifier>EISSN: 1872-8227</identifier><identifier>DOI: 10.1016/j.diabres.2011.04.016</identifier><identifier>PMID: 21596454</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Aged ; Alleles ; Case-Control Studies ; Diabetic Foot - epidemiology ; Diabetic Foot - genetics ; Diabetic foot ulcer ; Endocrinology & Metabolism ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Iran ; Male ; Middle Aged ; Polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Vascular Endothelial Growth Factor A - genetics ; VEGF</subject><ispartof>Diabetes research and clinical practice, 2011-08, Vol.93 (2), p.215-219</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-2b862966b71d8fb81186c101a62d9e2d859fc7af552d9a8c3ca01bc612c769f73</citedby><cites>FETCH-LOGICAL-c419t-2b862966b71d8fb81186c101a62d9e2d859fc7af552d9a8c3ca01bc612c769f73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S016882271100221X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21596454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amoli, Mahsa M</creatorcontrib><creatorcontrib>Hasani-Ranjbar, Shirin</creatorcontrib><creatorcontrib>Roohipour, Nahid</creatorcontrib><creatorcontrib>Sayahpour, Forough A</creatorcontrib><creatorcontrib>Amiri, Parvin</creatorcontrib><creatorcontrib>Zahedi, Parisa</creatorcontrib><creatorcontrib>Mehrab-Mohseni, Mahdie</creatorcontrib><creatorcontrib>Heshmat, Ramin</creatorcontrib><creatorcontrib>Larijani, Bagher</creatorcontrib><creatorcontrib>Tavakkoly-Bazzaz, Javad</creatorcontrib><title>VEGF gene polymorphism association with diabetic foot ulcer</title><title>Diabetes research and clinical practice</title><addtitle>Diabetes Res Clin Pract</addtitle><description>Abstract Objective Functional polymorphisms within vascular endothelial growth factor (VEGF) gene have shown association with various conditions including diabetic neuropathy and retinopathy. In this study we have performed a candidate gene association study in order to examine VEGF gene polymorphism association with diabetic foot ulcer (DFU). Methods The study group comprised of type 2 diabetes patients with ( N = 247) and without ( N = 241) DFU. Healthy control subjects ( N = 98) were also recruited from the same area. The ARMS-PCR technique was applied for genotyping of VEGF gene SNPs at positions −7*C/T and −2578*C/A. Results The frequency of genotype AA was significantly decreased in patients with DFU compared with diabetic subjects without DFU (AA vs CA + CC, p = 0.003, OR = 0.44, CI = 0.24–0.80). Also there was a significant decrease in frequency of A allele in patients with DFU compared to the controls ( p = 0.02, OR = 0.68, CI = 0.48–0.96). Conclusion It seems that lower frequency of A allele in patients with DFU is conferring a protective effect which might be as a result of increased angiogenesis in patients carrying this allele.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Case-Control Studies</subject><subject>Diabetic Foot - epidemiology</subject><subject>Diabetic Foot - genetics</subject><subject>Diabetic foot ulcer</subject><subject>Endocrinology & Metabolism</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Iran</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Vascular Endothelial Growth Factor A - genetics</subject><subject>VEGF</subject><issn>0168-8227</issn><issn>1872-8227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9P3DAQxS1UBFvgI1Dl1tMGj5M4jiq1qhD_JCQOQNWb5Uwm4G0Sb-2Ear99HXbLgUtPHj-9maf5DWOnwFPgIM9WaWNN7SmkggOkPE-juscWoEqxVEKUH9giKuq1PmQfQ1hxzmWWFwfsUEBRybzIF-zLj4ury-SJBkrWrtv0zq-fbegTE4JDa0brhuSPHZ-TOY1Gi0nr3JhMHZI_Zvut6QKd7N4j9nh58XB-vby9u7o5_367xByqcSlqJUUlZV1Co9paASiJcQcjRVORaFRRtViatiji3yjM0HCoUYLAUlZtmR2xz9u5a-9-TxRG3duA1HVmIDcFrVSmcgUqi85i60TvQvDU6rW3vfEbDVzP2PRK77DpGZvmuY5q7Pu0S5jqnpq3rn-couHb1kBxzxdLXge0NCA11hOOunH2vxFf303Azg4WTfeLNhRWbvJDhKhBB6G5vp9vN58OgHMh4Gf2FxAklO0</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Amoli, Mahsa M</creator><creator>Hasani-Ranjbar, Shirin</creator><creator>Roohipour, Nahid</creator><creator>Sayahpour, Forough A</creator><creator>Amiri, Parvin</creator><creator>Zahedi, Parisa</creator><creator>Mehrab-Mohseni, Mahdie</creator><creator>Heshmat, Ramin</creator><creator>Larijani, Bagher</creator><creator>Tavakkoly-Bazzaz, Javad</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>VEGF gene polymorphism association with diabetic foot ulcer</title><author>Amoli, Mahsa M ; Hasani-Ranjbar, Shirin ; Roohipour, Nahid ; Sayahpour, Forough A ; Amiri, Parvin ; Zahedi, Parisa ; Mehrab-Mohseni, Mahdie ; Heshmat, Ramin ; Larijani, Bagher ; Tavakkoly-Bazzaz, Javad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-2b862966b71d8fb81186c101a62d9e2d859fc7af552d9a8c3ca01bc612c769f73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Case-Control Studies</topic><topic>Diabetic Foot - epidemiology</topic><topic>Diabetic Foot - genetics</topic><topic>Diabetic foot ulcer</topic><topic>Endocrinology & Metabolism</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Iran</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Vascular Endothelial Growth Factor A - genetics</topic><topic>VEGF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amoli, Mahsa M</creatorcontrib><creatorcontrib>Hasani-Ranjbar, Shirin</creatorcontrib><creatorcontrib>Roohipour, Nahid</creatorcontrib><creatorcontrib>Sayahpour, Forough A</creatorcontrib><creatorcontrib>Amiri, Parvin</creatorcontrib><creatorcontrib>Zahedi, Parisa</creatorcontrib><creatorcontrib>Mehrab-Mohseni, Mahdie</creatorcontrib><creatorcontrib>Heshmat, Ramin</creatorcontrib><creatorcontrib>Larijani, Bagher</creatorcontrib><creatorcontrib>Tavakkoly-Bazzaz, Javad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes research and clinical practice</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amoli, Mahsa M</au><au>Hasani-Ranjbar, Shirin</au><au>Roohipour, Nahid</au><au>Sayahpour, Forough A</au><au>Amiri, Parvin</au><au>Zahedi, Parisa</au><au>Mehrab-Mohseni, Mahdie</au><au>Heshmat, Ramin</au><au>Larijani, Bagher</au><au>Tavakkoly-Bazzaz, Javad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>VEGF gene polymorphism association with diabetic foot ulcer</atitle><jtitle>Diabetes research and clinical practice</jtitle><addtitle>Diabetes Res Clin Pract</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>93</volume><issue>2</issue><spage>215</spage><epage>219</epage><pages>215-219</pages><issn>0168-8227</issn><eissn>1872-8227</eissn><abstract>Abstract Objective Functional polymorphisms within vascular endothelial growth factor (VEGF) gene have shown association with various conditions including diabetic neuropathy and retinopathy. In this study we have performed a candidate gene association study in order to examine VEGF gene polymorphism association with diabetic foot ulcer (DFU). Methods The study group comprised of type 2 diabetes patients with ( N = 247) and without ( N = 241) DFU. Healthy control subjects ( N = 98) were also recruited from the same area. The ARMS-PCR technique was applied for genotyping of VEGF gene SNPs at positions −7*C/T and −2578*C/A. Results The frequency of genotype AA was significantly decreased in patients with DFU compared with diabetic subjects without DFU (AA vs CA + CC, p = 0.003, OR = 0.44, CI = 0.24–0.80). Also there was a significant decrease in frequency of A allele in patients with DFU compared to the controls ( p = 0.02, OR = 0.68, CI = 0.48–0.96). Conclusion It seems that lower frequency of A allele in patients with DFU is conferring a protective effect which might be as a result of increased angiogenesis in patients carrying this allele.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>21596454</pmid><doi>10.1016/j.diabres.2011.04.016</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Aged Alleles Case-Control Studies Diabetic Foot - epidemiology Diabetic Foot - genetics Diabetic foot ulcer Endocrinology & Metabolism Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Iran Male Middle Aged Polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide Vascular Endothelial Growth Factor A - genetics VEGF |
| title | VEGF gene polymorphism association with diabetic foot ulcer |
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