Reticular angiomatoid “malignant” fibrous histiocytoma—a case report with cytogenetics and molecular genetic analyses
Summary Angiomatoid “malignant” fibrous histiocytoma is a rare sarcoma of low malignant potential that occurs most commonly in the extremities of children and young adults. Herein, we present a case of angiomatoid malignant fibrous histiocytoma with unusual histologic features arising in the mediast...
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| Veröffentlicht in: | Human pathology 2011-09, Vol.42 (9), p.1359-1363 |
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| creator | Moura, Rafael D., MD Wang, Xiaoke, MS Lonzo, Melissa L., MS Erickson-Johnson, Michele R., MS García, Joaquín J., MD Oliveira, Andre M., MD |
| description | Summary Angiomatoid “malignant” fibrous histiocytoma is a rare sarcoma of low malignant potential that occurs most commonly in the extremities of children and young adults. Herein, we present a case of angiomatoid malignant fibrous histiocytoma with unusual histologic features arising in the mediastinum of an 80-year-old man. The tumor exhibited a reticular growth pattern and myxoid stroma. The tumor cells expressed epithelial membrane antigen and desmin. Cytogenetic analysis revealed the translocation t(2;22)(q33;q12). Molecular genetic analysis confirmed the rearrangement of the EWSR1 locus and the presence of the EWSR1/CREB1 fusion. This report expands the clinicopathologic spectrum of angiomatoid malignant fibrous histiocytoma and underscores the value of integrating morphologic, immunophenotypic, and molecular findings in the identification of its unusual morphologic variants. |
| doi_str_mv | 10.1016/j.humpath.2010.12.003 |
| format | Article |
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Herein, we present a case of angiomatoid malignant fibrous histiocytoma with unusual histologic features arising in the mediastinum of an 80-year-old man. The tumor exhibited a reticular growth pattern and myxoid stroma. The tumor cells expressed epithelial membrane antigen and desmin. Cytogenetic analysis revealed the translocation t(2;22)(q33;q12). Molecular genetic analysis confirmed the rearrangement of the EWSR1 locus and the presence of the EWSR1/CREB1 fusion. This report expands the clinicopathologic spectrum of angiomatoid malignant fibrous histiocytoma and underscores the value of integrating morphologic, immunophenotypic, and molecular findings in the identification of its unusual morphologic variants.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/j.humpath.2010.12.003</identifier><identifier>PMID: 21411119</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged, 80 and over ; Angiomatoid “malignant” fibrous histiocytoma ; Biological and medical sciences ; Calmodulin-Binding Proteins - genetics ; Chromosomes, Human, Pair 2 - genetics ; Chromosomes, Human, Pair 22 - genetics ; CREB1 ; Cyclic AMP Response Element-Binding Protein - genetics ; Cytogenetic Analysis ; EWSR1 ; Histiocytoma, Malignant Fibrous - genetics ; Histiocytoma, Malignant Fibrous - pathology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Mediastinal Neoplasms - genetics ; Mediastinal Neoplasms - pathology ; Mediastinum ; Medical sciences ; Oncogene Proteins, Fusion - genetics ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; RNA-Binding Protein EWS ; RNA-Binding Proteins - genetics ; Translocation, Genetic</subject><ispartof>Human pathology, 2011-09, Vol.42 (9), p.1359-1363</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-ad38b07a9ba3118ea1d14ef7ed3a5edbe102728e1389d43d7f295a624920eefd3</citedby><cites>FETCH-LOGICAL-c449t-ad38b07a9ba3118ea1d14ef7ed3a5edbe102728e1389d43d7f295a624920eefd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0046817710004533$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24462799$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21411119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moura, Rafael D., MD</creatorcontrib><creatorcontrib>Wang, Xiaoke, MS</creatorcontrib><creatorcontrib>Lonzo, Melissa L., MS</creatorcontrib><creatorcontrib>Erickson-Johnson, Michele R., MS</creatorcontrib><creatorcontrib>García, Joaquín J., MD</creatorcontrib><creatorcontrib>Oliveira, Andre M., MD</creatorcontrib><title>Reticular angiomatoid “malignant” fibrous histiocytoma—a case report with cytogenetics and molecular genetic analyses</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Summary Angiomatoid “malignant” fibrous histiocytoma is a rare sarcoma of low malignant potential that occurs most commonly in the extremities of children and young adults. Herein, we present a case of angiomatoid malignant fibrous histiocytoma with unusual histologic features arising in the mediastinum of an 80-year-old man. The tumor exhibited a reticular growth pattern and myxoid stroma. The tumor cells expressed epithelial membrane antigen and desmin. Cytogenetic analysis revealed the translocation t(2;22)(q33;q12). Molecular genetic analysis confirmed the rearrangement of the EWSR1 locus and the presence of the EWSR1/CREB1 fusion. This report expands the clinicopathologic spectrum of angiomatoid malignant fibrous histiocytoma and underscores the value of integrating morphologic, immunophenotypic, and molecular findings in the identification of its unusual morphologic variants.</description><subject>Aged, 80 and over</subject><subject>Angiomatoid “malignant” fibrous histiocytoma</subject><subject>Biological and medical sciences</subject><subject>Calmodulin-Binding Proteins - genetics</subject><subject>Chromosomes, Human, Pair 2 - genetics</subject><subject>Chromosomes, Human, Pair 22 - genetics</subject><subject>CREB1</subject><subject>Cyclic AMP Response Element-Binding Protein - genetics</subject><subject>Cytogenetic Analysis</subject><subject>EWSR1</subject><subject>Histiocytoma, Malignant Fibrous - genetics</subject><subject>Histiocytoma, Malignant Fibrous - pathology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Mediastinal Neoplasms - genetics</subject><subject>Mediastinal Neoplasms - pathology</subject><subject>Mediastinum</subject><subject>Medical sciences</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>RNA-Binding Protein EWS</subject><subject>RNA-Binding Proteins - genetics</subject><subject>Translocation, Genetic</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksuKFDEUhoMoTjv6CEptxFW1udVtowyDNxgQvKzDqeRUd9qqSpuklMZNP4RLfbl-ElN0qeDGbBL-fOc_yc8h5CGja0ZZ-XS33k7DHuJ2zems8TWl4hZZsULwvBYNv01WlMoyr1lVXZB7IewoZayQxV1ywZlkaTUr8u0dRqunHnwG48a6AaKzJjsdfwzQ280IYzwdf2adbb2bQra1IVqnDzGBp-N3yDQEzDzunY_ZVxu32Xy3wXF2DcnSZIPr8dxgkZMK_SFguE_udNAHfLDsl-Tjyxcfrl_nN29fvbm-usm1lE3MwYi6pRU0LQjGagRmmMSuQiOgQNMio7ziNTJRN0YKU3W8KaDksuEUsTPikjw5--69-zxhiGqwQWPfw4jpU6quRS0rUTaJLM6k9i4Ej53aezuAPyhG1Ry72qkldjXHrhhXKfZU92jpMLUDmj9Vv3NOwOMFgKCh7zyM2oa_nJQlr5qZe37mMOXxxaJXQVscNRrrUUdlnP3vU57946B7O9rU9BMeMOzc5FP8QTEVUoF6P8_IPCKMplMhhPgF0S6-ew</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Moura, Rafael D., MD</creator><creator>Wang, Xiaoke, MS</creator><creator>Lonzo, Melissa L., MS</creator><creator>Erickson-Johnson, Michele R., MS</creator><creator>García, Joaquín J., MD</creator><creator>Oliveira, Andre M., MD</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Reticular angiomatoid “malignant” fibrous histiocytoma—a case report with cytogenetics and molecular genetic analyses</title><author>Moura, Rafael D., MD ; Wang, Xiaoke, MS ; Lonzo, Melissa L., MS ; Erickson-Johnson, Michele R., MS ; García, Joaquín J., MD ; Oliveira, Andre M., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-ad38b07a9ba3118ea1d14ef7ed3a5edbe102728e1389d43d7f295a624920eefd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged, 80 and over</topic><topic>Angiomatoid “malignant” fibrous histiocytoma</topic><topic>Biological and medical sciences</topic><topic>Calmodulin-Binding Proteins - genetics</topic><topic>Chromosomes, Human, Pair 2 - genetics</topic><topic>Chromosomes, Human, Pair 22 - genetics</topic><topic>CREB1</topic><topic>Cyclic AMP Response Element-Binding Protein - genetics</topic><topic>Cytogenetic Analysis</topic><topic>EWSR1</topic><topic>Histiocytoma, Malignant Fibrous - genetics</topic><topic>Histiocytoma, Malignant Fibrous - pathology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Mediastinal Neoplasms - genetics</topic><topic>Mediastinal Neoplasms - pathology</topic><topic>Mediastinum</topic><topic>Medical sciences</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>RNA-Binding Protein EWS</topic><topic>RNA-Binding Proteins - genetics</topic><topic>Translocation, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moura, Rafael D., MD</creatorcontrib><creatorcontrib>Wang, Xiaoke, MS</creatorcontrib><creatorcontrib>Lonzo, Melissa L., MS</creatorcontrib><creatorcontrib>Erickson-Johnson, Michele R., MS</creatorcontrib><creatorcontrib>García, Joaquín J., MD</creatorcontrib><creatorcontrib>Oliveira, Andre M., MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moura, Rafael D., MD</au><au>Wang, Xiaoke, MS</au><au>Lonzo, Melissa L., MS</au><au>Erickson-Johnson, Michele R., MS</au><au>García, Joaquín J., MD</au><au>Oliveira, Andre M., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reticular angiomatoid “malignant” fibrous histiocytoma—a case report with cytogenetics and molecular genetic analyses</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>42</volume><issue>9</issue><spage>1359</spage><epage>1363</epage><pages>1359-1363</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Summary Angiomatoid “malignant” fibrous histiocytoma is a rare sarcoma of low malignant potential that occurs most commonly in the extremities of children and young adults. Herein, we present a case of angiomatoid malignant fibrous histiocytoma with unusual histologic features arising in the mediastinum of an 80-year-old man. The tumor exhibited a reticular growth pattern and myxoid stroma. The tumor cells expressed epithelial membrane antigen and desmin. Cytogenetic analysis revealed the translocation t(2;22)(q33;q12). Molecular genetic analysis confirmed the rearrangement of the EWSR1 locus and the presence of the EWSR1/CREB1 fusion. This report expands the clinicopathologic spectrum of angiomatoid malignant fibrous histiocytoma and underscores the value of integrating morphologic, immunophenotypic, and molecular findings in the identification of its unusual morphologic variants.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21411119</pmid><doi>10.1016/j.humpath.2010.12.003</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged, 80 and over Angiomatoid “malignant” fibrous histiocytoma Biological and medical sciences Calmodulin-Binding Proteins - genetics Chromosomes, Human, Pair 2 - genetics Chromosomes, Human, Pair 22 - genetics CREB1 Cyclic AMP Response Element-Binding Protein - genetics Cytogenetic Analysis EWSR1 Histiocytoma, Malignant Fibrous - genetics Histiocytoma, Malignant Fibrous - pathology Humans Investigative techniques, diagnostic techniques (general aspects) Male Mediastinal Neoplasms - genetics Mediastinal Neoplasms - pathology Mediastinum Medical sciences Oncogene Proteins, Fusion - genetics Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques RNA-Binding Protein EWS RNA-Binding Proteins - genetics Translocation, Genetic |
| title | Reticular angiomatoid “malignant” fibrous histiocytoma—a case report with cytogenetics and molecular genetic analyses |
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