Liquid chromatography-tandem mass spectroscopic method for the determination of zerumbone in human plasma and its application to pharmacokinetics

A rapid, sensitive, specific and selective LC–MS/MS method for the determination of zerumbone (ZER) in human plasma using 2,4‐diamino‐6‐(4‐methoxyphenyl)‐1,3,5‐triazine (DMTZ) as an internal standard (IS) has been developed and validated. ZER was chromatographed on C8 column using a mobile phase of...

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Veröffentlicht in:	Journal of mass spectrometry. 2011-08, Vol.46 (8), p.772-781
Hauptverfasser:	Eid, Eltayeb E. M., Bustamam Abdul, Ahmad, Rasedee, A., Suliman, Fakhr Eldin O., Sukari, Mohd A., Fatah, Safa A.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Hydroxypropyl-beta-cyclodextrin Acetonitriles Analysis Analysis of Variance Animals beta-Cyclodextrins - chemistry Bias Biological and medical sciences Calibration Carboxymethylcellulose Sodium - chemistry Chromatography Chromatography, Liquid - methods Drug Stability General pharmacology Human human plasma Humans hydroxypropyl-β-cyclodextrin Least-Squares Analysis Liquids Male Medical sciences Monitoring pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Sesquiterpenes - administration & dosage Sesquiterpenes - blood Sesquiterpenes - pharmacokinetics Sodium carboxymethyl cellulose Spectrometry, Mass, Electrospray Ionization tandem mass spectrometry Tandem Mass Spectrometry - methods zerumbone
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