Increased serum and bone matrix levels of transforming growth factor {beta}1 in patients with GH deficiency in response to GH treatment

Patients with adult onset GH deficiency (aoGHD) have secondary osteoporosis, which is reversed by long-term GH substitution. Transforming growth factor β1 (TGFβ1 or TGFB1) is abundant in bone tissue and could mediate some effects of GH/IGFs on bone. We investigated its regulation by GH/IGF1 in vivo...

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Veröffentlicht in:	European journal of endocrinology 2011-09, Vol.165 (3), p.393-400
Hauptverfasser:	Ueland, Thor, Lekva, Tove, Otterdal, Kari, Dahl, Tuva B, Olarescu, Nicoleta Cristina, Jørgensen, Anders P, Fougner, Kristian J, Brixen, Kim, Aukrust, Pål, Bollerslev, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Adult Bone Matrix - metabolism Cell Line Female Human Growth Hormone - deficiency Human Growth Hormone - therapeutic use Humans Insulin-Like Growth Factor I - therapeutic use Macrophages - drug effects Macrophages - metabolism Male Middle Aged Osteoblasts - drug effects Osteoblasts - metabolism Osteoporosis - drug therapy Transforming Growth Factor beta1 - metabolism
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