Lopinavir/ritonavir resistance in patients infected with HIV-1: two divergent resistance pathways?

The HIV‐1 protease L76V mutation has been described recently as conferring high‐level resistance to lopinavir/ritonavir (LPV/r). The aim was to identify the factors and particularly protease mutations associated with the presence of L76V in treatment‐experienced patients infected with HIV‐1 who have...

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Veröffentlicht in:	Journal of medical virology 2011-10, Vol.83 (10), p.1677-1681
Hauptverfasser:	Champenois, Karen, Baras, Agathe, Choisy, Philippe, Ajana, Faiza, Melliez, Hughes, Bocket, Laurence, Yazdanpanah, Yazdan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biological and medical sciences Drug Resistance, Viral - genetics Drug therapy Female Fundamental and applied biological sciences. Psychology Genotype HIV HIV Infections - drug therapy HIV Infections - mortality HIV Infections - virology HIV Protease - genetics HIV Protease Inhibitors - pharmacology HIV Protease Inhibitors - therapeutic use HIV-1 - drug effects HIV-1 - genetics HIV-1 - metabolism HIV-1 infection Human immunodeficiency virus Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases L76V Lopinavir - pharmacology Lopinavir - therapeutic use lopinavir/ritonavir Male Medical sciences Microbiology Middle Aged Miscellaneous Multivariate analysis Mutation protease inhibitor protease resistance mutation Retrospective Studies Ritonavir - pharmacology Ritonavir - therapeutic use RNA, Viral - genetics Viral diseases Virology
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