Antibody response and avidity of respiratory syncytial virus-specific total IgG, IgG1, and IgG3 in young children
Respiratory syncytial virus (RSV) is a major cause of acute respiratory disease in infants and young children. Considering that several aspects of the humoral immune response to RSV infection remain unclear, this study aimed to investigate the occurrence, levels, and avidity of total IgG, IgG1, and...
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| Veröffentlicht in: | Journal of medical virology 2011-10, Vol.83 (10), p.1826-1833 |
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| creator | Freitas, G.R.O. Silva, D.A.O. Yokosawa, J. Paula, N.T. Costa, L.F. Carneiro, B.M. Ribeiro, L.Z.G. Oliveira, T.F.M. Mineo, J.R. Queiróz, D.A.O. |
| description | Respiratory syncytial virus (RSV) is a major cause of acute respiratory disease in infants and young children. Considering that several aspects of the humoral immune response to RSV infection remain unclear, this study aimed to investigate the occurrence, levels, and avidity of total IgG, IgG1, and IgG3 antibodies against RSV in serum samples from children ≤5 years old. In addition, a possible association between antibody avidity and severity of illness was examined. The occurrence and levels of RSV‐specific IgG depended on age, with infants |
| doi_str_mv | 10.1002/jmv.22134 |
| format | Article |
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Considering that several aspects of the humoral immune response to RSV infection remain unclear, this study aimed to investigate the occurrence, levels, and avidity of total IgG, IgG1, and IgG3 antibodies against RSV in serum samples from children ≤5 years old. In addition, a possible association between antibody avidity and severity of illness was examined. The occurrence and levels of RSV‐specific IgG depended on age, with infants <3 months old displaying high levels of antibodies, which were probably acquired from the mother. Children ≥24 months old also showed frequent occurrence and high levels of IgG, which was produced actively during infection. In addition, the avidity assay showed that the avidity of RSV‐specific total IgG and IgG1 was lower in infants <3 months old who had acute respiratory disease than in age‐matched controls. The avidity of RSV‐specific IgG detected in children ≥24 months old with lower respiratory infection was lower than that in children with upper respiratory infection. These results indicate that the presence of high avidity RSV‐specific IgG antibodies may lead to better protection against RSV infection in children <3 months old, who may have a lower probability of developing disease of increased severity. In addition, children ≥24 months old with RSV‐specific IgG antibodies of low avidity tended to develop more severe RSV illness. These findings may be helpful in establishing vaccination schedules when a vaccine becomes available. J. Med. Virol. 83:1826–1833, 2011. © 2011 Wiley‐Liss, Inc.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.22134</identifier><identifier>PMID: 21837801</identifier><identifier>CODEN: JMVIDB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>acute respiratory disease ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Antibody Affinity ; avidity assay ; Biological and medical sciences ; Child, Preschool ; Enzyme-Linked Immunosorbent Assay ; Female ; Fundamental and applied biological sciences. Psychology ; Human viral diseases ; Humans ; IgG antibody subclasses ; Immunoglobulin G - blood ; Immunoglobulin G - classification ; Immunoglobulin G - immunology ; Infant ; Infections ; Infectious diseases ; Male ; Medical research ; Medical sciences ; Microbiology ; Miscellaneous ; Respiratory diseases ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - immunology ; Respiratory Syncytial Viruses - immunology ; Respiratory Tract Infections - immunology ; Respiratory Tract Infections - virology ; Severity of Illness Index ; Viral diseases ; Virology</subject><ispartof>Journal of medical virology, 2011-10, Vol.83 (10), p.1826-1833</ispartof><rights>Copyright © 2011 Wiley‐Liss, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4534-db45619b94206b8329252b9189024be7396311369be62f9d19249bea328838e03</citedby><cites>FETCH-LOGICAL-c4534-db45619b94206b8329252b9189024be7396311369be62f9d19249bea328838e03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjmv.22134$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjmv.22134$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24441687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21837801$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freitas, G.R.O.</creatorcontrib><creatorcontrib>Silva, D.A.O.</creatorcontrib><creatorcontrib>Yokosawa, J.</creatorcontrib><creatorcontrib>Paula, N.T.</creatorcontrib><creatorcontrib>Costa, L.F.</creatorcontrib><creatorcontrib>Carneiro, B.M.</creatorcontrib><creatorcontrib>Ribeiro, L.Z.G.</creatorcontrib><creatorcontrib>Oliveira, T.F.M.</creatorcontrib><creatorcontrib>Mineo, J.R.</creatorcontrib><creatorcontrib>Queiróz, D.A.O.</creatorcontrib><title>Antibody response and avidity of respiratory syncytial virus-specific total IgG, IgG1, and IgG3 in young children</title><title>Journal of medical virology</title><addtitle>J. Med. Virol</addtitle><description>Respiratory syncytial virus (RSV) is a major cause of acute respiratory disease in infants and young children. Considering that several aspects of the humoral immune response to RSV infection remain unclear, this study aimed to investigate the occurrence, levels, and avidity of total IgG, IgG1, and IgG3 antibodies against RSV in serum samples from children ≤5 years old. In addition, a possible association between antibody avidity and severity of illness was examined. The occurrence and levels of RSV‐specific IgG depended on age, with infants <3 months old displaying high levels of antibodies, which were probably acquired from the mother. Children ≥24 months old also showed frequent occurrence and high levels of IgG, which was produced actively during infection. In addition, the avidity assay showed that the avidity of RSV‐specific total IgG and IgG1 was lower in infants <3 months old who had acute respiratory disease than in age‐matched controls. The avidity of RSV‐specific IgG detected in children ≥24 months old with lower respiratory infection was lower than that in children with upper respiratory infection. These results indicate that the presence of high avidity RSV‐specific IgG antibodies may lead to better protection against RSV infection in children <3 months old, who may have a lower probability of developing disease of increased severity. In addition, children ≥24 months old with RSV‐specific IgG antibodies of low avidity tended to develop more severe RSV illness. These findings may be helpful in establishing vaccination schedules when a vaccine becomes available. J. Med. Virol. 83:1826–1833, 2011. © 2011 Wiley‐Liss, Inc.</description><subject>acute respiratory disease</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Antibody Affinity</subject><subject>avidity assay</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>IgG antibody subclasses</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin G - classification</subject><subject>Immunoglobulin G - immunology</subject><subject>Infant</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Respiratory diseases</subject><subject>Respiratory syncytial virus</subject><subject>Respiratory Syncytial Virus Infections - immunology</subject><subject>Respiratory Syncytial Viruses - immunology</subject><subject>Respiratory Tract Infections - immunology</subject><subject>Respiratory Tract Infections - virology</subject><subject>Severity of Illness Index</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90d1rFDEQAPAgij2rD_4DEhBRodtmkmw2eSytnpX68aD1MWR3szXnXnJNdk_3vzf30QqCEkiG4TczhEHoKZBjIISeLJbrY0qB8XtoBkSJQpEK7qMZAS4KIaA8QI9SWhBCpKL0ITqgIFklCczQzakfXB3aCUebVsEni41vsVm71g0TDt0276IZQpxwmnwzDc70eO3imIq0so3rXIOHMOTkxfX8aHPB0bZJjhh2Hk9h9Ne4-e76Nlr_GD3oTJ_sk_17iL6-ffPl7F1x-Wl-cXZ6WTS8ZLxoa14KULXilIhaMqpoSWsFUhHKa1sxJRgAE6q2gnaqBUV5jg2jUjJpCTtEL3d9VzHcjDYNeulSY_veeBvGpDNjRNJKZfnqvxJKQYDmA5k-_4suwhh9_kdWvCSylHIz-vVONTGkFG2nV9EtTZw0EL3ZmM4b09uNZfts33Gsl7a9k7cryuDFHpjUmL6Lxjcu_XGccxCyyu5k53663k7_nqjff7i6HV3sKlwa7K-7ChN_aFGxqtTfPs41OS_5FVSf9Tn7DTqyuFo</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Freitas, G.R.O.</creator><creator>Silva, D.A.O.</creator><creator>Yokosawa, J.</creator><creator>Paula, N.T.</creator><creator>Costa, L.F.</creator><creator>Carneiro, B.M.</creator><creator>Ribeiro, L.Z.G.</creator><creator>Oliveira, T.F.M.</creator><creator>Mineo, J.R.</creator><creator>Queiróz, D.A.O.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Antibody response and avidity of respiratory syncytial virus-specific total IgG, IgG1, and IgG3 in young children</title><author>Freitas, G.R.O. ; Silva, D.A.O. ; Yokosawa, J. ; Paula, N.T. ; Costa, L.F. ; Carneiro, B.M. ; Ribeiro, L.Z.G. ; Oliveira, T.F.M. ; Mineo, J.R. ; Queiróz, D.A.O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4534-db45619b94206b8329252b9189024be7396311369be62f9d19249bea328838e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>acute respiratory disease</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>Antibody Affinity</topic><topic>avidity assay</topic><topic>Biological and medical sciences</topic><topic>Child, Preschool</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>IgG antibody subclasses</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin G - classification</topic><topic>Immunoglobulin G - immunology</topic><topic>Infant</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Respiratory diseases</topic><topic>Respiratory syncytial virus</topic><topic>Respiratory Syncytial Virus Infections - immunology</topic><topic>Respiratory Syncytial Viruses - immunology</topic><topic>Respiratory Tract Infections - immunology</topic><topic>Respiratory Tract Infections - virology</topic><topic>Severity of Illness Index</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freitas, G.R.O.</creatorcontrib><creatorcontrib>Silva, D.A.O.</creatorcontrib><creatorcontrib>Yokosawa, J.</creatorcontrib><creatorcontrib>Paula, N.T.</creatorcontrib><creatorcontrib>Costa, L.F.</creatorcontrib><creatorcontrib>Carneiro, B.M.</creatorcontrib><creatorcontrib>Ribeiro, L.Z.G.</creatorcontrib><creatorcontrib>Oliveira, T.F.M.</creatorcontrib><creatorcontrib>Mineo, J.R.</creatorcontrib><creatorcontrib>Queiróz, D.A.O.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freitas, G.R.O.</au><au>Silva, D.A.O.</au><au>Yokosawa, J.</au><au>Paula, N.T.</au><au>Costa, L.F.</au><au>Carneiro, B.M.</au><au>Ribeiro, L.Z.G.</au><au>Oliveira, T.F.M.</au><au>Mineo, J.R.</au><au>Queiróz, D.A.O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antibody response and avidity of respiratory syncytial virus-specific total IgG, IgG1, and IgG3 in young children</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J. Med. Virol</addtitle><date>2011-10</date><risdate>2011</risdate><volume>83</volume><issue>10</issue><spage>1826</spage><epage>1833</epage><pages>1826-1833</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><coden>JMVIDB</coden><abstract>Respiratory syncytial virus (RSV) is a major cause of acute respiratory disease in infants and young children. Considering that several aspects of the humoral immune response to RSV infection remain unclear, this study aimed to investigate the occurrence, levels, and avidity of total IgG, IgG1, and IgG3 antibodies against RSV in serum samples from children ≤5 years old. In addition, a possible association between antibody avidity and severity of illness was examined. The occurrence and levels of RSV‐specific IgG depended on age, with infants <3 months old displaying high levels of antibodies, which were probably acquired from the mother. Children ≥24 months old also showed frequent occurrence and high levels of IgG, which was produced actively during infection. In addition, the avidity assay showed that the avidity of RSV‐specific total IgG and IgG1 was lower in infants <3 months old who had acute respiratory disease than in age‐matched controls. The avidity of RSV‐specific IgG detected in children ≥24 months old with lower respiratory infection was lower than that in children with upper respiratory infection. These results indicate that the presence of high avidity RSV‐specific IgG antibodies may lead to better protection against RSV infection in children <3 months old, who may have a lower probability of developing disease of increased severity. In addition, children ≥24 months old with RSV‐specific IgG antibodies of low avidity tended to develop more severe RSV illness. These findings may be helpful in establishing vaccination schedules when a vaccine becomes available. J. Med. Virol. 83:1826–1833, 2011. © 2011 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21837801</pmid><doi>10.1002/jmv.22134</doi><tpages>8</tpages></addata></record> |
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| subjects | acute respiratory disease Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Affinity avidity assay Biological and medical sciences Child, Preschool Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Human viral diseases Humans IgG antibody subclasses Immunoglobulin G - blood Immunoglobulin G - classification Immunoglobulin G - immunology Infant Infections Infectious diseases Male Medical research Medical sciences Microbiology Miscellaneous Respiratory diseases Respiratory syncytial virus Respiratory Syncytial Virus Infections - immunology Respiratory Syncytial Viruses - immunology Respiratory Tract Infections - immunology Respiratory Tract Infections - virology Severity of Illness Index Viral diseases Virology |
| title | Antibody response and avidity of respiratory syncytial virus-specific total IgG, IgG1, and IgG3 in young children |
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