Reversible optic neuropathy related to disulfiram
To report a case of bilateral optic neuropathy, possibly caused by disulfiram. Clinical case report. A 46-year-old patient, treated with disulfiram for the past 4 years for chronic alcoholism, presented with progressive bilateral, painless, severe visual loss, related to optic neuropathy. An extensi...
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| Veröffentlicht in: | Journal francais d'ophtalmologie 2011-06, Vol.34 (6), p.382.e1-382.e3 |
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| container_end_page | 382.e3 |
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| container_issue | 6 |
| container_start_page | 382.e1 |
| container_title | Journal francais d'ophtalmologie |
| container_volume | 34 |
| creator | Trélohan, A Milea, D |
| description | To report a case of bilateral optic neuropathy, possibly caused by disulfiram.
Clinical case report.
A 46-year-old patient, treated with disulfiram for the past 4 years for chronic alcoholism, presented with progressive bilateral, painless, severe visual loss, related to optic neuropathy. An extensive work-up did not disclose any other possible cause than a toxic optic neuropathy caused by disulfiram. Discontinuation of disulfiram resulted in rapid, complete visual recovery.
Disulfiram can cause toxic optic neuropathy, which can recover after discontinuing the medication, even after a long period of intoxication. |
| doi_str_mv | 10.1016/j.jfo.2010.11.019 |
| format | Article |
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Clinical case report.
A 46-year-old patient, treated with disulfiram for the past 4 years for chronic alcoholism, presented with progressive bilateral, painless, severe visual loss, related to optic neuropathy. An extensive work-up did not disclose any other possible cause than a toxic optic neuropathy caused by disulfiram. Discontinuation of disulfiram resulted in rapid, complete visual recovery.
Disulfiram can cause toxic optic neuropathy, which can recover after discontinuing the medication, even after a long period of intoxication.</description><identifier>EISSN: 1773-0597</identifier><identifier>DOI: 10.1016/j.jfo.2010.11.019</identifier><identifier>PMID: 21507508</identifier><language>fre</language><publisher>France</publisher><subject>Alcohol Deterrents - adverse effects ; Alcoholism - drug therapy ; Color Vision Defects - chemically induced ; Disulfiram - adverse effects ; Humans ; Male ; Middle Aged ; Optic Nerve Diseases - chemically induced ; Recovery of Function - physiology ; Visual Acuity - drug effects</subject><ispartof>Journal francais d'ophtalmologie, 2011-06, Vol.34 (6), p.382.e1-382.e3</ispartof><rights>Copyright © 2011 Elsevier Masson SAS. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21507508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trélohan, A</creatorcontrib><creatorcontrib>Milea, D</creatorcontrib><title>Reversible optic neuropathy related to disulfiram</title><title>Journal francais d'ophtalmologie</title><addtitle>J Fr Ophtalmol</addtitle><description>To report a case of bilateral optic neuropathy, possibly caused by disulfiram.
Clinical case report.
A 46-year-old patient, treated with disulfiram for the past 4 years for chronic alcoholism, presented with progressive bilateral, painless, severe visual loss, related to optic neuropathy. An extensive work-up did not disclose any other possible cause than a toxic optic neuropathy caused by disulfiram. Discontinuation of disulfiram resulted in rapid, complete visual recovery.
Disulfiram can cause toxic optic neuropathy, which can recover after discontinuing the medication, even after a long period of intoxication.</description><subject>Alcohol Deterrents - adverse effects</subject><subject>Alcoholism - drug therapy</subject><subject>Color Vision Defects - chemically induced</subject><subject>Disulfiram - adverse effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Optic Nerve Diseases - chemically induced</subject><subject>Recovery of Function - physiology</subject><subject>Visual Acuity - drug effects</subject><issn>1773-0597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1j09LxDAUxIMg7rLuB_AivXlqfUmavuQoi_9gQRA9l7R5xS7tpiapsN_einoaZubHwDB2xaHgwKvbQ3HofCHgx_MCuDlja44oc1AGV2wbY98saSVQKX7BVoIrQAV6zfgrfVFY6oEyP6W-zY40Bz_Z9HHKAg02kcuSz1wf56Hrgx0v2Xlnh0jbP92w94f7t91Tvn95fN7d7fOJl5By12oEck6AJmqNK6UERcIJB1qZkoOBBpEMSawaC9pI49AIUk1TVmXVyQ27-d2dgv-cKaZ67GNLw2CP5OdYa70sYqlwIa__yLkZydVT6EcbTvX_S_kN6ydS_A</recordid><startdate>201106</startdate><enddate>201106</enddate><creator>Trélohan, A</creator><creator>Milea, D</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201106</creationdate><title>Reversible optic neuropathy related to disulfiram</title><author>Trélohan, A ; Milea, D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p140t-dc870edd208eec9d43305e2d2d085941090b77e9e376ba08939d792e5bb4646f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>fre</language><creationdate>2011</creationdate><topic>Alcohol Deterrents - adverse effects</topic><topic>Alcoholism - drug therapy</topic><topic>Color Vision Defects - chemically induced</topic><topic>Disulfiram - adverse effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Optic Nerve Diseases - chemically induced</topic><topic>Recovery of Function - physiology</topic><topic>Visual Acuity - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Trélohan, A</creatorcontrib><creatorcontrib>Milea, D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal francais d'ophtalmologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trélohan, A</au><au>Milea, D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reversible optic neuropathy related to disulfiram</atitle><jtitle>Journal francais d'ophtalmologie</jtitle><addtitle>J Fr Ophtalmol</addtitle><date>2011-06</date><risdate>2011</risdate><volume>34</volume><issue>6</issue><spage>382.e1</spage><epage>382.e3</epage><pages>382.e1-382.e3</pages><eissn>1773-0597</eissn><abstract>To report a case of bilateral optic neuropathy, possibly caused by disulfiram.
Clinical case report.
A 46-year-old patient, treated with disulfiram for the past 4 years for chronic alcoholism, presented with progressive bilateral, painless, severe visual loss, related to optic neuropathy. An extensive work-up did not disclose any other possible cause than a toxic optic neuropathy caused by disulfiram. Discontinuation of disulfiram resulted in rapid, complete visual recovery.
Disulfiram can cause toxic optic neuropathy, which can recover after discontinuing the medication, even after a long period of intoxication.</abstract><cop>France</cop><pmid>21507508</pmid><doi>10.1016/j.jfo.2010.11.019</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1773-0597 |
| ispartof | Journal francais d'ophtalmologie, 2011-06, Vol.34 (6), p.382.e1-382.e3 |
| issn | 1773-0597 |
| language | fre |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Alcohol Deterrents - adverse effects Alcoholism - drug therapy Color Vision Defects - chemically induced Disulfiram - adverse effects Humans Male Middle Aged Optic Nerve Diseases - chemically induced Recovery of Function - physiology Visual Acuity - drug effects |
| title | Reversible optic neuropathy related to disulfiram |
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