Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells
Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific diffe...
Gespeichert in:
| Veröffentlicht in: | ACS nano 2011-06, Vol.5 (6), p.4670-4678 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4678 |
|---|---|
| container_issue | 6 |
| container_start_page | 4670 |
| container_title | ACS nano |
| container_volume | 5 |
| creator | Nayak, Tapas R Andersen, Henrik Makam, Venkata S Khaw, Clement Bae, Sukang Xu, Xiangfan Ee, Pui-Lai R Ahn, Jong-Hyun Hong, Byung Hee Pastorin, Giorgia Özyilmaz, Barbaros |
| description | Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells’ proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphene’s potential for stem cell research. |
| doi_str_mv | 10.1021/nn200500h |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_883307431</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>883307431</sourcerecordid><originalsourceid>FETCH-LOGICAL-a380t-7586289db79ea7d728b95bd2fa8c3e07cbc27d35ca0efbf9209058a5f2c22b7a3</originalsourceid><addsrcrecordid>eNpt0D1PwzAQBmALgWgpDPwB5AUhhoBjN7EzVuGjSEUdAIktsp0zTZXYxXaG_nuCWjox3Z306JXuRegyJXcpoem9tZSQjJDVERqnBcsTIvLP48OepSN0FsJ6MFzw_BSNaJpRIabFGKlnLzcrsICN87h0NnrXtlBjaWs80xpa8DIO9zJEcF9gG40fGmPAg42NjI2z2Bk87ztp8SsEsHq17WSL3yJ0uIS2DefoxMg2wMV-TtDH0-N7OU8Wy-eXcrZIJBMkJjwTORVFrXgBktecClVkqqZGCs2AcK005TXLtCRglCkoKUgmZGaoplRxySboZpe78e67hxCrrgnDA6204PpQCcEY4VOWDvJ2J7V3IXgw1cY3nfTbKiXVb6PVodHBXu1Te9VBfZB_FQ7gegekDtXa9d4OT_4T9AP1FH36</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>883307431</pqid></control><display><type>article</type><title>Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells</title><source>MEDLINE</source><source>American Chemical Society Journals</source><creator>Nayak, Tapas R ; Andersen, Henrik ; Makam, Venkata S ; Khaw, Clement ; Bae, Sukang ; Xu, Xiangfan ; Ee, Pui-Lai R ; Ahn, Jong-Hyun ; Hong, Byung Hee ; Pastorin, Giorgia ; Özyilmaz, Barbaros</creator><creatorcontrib>Nayak, Tapas R ; Andersen, Henrik ; Makam, Venkata S ; Khaw, Clement ; Bae, Sukang ; Xu, Xiangfan ; Ee, Pui-Lai R ; Ahn, Jong-Hyun ; Hong, Byung Hee ; Pastorin, Giorgia ; Özyilmaz, Barbaros</creatorcontrib><description>Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells’ proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphene’s potential for stem cell research.</description><identifier>ISSN: 1936-0851</identifier><identifier>EISSN: 1936-086X</identifier><identifier>DOI: 10.1021/nn200500h</identifier><identifier>PMID: 21528849</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Biocompatible Materials - chemistry ; Bone and Bones - pathology ; Cartilage - pathology ; Cell Culture Techniques ; Cell Differentiation ; Cell Proliferation ; Cell Survival ; Dimethylpolysiloxanes - chemistry ; Graphite - chemistry ; Humans ; Mesenchymal Stromal Cells - cytology ; Microscopy, Atomic Force - methods ; Nylons - chemistry ; Osteogenesis ; Pressure ; Tissue Engineering</subject><ispartof>ACS nano, 2011-06, Vol.5 (6), p.4670-4678</ispartof><rights>Copyright © 2011 American Chemical Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a380t-7586289db79ea7d728b95bd2fa8c3e07cbc27d35ca0efbf9209058a5f2c22b7a3</citedby><cites>FETCH-LOGICAL-a380t-7586289db79ea7d728b95bd2fa8c3e07cbc27d35ca0efbf9209058a5f2c22b7a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/nn200500h$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/nn200500h$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21528849$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nayak, Tapas R</creatorcontrib><creatorcontrib>Andersen, Henrik</creatorcontrib><creatorcontrib>Makam, Venkata S</creatorcontrib><creatorcontrib>Khaw, Clement</creatorcontrib><creatorcontrib>Bae, Sukang</creatorcontrib><creatorcontrib>Xu, Xiangfan</creatorcontrib><creatorcontrib>Ee, Pui-Lai R</creatorcontrib><creatorcontrib>Ahn, Jong-Hyun</creatorcontrib><creatorcontrib>Hong, Byung Hee</creatorcontrib><creatorcontrib>Pastorin, Giorgia</creatorcontrib><creatorcontrib>Özyilmaz, Barbaros</creatorcontrib><title>Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells</title><title>ACS nano</title><addtitle>ACS Nano</addtitle><description>Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells’ proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphene’s potential for stem cell research.</description><subject>Biocompatible Materials - chemistry</subject><subject>Bone and Bones - pathology</subject><subject>Cartilage - pathology</subject><subject>Cell Culture Techniques</subject><subject>Cell Differentiation</subject><subject>Cell Proliferation</subject><subject>Cell Survival</subject><subject>Dimethylpolysiloxanes - chemistry</subject><subject>Graphite - chemistry</subject><subject>Humans</subject><subject>Mesenchymal Stromal Cells - cytology</subject><subject>Microscopy, Atomic Force - methods</subject><subject>Nylons - chemistry</subject><subject>Osteogenesis</subject><subject>Pressure</subject><subject>Tissue Engineering</subject><issn>1936-0851</issn><issn>1936-086X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0D1PwzAQBmALgWgpDPwB5AUhhoBjN7EzVuGjSEUdAIktsp0zTZXYxXaG_nuCWjox3Z306JXuRegyJXcpoem9tZSQjJDVERqnBcsTIvLP48OepSN0FsJ6MFzw_BSNaJpRIabFGKlnLzcrsICN87h0NnrXtlBjaWs80xpa8DIO9zJEcF9gG40fGmPAg42NjI2z2Bk87ztp8SsEsHq17WSL3yJ0uIS2DefoxMg2wMV-TtDH0-N7OU8Wy-eXcrZIJBMkJjwTORVFrXgBktecClVkqqZGCs2AcK005TXLtCRglCkoKUgmZGaoplRxySboZpe78e67hxCrrgnDA6204PpQCcEY4VOWDvJ2J7V3IXgw1cY3nfTbKiXVb6PVodHBXu1Te9VBfZB_FQ7gegekDtXa9d4OT_4T9AP1FH36</recordid><startdate>20110628</startdate><enddate>20110628</enddate><creator>Nayak, Tapas R</creator><creator>Andersen, Henrik</creator><creator>Makam, Venkata S</creator><creator>Khaw, Clement</creator><creator>Bae, Sukang</creator><creator>Xu, Xiangfan</creator><creator>Ee, Pui-Lai R</creator><creator>Ahn, Jong-Hyun</creator><creator>Hong, Byung Hee</creator><creator>Pastorin, Giorgia</creator><creator>Özyilmaz, Barbaros</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110628</creationdate><title>Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells</title><author>Nayak, Tapas R ; Andersen, Henrik ; Makam, Venkata S ; Khaw, Clement ; Bae, Sukang ; Xu, Xiangfan ; Ee, Pui-Lai R ; Ahn, Jong-Hyun ; Hong, Byung Hee ; Pastorin, Giorgia ; Özyilmaz, Barbaros</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a380t-7586289db79ea7d728b95bd2fa8c3e07cbc27d35ca0efbf9209058a5f2c22b7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biocompatible Materials - chemistry</topic><topic>Bone and Bones - pathology</topic><topic>Cartilage - pathology</topic><topic>Cell Culture Techniques</topic><topic>Cell Differentiation</topic><topic>Cell Proliferation</topic><topic>Cell Survival</topic><topic>Dimethylpolysiloxanes - chemistry</topic><topic>Graphite - chemistry</topic><topic>Humans</topic><topic>Mesenchymal Stromal Cells - cytology</topic><topic>Microscopy, Atomic Force - methods</topic><topic>Nylons - chemistry</topic><topic>Osteogenesis</topic><topic>Pressure</topic><topic>Tissue Engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nayak, Tapas R</creatorcontrib><creatorcontrib>Andersen, Henrik</creatorcontrib><creatorcontrib>Makam, Venkata S</creatorcontrib><creatorcontrib>Khaw, Clement</creatorcontrib><creatorcontrib>Bae, Sukang</creatorcontrib><creatorcontrib>Xu, Xiangfan</creatorcontrib><creatorcontrib>Ee, Pui-Lai R</creatorcontrib><creatorcontrib>Ahn, Jong-Hyun</creatorcontrib><creatorcontrib>Hong, Byung Hee</creatorcontrib><creatorcontrib>Pastorin, Giorgia</creatorcontrib><creatorcontrib>Özyilmaz, Barbaros</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS nano</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nayak, Tapas R</au><au>Andersen, Henrik</au><au>Makam, Venkata S</au><au>Khaw, Clement</au><au>Bae, Sukang</au><au>Xu, Xiangfan</au><au>Ee, Pui-Lai R</au><au>Ahn, Jong-Hyun</au><au>Hong, Byung Hee</au><au>Pastorin, Giorgia</au><au>Özyilmaz, Barbaros</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells</atitle><jtitle>ACS nano</jtitle><addtitle>ACS Nano</addtitle><date>2011-06-28</date><risdate>2011</risdate><volume>5</volume><issue>6</issue><spage>4670</spage><epage>4678</epage><pages>4670-4678</pages><issn>1936-0851</issn><eissn>1936-086X</eissn><abstract>Current tissue engineering approaches combine different scaffold materials with living cells to provide biological substitutes that can repair and eventually improve tissue functions. Both natural and synthetic materials have been fabricated for transplantation of stem cells and their specific differentiation into muscles, bones, and cartilages. One of the key objectives for bone regeneration therapy to be successful is to direct stem cells’ proliferation and to accelerate their differentiation in a controlled manner through the use of growth factors and osteogenic inducers. Here we show that graphene provides a promising biocompatible scaffold that does not hamper the proliferation of human mesenchymal stem cells (hMSCs) and accelerates their specific differentiation into bone cells. The differentiation rate is comparable to the one achieved with common growth factors, demonstrating graphene’s potential for stem cell research.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>21528849</pmid><doi>10.1021/nn200500h</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1936-0851 |
| ispartof | ACS nano, 2011-06, Vol.5 (6), p.4670-4678 |
| issn | 1936-0851 1936-086X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_883307431 |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Biocompatible Materials - chemistry Bone and Bones - pathology Cartilage - pathology Cell Culture Techniques Cell Differentiation Cell Proliferation Cell Survival Dimethylpolysiloxanes - chemistry Graphite - chemistry Humans Mesenchymal Stromal Cells - cytology Microscopy, Atomic Force - methods Nylons - chemistry Osteogenesis Pressure Tissue Engineering |
| title | Graphene for Controlled and Accelerated Osteogenic Differentiation of Human Mesenchymal Stem Cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A46%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Graphene%20for%20Controlled%20and%20Accelerated%20Osteogenic%20Differentiation%20of%20Human%20Mesenchymal%20Stem%20Cells&rft.jtitle=ACS%20nano&rft.au=Nayak,%20Tapas%20R&rft.date=2011-06-28&rft.volume=5&rft.issue=6&rft.spage=4670&rft.epage=4678&rft.pages=4670-4678&rft.issn=1936-0851&rft.eissn=1936-086X&rft_id=info:doi/10.1021/nn200500h&rft_dat=%3Cproquest_cross%3E883307431%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=883307431&rft_id=info:pmid/21528849&rfr_iscdi=true |