Metabotropic glutamate receptors in the thalamocortical network: Strategic targets for the treatment of absence epilepsy
Summary Metabotropic glutamate (mGlu) receptors are positioned at synapses of the thalamocortical network that underlie the development of spike‐and‐wave discharges (SWDs) associated with absence epilepsy. The modulatory role of individual mGlu receptor subtypes on excitatory and inhibitory synaptic...
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| Veröffentlicht in: | Epilepsia (Copenhagen) 2011-07, Vol.52 (7), p.1211-1222 |
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| container_title | Epilepsia (Copenhagen) |
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| creator | Ngomba, Richard Teke Santolini, Ines Salt, Thomas E. Ferraguti, Francesco Battaglia, Giuseppe Nicoletti, Ferdinando van Luijtelaar, Gilles |
| description | Summary
Metabotropic glutamate (mGlu) receptors are positioned at synapses of the thalamocortical network that underlie the development of spike‐and‐wave discharges (SWDs) associated with absence epilepsy. The modulatory role of individual mGlu receptor subtypes on excitatory and inhibitory synaptic transmission in the cortico‐thalamo‐cortical circuitry makes subtype‐selective mGlu receptor ligands potential candidates as novel antiabsence drugs. Some of these compounds are under clinical development for the treatment of numerous neurologic and psychiatric disorders, and might be soon available for clinical studies in patients with absence seizures refractory to conventional medications. Herein we review the growing evidence that links mGlu receptors to the pathophysiology of pathologic SWDs moving from the anatomic localization and function of distinct mGlu receptor subtypes in the cortico‐thalamo‐cortical network to in vivo studies in mouse and rat models of absence epilepsy. |
| doi_str_mv | 10.1111/j.1528-1167.2011.03082.x |
| format | Article |
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Metabotropic glutamate (mGlu) receptors are positioned at synapses of the thalamocortical network that underlie the development of spike‐and‐wave discharges (SWDs) associated with absence epilepsy. The modulatory role of individual mGlu receptor subtypes on excitatory and inhibitory synaptic transmission in the cortico‐thalamo‐cortical circuitry makes subtype‐selective mGlu receptor ligands potential candidates as novel antiabsence drugs. Some of these compounds are under clinical development for the treatment of numerous neurologic and psychiatric disorders, and might be soon available for clinical studies in patients with absence seizures refractory to conventional medications. Herein we review the growing evidence that links mGlu receptors to the pathophysiology of pathologic SWDs moving from the anatomic localization and function of distinct mGlu receptor subtypes in the cortico‐thalamo‐cortical network to in vivo studies in mouse and rat models of absence epilepsy.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/j.1528-1167.2011.03082.x</identifier><identifier>PMID: 21569017</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Absence seizures ; Animals ; Anticonvulsants - pharmacology ; Anticonvulsants - therapeutic use ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Cerebral Cortex - drug effects ; Cerebral Cortex - physiology ; Cortex ; Disease Models, Animal ; Drug development ; Drugs ; Epilepsy ; Epilepsy, Absence - drug therapy ; Glutamic acid receptors ; Glutamic acid receptors (metabotropic) ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Medical sciences ; Mental disorders ; mGlu receptors ; Mice ; Nerve Net - drug effects ; Nerve Net - physiology ; Nervous system (semeiology, syndromes) ; Neuroglia - drug effects ; Neuroglia - physiology ; Neurology ; Neuropharmacology ; Pharmacology. Drug treatments ; Rats ; Receptor mechanisms ; Receptors, Metabotropic Glutamate - drug effects ; Receptors, Metabotropic Glutamate - physiology ; Seizures ; Spike‐wave discharges ; Synapses ; Synaptic transmission ; Thalamus ; Thalamus - drug effects ; Thalamus - physiology ; WAG/Rij rat model</subject><ispartof>Epilepsia (Copenhagen), 2011-07, Vol.52 (7), p.1211-1222</ispartof><rights>Wiley Periodicals, Inc. © 2011 International League Against Epilepsy</rights><rights>2015 INIST-CNRS</rights><rights>Wiley Periodicals, Inc. © 2011 International League Against Epilepsy.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5252-2c649bce00403340a2dddadd7991b04840f71318cf45a5687e35f97d62ed9f713</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1528-1167.2011.03082.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1528-1167.2011.03082.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24383615$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21569017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ngomba, Richard Teke</creatorcontrib><creatorcontrib>Santolini, Ines</creatorcontrib><creatorcontrib>Salt, Thomas E.</creatorcontrib><creatorcontrib>Ferraguti, Francesco</creatorcontrib><creatorcontrib>Battaglia, Giuseppe</creatorcontrib><creatorcontrib>Nicoletti, Ferdinando</creatorcontrib><creatorcontrib>van Luijtelaar, Gilles</creatorcontrib><title>Metabotropic glutamate receptors in the thalamocortical network: Strategic targets for the treatment of absence epilepsy</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Metabotropic glutamate (mGlu) receptors are positioned at synapses of the thalamocortical network that underlie the development of spike‐and‐wave discharges (SWDs) associated with absence epilepsy. The modulatory role of individual mGlu receptor subtypes on excitatory and inhibitory synaptic transmission in the cortico‐thalamo‐cortical circuitry makes subtype‐selective mGlu receptor ligands potential candidates as novel antiabsence drugs. Some of these compounds are under clinical development for the treatment of numerous neurologic and psychiatric disorders, and might be soon available for clinical studies in patients with absence seizures refractory to conventional medications. Herein we review the growing evidence that links mGlu receptors to the pathophysiology of pathologic SWDs moving from the anatomic localization and function of distinct mGlu receptor subtypes in the cortico‐thalamo‐cortical network to in vivo studies in mouse and rat models of absence epilepsy.</description><subject>Absence seizures</subject><subject>Animals</subject><subject>Anticonvulsants - pharmacology</subject><subject>Anticonvulsants - therapeutic use</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Biological and medical sciences</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - physiology</subject><subject>Cortex</subject><subject>Disease Models, Animal</subject><subject>Drug development</subject><subject>Drugs</subject><subject>Epilepsy</subject><subject>Epilepsy, Absence - drug therapy</subject><subject>Glutamic acid receptors</subject><subject>Glutamic acid receptors (metabotropic)</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mental disorders</subject><subject>mGlu receptors</subject><subject>Mice</subject><subject>Nerve Net - drug effects</subject><subject>Nerve Net - physiology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neuroglia - drug effects</subject><subject>Neuroglia - physiology</subject><subject>Neurology</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Receptor mechanisms</subject><subject>Receptors, Metabotropic Glutamate - drug effects</subject><subject>Receptors, Metabotropic Glutamate - physiology</subject><subject>Seizures</subject><subject>Spike‐wave discharges</subject><subject>Synapses</subject><subject>Synaptic transmission</subject><subject>Thalamus</subject><subject>Thalamus - drug effects</subject><subject>Thalamus - physiology</subject><subject>WAG/Rij rat model</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFklGL1DAUhYMo7rj6FyQg4lPrTdK0qeDDsqzrwoqC-hzS9Hbs2DY1SdmZf2-6M67gi4GQwPnuhXvuIYQyyFk6b3c5k1xljJVVzoGxHAQonu8fkc2D8JhsAJjIaqngjDwLYQcAVVmJp-SMM1nWwKoN2X_CaBoXvZt7S7fDEs1oIlKPFufofKD9ROMPTNcMZnTW-dhbM9AJ453zP9_Rr9Gngm2qjsZvMQbaOX8s8WjiiFOkrqOmCThZpDj3A87h8Jw86cwQ8MXpPSffP1x9u_yY3X6-vrm8uM2s5JJn3JZF3VgEKECIAgxv29a0bVXXrIFCFdBVTDBlu0IaWaoKhezqqi05tvUqnZM3x76zd78WDFGPfbA4DGZCtwStlEhthCz_T1ayUErWPJGv_iF3bvFTGkMzySouEgaJenmilmbEVs--H40_6D_mJ-D1CTAhWdp5M9k-_OUKoUTJZOLeH7m7ZN3hQWeg1zDonV53rted6zUM-j4Meq-vvtysP_EbAamnyQ</recordid><startdate>201107</startdate><enddate>201107</enddate><creator>Ngomba, Richard Teke</creator><creator>Santolini, Ines</creator><creator>Salt, Thomas E.</creator><creator>Ferraguti, Francesco</creator><creator>Battaglia, Giuseppe</creator><creator>Nicoletti, Ferdinando</creator><creator>van Luijtelaar, Gilles</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201107</creationdate><title>Metabotropic glutamate receptors in the thalamocortical network: Strategic targets for the treatment of absence epilepsy</title><author>Ngomba, Richard Teke ; Santolini, Ines ; Salt, Thomas E. ; Ferraguti, Francesco ; Battaglia, Giuseppe ; Nicoletti, Ferdinando ; van Luijtelaar, Gilles</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5252-2c649bce00403340a2dddadd7991b04840f71318cf45a5687e35f97d62ed9f713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Absence seizures</topic><topic>Animals</topic><topic>Anticonvulsants - pharmacology</topic><topic>Anticonvulsants - therapeutic use</topic><topic>Anticonvulsants. Antiepileptics. Antiparkinson agents</topic><topic>Biological and medical sciences</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - physiology</topic><topic>Cortex</topic><topic>Disease Models, Animal</topic><topic>Drug development</topic><topic>Drugs</topic><topic>Epilepsy</topic><topic>Epilepsy, Absence - drug therapy</topic><topic>Glutamic acid receptors</topic><topic>Glutamic acid receptors (metabotropic)</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mental disorders</topic><topic>mGlu receptors</topic><topic>Mice</topic><topic>Nerve Net - drug effects</topic><topic>Nerve Net - physiology</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neuroglia - drug effects</topic><topic>Neuroglia - physiology</topic><topic>Neurology</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Receptor mechanisms</topic><topic>Receptors, Metabotropic Glutamate - drug effects</topic><topic>Receptors, Metabotropic Glutamate - physiology</topic><topic>Seizures</topic><topic>Spike‐wave discharges</topic><topic>Synapses</topic><topic>Synaptic transmission</topic><topic>Thalamus</topic><topic>Thalamus - drug effects</topic><topic>Thalamus - physiology</topic><topic>WAG/Rij rat model</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ngomba, Richard Teke</creatorcontrib><creatorcontrib>Santolini, Ines</creatorcontrib><creatorcontrib>Salt, Thomas E.</creatorcontrib><creatorcontrib>Ferraguti, Francesco</creatorcontrib><creatorcontrib>Battaglia, Giuseppe</creatorcontrib><creatorcontrib>Nicoletti, Ferdinando</creatorcontrib><creatorcontrib>van Luijtelaar, Gilles</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ngomba, Richard Teke</au><au>Santolini, Ines</au><au>Salt, Thomas E.</au><au>Ferraguti, Francesco</au><au>Battaglia, Giuseppe</au><au>Nicoletti, Ferdinando</au><au>van Luijtelaar, Gilles</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabotropic glutamate receptors in the thalamocortical network: Strategic targets for the treatment of absence epilepsy</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2011-07</date><risdate>2011</risdate><volume>52</volume><issue>7</issue><spage>1211</spage><epage>1222</epage><pages>1211-1222</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Metabotropic glutamate (mGlu) receptors are positioned at synapses of the thalamocortical network that underlie the development of spike‐and‐wave discharges (SWDs) associated with absence epilepsy. The modulatory role of individual mGlu receptor subtypes on excitatory and inhibitory synaptic transmission in the cortico‐thalamo‐cortical circuitry makes subtype‐selective mGlu receptor ligands potential candidates as novel antiabsence drugs. Some of these compounds are under clinical development for the treatment of numerous neurologic and psychiatric disorders, and might be soon available for clinical studies in patients with absence seizures refractory to conventional medications. Herein we review the growing evidence that links mGlu receptors to the pathophysiology of pathologic SWDs moving from the anatomic localization and function of distinct mGlu receptor subtypes in the cortico‐thalamo‐cortical network to in vivo studies in mouse and rat models of absence epilepsy.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21569017</pmid><doi>10.1111/j.1528-1167.2011.03082.x</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Absence seizures Animals Anticonvulsants - pharmacology Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Cerebral Cortex - drug effects Cerebral Cortex - physiology Cortex Disease Models, Animal Drug development Drugs Epilepsy Epilepsy, Absence - drug therapy Glutamic acid receptors Glutamic acid receptors (metabotropic) Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Medical sciences Mental disorders mGlu receptors Mice Nerve Net - drug effects Nerve Net - physiology Nervous system (semeiology, syndromes) Neuroglia - drug effects Neuroglia - physiology Neurology Neuropharmacology Pharmacology. Drug treatments Rats Receptor mechanisms Receptors, Metabotropic Glutamate - drug effects Receptors, Metabotropic Glutamate - physiology Seizures Spike‐wave discharges Synapses Synaptic transmission Thalamus Thalamus - drug effects Thalamus - physiology WAG/Rij rat model |
| title | Metabotropic glutamate receptors in the thalamocortical network: Strategic targets for the treatment of absence epilepsy |
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