Expanding TRAF function: TRAF3 as a tri-faced immune regulator

Key Points TNFR-associated factors (TRAFs) constitute a family of seven cytoplasmic proteins that control signal transduction from different receptor families, including the tumour necrosis factor receptors (TNFRs), Toll-like receptors (TLRs) and RIG-I-like receptors (RLRs). Therefore, TRAFs regulat...

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Veröffentlicht in:	Nature reviews. Immunology 2011-07, Vol.11 (7), p.457-468
Hauptverfasser:	Häcker, Hans, Tseng, Ping-Hui, Karin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/516 631/45/612/1234 Animals Apoptosis Biomedical and Life Sciences Biomedicine Cellular signal transduction Cytokines Genetic aspects Humans Immunology Interferon Type I - metabolism Kinases Mitogen-Activated Protein Kinases - metabolism Models, Biological NF-kappa B - metabolism Physiological aspects Protein kinases Proteins Receptors, Tumor Necrosis Factor - metabolism review-article Signal transduction Signal Transduction - immunology Signal Transduction - physiology TNF Receptor-Associated Factor 3 - immunology TNF Receptor-Associated Factor 3 - physiology Toll-Like Receptors - metabolism Transcription factors Tumor necrosis factor Tumor necrosis factor-TNF
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