Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization

The assessment of the skin sensitising capacity of chemicals is up to now investigated using in vivo animal tests. However there has been an increasing public and governmental concern regarding the use of animals for chemical screening. This has raised the need for the development of validated in vi...

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Veröffentlicht in:	Molecular immunology 2007-05, Vol.44 (12), p.3222-3233
Hauptverfasser:	Schoeters, Elke, Verheyen, Geert R., Nelissen, Inge, Van Rompay, An R., Hooyberghs, Jef, Van Den Heuvel, Rosette L., Witters, Hilda, Schoeters, Greet E.R., Van Tendeloo, Vigor F.I., Berneman, Zwi N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergens Allergens - pharmacology Antigen-presenting cells Benzalkonium chloride Biomarkers CD34 antigen Contact dermatitis Cord blood Dendritic cells Dendritic Cells - drug effects Dermatitis, Contact - diagnosis DNA microarrays eugenol Gene Expression Profiling Gene Expression Regulation - drug effects Gene Expression Regulation - immunology Humans Irritants - pharmacology Langerhans cells Langerhans Cells - drug effects Microarray Nickel Oligonucleotide Array Sequence Analysis oxazolone Polymerase chain reaction RNA-directed DNA polymerase Sensitization Skin Skin - drug effects Skin - immunology Skin Tests
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