In vitro and in vivo evaluation on the bioactivity of ZnO containing nano-hydroxyapatite/chitosan cement
A ZnO containing nano‐hydroxyapatite/chitosan (n‐HA/CS) cement was developed and its bone formation ability was investigated in vitro and in vivo. The physico‐chemical properties of the cement were determined in terms of pH variation during and after setting, injectability and wettability. The resul...
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| Veröffentlicht in: | Journal of biomedical materials research. Part A 2010-04, Vol.93A (1), p.269-279 |
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| creator | Li, Zhang Yubao, Li Yi, Zuo Lan, Wu Jansen, John A. |
| description | A ZnO containing nano‐hydroxyapatite/chitosan (n‐HA/CS) cement was developed and its bone formation ability was investigated in vitro and in vivo. The physico‐chemical properties of the cement were determined in terms of pH variation during and after setting, injectability and wettability. The results indicated that, the pH varied from 7.04 to 7.12 throughout the soaking of the cement in distilled water. The injectability was excellent during the first 4 min, but the cement became less injectable or even not injectable at all after 7 min setting. The static contact angle of the cement against water was 53.5 ± 2.7°. The results of immersion tests in simulated body fluid (SBF) indicated that the cement exhibited excellent bone‐like apatite forming ability. In vivo studies, involving the installation of the cement of tibial‐bone defects in rabbit tibia revealed an inflammatory response around the cement at 3 days of implantation. After 4 weeks, the inflammation began to disappear and the cement had bound to the surrounding host bone. Radiological examination also confirmed that the ZnO containing n‐HA/CS cement significantly induced new bone formation. These results suggest that the ZnO containing n‐HA/CS cement may be beneficial to enhance bone regeneration in osseous defect sites. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2010 |
| doi_str_mv | 10.1002/jbm.a.32500 |
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The physico‐chemical properties of the cement were determined in terms of pH variation during and after setting, injectability and wettability. The results indicated that, the pH varied from 7.04 to 7.12 throughout the soaking of the cement in distilled water. The injectability was excellent during the first 4 min, but the cement became less injectable or even not injectable at all after 7 min setting. The static contact angle of the cement against water was 53.5 ± 2.7°. The results of immersion tests in simulated body fluid (SBF) indicated that the cement exhibited excellent bone‐like apatite forming ability. In vivo studies, involving the installation of the cement of tibial‐bone defects in rabbit tibia revealed an inflammatory response around the cement at 3 days of implantation. After 4 weeks, the inflammation began to disappear and the cement had bound to the surrounding host bone. Radiological examination also confirmed that the ZnO containing n‐HA/CS cement significantly induced new bone formation. These results suggest that the ZnO containing n‐HA/CS cement may be beneficial to enhance bone regeneration in osseous defect sites. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2010</description><identifier>ISSN: 1549-3296</identifier><identifier>ISSN: 1552-4965</identifier><identifier>EISSN: 1552-4965</identifier><identifier>DOI: 10.1002/jbm.a.32500</identifier><identifier>PMID: 19562749</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Bone and Bones - diagnostic imaging ; Bone and Bones - pathology ; Bone Cements - pharmacology ; bone formation ; Calcium - metabolism ; cement ; chitosan ; Chitosan - pharmacology ; Durapatite - pharmacology ; Hydrogen-Ion Concentration - drug effects ; Implants, Experimental ; Medical sciences ; Microscopy, Electron, Scanning ; nano-hydroxyapatite ; Nanoparticles - chemistry ; Orthopedic surgery ; Phosphorus - metabolism ; Rabbits ; Radiography ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Technology. Biomaterials. Equipments ; Time Factors ; Wettability - drug effects ; Zinc Oxide - pharmacology ; ZnO</subject><ispartof>Journal of biomedical materials research. 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Part A</title><addtitle>J. Biomed. Mater. Res</addtitle><description>A ZnO containing nano‐hydroxyapatite/chitosan (n‐HA/CS) cement was developed and its bone formation ability was investigated in vitro and in vivo. The physico‐chemical properties of the cement were determined in terms of pH variation during and after setting, injectability and wettability. The results indicated that, the pH varied from 7.04 to 7.12 throughout the soaking of the cement in distilled water. The injectability was excellent during the first 4 min, but the cement became less injectable or even not injectable at all after 7 min setting. The static contact angle of the cement against water was 53.5 ± 2.7°. The results of immersion tests in simulated body fluid (SBF) indicated that the cement exhibited excellent bone‐like apatite forming ability. In vivo studies, involving the installation of the cement of tibial‐bone defects in rabbit tibia revealed an inflammatory response around the cement at 3 days of implantation. After 4 weeks, the inflammation began to disappear and the cement had bound to the surrounding host bone. Radiological examination also confirmed that the ZnO containing n‐HA/CS cement significantly induced new bone formation. These results suggest that the ZnO containing n‐HA/CS cement may be beneficial to enhance bone regeneration in osseous defect sites. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2010</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone and Bones - diagnostic imaging</subject><subject>Bone and Bones - pathology</subject><subject>Bone Cements - pharmacology</subject><subject>bone formation</subject><subject>Calcium - metabolism</subject><subject>cement</subject><subject>chitosan</subject><subject>Chitosan - pharmacology</subject><subject>Durapatite - pharmacology</subject><subject>Hydrogen-Ion Concentration - drug effects</subject><subject>Implants, Experimental</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>nano-hydroxyapatite</subject><subject>Nanoparticles - chemistry</subject><subject>Orthopedic surgery</subject><subject>Phosphorus - metabolism</subject><subject>Rabbits</subject><subject>Radiography</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Time Factors</subject><subject>Wettability - drug effects</subject><subject>Zinc Oxide - pharmacology</subject><subject>ZnO</subject><issn>1549-3296</issn><issn>1552-4965</issn><issn>1552-4965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UtvEzEUBeARAtFSWLFH3iAW1aR-P5a0oqVVoBtQERvrjsdDXCZ2OnZC598zIaHsqGTJtvTdcxenql4TPCMY05PbZjmDGaMC4yfVIRGC1txI8XT75qZm1MiD6kXOtxOWWNDn1QExQlLFzWG1uIxoE8qQEMQWhe1nk5DfQL-GElJE0ykLj5qQwJUw0RGlDn2P18ilWCDEEH-gCDHVi7Ed0v0Iq2mw-BO3CCVliMj5pY_lZfWsgz77V_v7qPp6_uHL2cd6fn1xefZ-XjsuKa45lZ0DzFvSaKabRrXaSGY6xbXHHmvNlfaceNp0ilGljBBENNx4QsERMOyoerfLXQ3pbu1zscuQne97iD6ts9WaYS6kVo9LaYRSFJNHpWJMMKLNNvN4J92Qch58Z1dDWMIwWoLtti07tWXB_mlr0m_2uetm6dt_dl_PBN7uAWQHfTdAdCE_OEoFl1iyyZGd-xV6P_5vp706_fR3eb2bCbn4-4cZGH5aqZgS9ubzhaXzb_MrJm_sKfsNpsq7QA</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Li, Zhang</creator><creator>Yubao, Li</creator><creator>Yi, Zuo</creator><creator>Lan, Wu</creator><creator>Jansen, John A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201004</creationdate><title>In vitro and in vivo evaluation on the bioactivity of ZnO containing nano-hydroxyapatite/chitosan cement</title><author>Li, Zhang ; Yubao, Li ; Yi, Zuo ; Lan, Wu ; Jansen, John A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4620-426fca04d1b838bb7d89639f748e0e088478e41e2bf7327795515b49e12ac1a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone and Bones - diagnostic imaging</topic><topic>Bone and Bones - pathology</topic><topic>Bone Cements - pharmacology</topic><topic>bone formation</topic><topic>Calcium - metabolism</topic><topic>cement</topic><topic>chitosan</topic><topic>Chitosan - pharmacology</topic><topic>Durapatite - pharmacology</topic><topic>Hydrogen-Ion Concentration - drug effects</topic><topic>Implants, Experimental</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>nano-hydroxyapatite</topic><topic>Nanoparticles - chemistry</topic><topic>Orthopedic surgery</topic><topic>Phosphorus - metabolism</topic><topic>Rabbits</topic><topic>Radiography</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Time Factors</topic><topic>Wettability - drug effects</topic><topic>Zinc Oxide - pharmacology</topic><topic>ZnO</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Zhang</creatorcontrib><creatorcontrib>Yubao, Li</creatorcontrib><creatorcontrib>Yi, Zuo</creatorcontrib><creatorcontrib>Lan, Wu</creatorcontrib><creatorcontrib>Jansen, John A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of biomedical materials research. Part A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Zhang</au><au>Yubao, Li</au><au>Yi, Zuo</au><au>Lan, Wu</au><au>Jansen, John A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro and in vivo evaluation on the bioactivity of ZnO containing nano-hydroxyapatite/chitosan cement</atitle><jtitle>Journal of biomedical materials research. Part A</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2010-04</date><risdate>2010</risdate><volume>93A</volume><issue>1</issue><spage>269</spage><epage>279</epage><pages>269-279</pages><issn>1549-3296</issn><issn>1552-4965</issn><eissn>1552-4965</eissn><abstract>A ZnO containing nano‐hydroxyapatite/chitosan (n‐HA/CS) cement was developed and its bone formation ability was investigated in vitro and in vivo. The physico‐chemical properties of the cement were determined in terms of pH variation during and after setting, injectability and wettability. The results indicated that, the pH varied from 7.04 to 7.12 throughout the soaking of the cement in distilled water. The injectability was excellent during the first 4 min, but the cement became less injectable or even not injectable at all after 7 min setting. The static contact angle of the cement against water was 53.5 ± 2.7°. The results of immersion tests in simulated body fluid (SBF) indicated that the cement exhibited excellent bone‐like apatite forming ability. In vivo studies, involving the installation of the cement of tibial‐bone defects in rabbit tibia revealed an inflammatory response around the cement at 3 days of implantation. After 4 weeks, the inflammation began to disappear and the cement had bound to the surrounding host bone. Radiological examination also confirmed that the ZnO containing n‐HA/CS cement significantly induced new bone formation. These results suggest that the ZnO containing n‐HA/CS cement may be beneficial to enhance bone regeneration in osseous defect sites. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res 2010</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19562749</pmid><doi>10.1002/jbm.a.32500</doi><tpages>11</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Bone and Bones - diagnostic imaging Bone and Bones - pathology Bone Cements - pharmacology bone formation Calcium - metabolism cement chitosan Chitosan - pharmacology Durapatite - pharmacology Hydrogen-Ion Concentration - drug effects Implants, Experimental Medical sciences Microscopy, Electron, Scanning nano-hydroxyapatite Nanoparticles - chemistry Orthopedic surgery Phosphorus - metabolism Rabbits Radiography Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology. Biomaterials. Equipments Time Factors Wettability - drug effects Zinc Oxide - pharmacology ZnO |
| title | In vitro and in vivo evaluation on the bioactivity of ZnO containing nano-hydroxyapatite/chitosan cement |
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