What are the best reference values for a normal serum alanine transaminase activity (ALT)? Impact on the presumed prevalence of drug induced liver injury (DILI)

In clinical research, the definition of the upper limit of normal (ULN) is rarely detailed. For alanine transaminase (ALT), there are several definitions of ULN-ALT but no recognized global reference. Furthermore the inter-laboratory variability of results expressed using ULN-ALT is higher than usin...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2011-08, Vol.60 (3), p.290-295
Hauptverfasser:	M’Kada, Helmi, Munteanu, Mona, Perazzo, Hugo, Ngo, Yen, Ramanujam, Nittia, Imbert-Bismut, Françoise, Ratziu, Vlad, Bonnefont-Rousselot, Dominique, Souberbielle, Bernard, Schuppe-Koistinen, Ina, Poynard, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - blood ALT Biomarkers Chemical and Drug Induced Liver Injury - enzymology DILI Female Humans Hy’s law Limit of the normal Liver Function Tests - methods Liver necrosis Male Middle Aged Reference Values Temple criteria
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