Evaluation of Alloreactivity in Kidney Transplant Recipients Treated with Antithymocyte Globulin Versus IL‐2 Receptor Blocker

Induction therapy is used in kidney transplantation to inhibit the activation of donor‐reactive T cells which are detrimental to transplant outcomes. The choice of induction therapy is decided based on perceived immunological risk rather than by direct measurement of donor T‐cell reactivity. We hypo...

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Veröffentlicht in:	American journal of transplantation 2011-07, Vol.11 (7), p.1388-1396
Hauptverfasser:	Cherkassky, L., Lanning, M., Lalli, P. N., Czerr, J., Siegel, H., Danziger‐Isakov, L., Srinivas, T., Valujskikh, A., Shoskes, D. A., Baldwin, W., Fairchild, R. L., Poggio, E. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - therapeutic use Antilymphocyte Serum - therapeutic use Basiliximab Biological and medical sciences CD4-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - drug effects Donor immunity ELISPOT Enzyme-Linked Immunospot Assay Graft Rejection - immunology Humans induction Kidney Transplantation - immunology Lymphocyte Depletion - methods Medical sciences Prospective Studies Receptors, Interleukin-2 - antagonists & inhibitors Recombinant Fusion Proteins - therapeutic use Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases T-Lymphocytes - immunology thymoglobulin T‐cell
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