Effects of mood stabilizers on brain reward processes in rats: Studies using the intracranial self-stimulation paradigm
Abstract Bipolar disorder is characterized by dysregulated motivation and increased hedonistic drive. d -Amphetamine induces manic symptoms in humans and exacerbates mania in bipolar disorder patients, effects that are counteracted by mood stabilizers. We utilized intracranial self-stimulation (ICSS...
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| Veröffentlicht in: | European neuropsychopharmacology 2009-03, Vol.19 (3), p.205-214 |
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| creator | Mavrikaki, Maria Nomikos, George G Panagis, George |
| description | Abstract Bipolar disorder is characterized by dysregulated motivation and increased hedonistic drive. d -Amphetamine induces manic symptoms in humans and exacerbates mania in bipolar disorder patients, effects that are counteracted by mood stabilizers. We utilized intracranial self-stimulation (ICSS) to examine how lithium (LiCl), valproate (VPA) or their combination that is commonly used in the clinic affect brain reward function in rats, and how these drugs affect d -amphetamine's reward-facilitating effects. Acute intraperitoneal (i.p.) administration of LiCl (100, 200 mg/kg), VPA (400 mg/kg) or combined administration of subthreshold doses of LiCl (50 mg/kg) and VPA (200 mg/kg) increased ICSS thresholds. LiCl (100 mg/kg) and combined administration of LiCl and VPA (50 and 200 mg/kg), but not VPA alone (200, 400 mg/kg), attenuated d -amphetamine's reward-facilitating effects. These results suggest that ICSS combined with d -amphetamine constitutes a useful model to explore the elation and increased hedonistic drive observed in bipolar patients and ultimately help to identify novel pharmacotherapies for bipolar disorder. |
| doi_str_mv | 10.1016/j.euroneuro.2008.11.002 |
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We utilized intracranial self-stimulation (ICSS) to examine how lithium (LiCl), valproate (VPA) or their combination that is commonly used in the clinic affect brain reward function in rats, and how these drugs affect d -amphetamine's reward-facilitating effects. Acute intraperitoneal (i.p.) administration of LiCl (100, 200 mg/kg), VPA (400 mg/kg) or combined administration of subthreshold doses of LiCl (50 mg/kg) and VPA (200 mg/kg) increased ICSS thresholds. LiCl (100 mg/kg) and combined administration of LiCl and VPA (50 and 200 mg/kg), but not VPA alone (200, 400 mg/kg), attenuated d -amphetamine's reward-facilitating effects. These results suggest that ICSS combined with d -amphetamine constitutes a useful model to explore the elation and increased hedonistic drive observed in bipolar patients and ultimately help to identify novel pharmacotherapies for bipolar disorder.</description><identifier>ISSN: 0924-977X</identifier><identifier>EISSN: 1873-7862</identifier><identifier>DOI: 10.1016/j.euroneuro.2008.11.002</identifier><identifier>PMID: 19110403</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Analysis of Variance ; Animal model ; Animals ; Antimanic Agents - administration & dosage ; Behavior, Animal ; Brain - drug effects ; Brain - physiology ; Brain stimulation reward ; Central Nervous System Stimulants - administration & dosage ; Conditioning, Operant - drug effects ; d-Amphetamine ; Dextroamphetamine - administration & dosage ; Dose-Response Relationship, Drug ; Drug Administration Routes ; Drug Combinations ; Internal Medicine ; Lithium Chloride - administration & dosage ; Male ; Mood stabilizers ; Psychiatry ; Rats ; Rats, Sprague-Dawley ; Reinforcement ; Reward ; Self Administration - methods ; Valproic Acid - administration & dosage</subject><ispartof>European neuropsychopharmacology, 2009-03, Vol.19 (3), p.205-214</ispartof><rights>Elsevier B.V.</rights><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-b01276b95318ce9c68ab6b72e643470cae70519a0545c184cc3c1285d6ab4d5b3</citedby><cites>FETCH-LOGICAL-c481t-b01276b95318ce9c68ab6b72e643470cae70519a0545c184cc3c1285d6ab4d5b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.euroneuro.2008.11.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19110403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mavrikaki, Maria</creatorcontrib><creatorcontrib>Nomikos, George G</creatorcontrib><creatorcontrib>Panagis, George</creatorcontrib><title>Effects of mood stabilizers on brain reward processes in rats: Studies using the intracranial self-stimulation paradigm</title><title>European neuropsychopharmacology</title><addtitle>Eur Neuropsychopharmacol</addtitle><description>Abstract Bipolar disorder is characterized by dysregulated motivation and increased hedonistic drive. d -Amphetamine induces manic symptoms in humans and exacerbates mania in bipolar disorder patients, effects that are counteracted by mood stabilizers. We utilized intracranial self-stimulation (ICSS) to examine how lithium (LiCl), valproate (VPA) or their combination that is commonly used in the clinic affect brain reward function in rats, and how these drugs affect d -amphetamine's reward-facilitating effects. Acute intraperitoneal (i.p.) administration of LiCl (100, 200 mg/kg), VPA (400 mg/kg) or combined administration of subthreshold doses of LiCl (50 mg/kg) and VPA (200 mg/kg) increased ICSS thresholds. LiCl (100 mg/kg) and combined administration of LiCl and VPA (50 and 200 mg/kg), but not VPA alone (200, 400 mg/kg), attenuated d -amphetamine's reward-facilitating effects. These results suggest that ICSS combined with d -amphetamine constitutes a useful model to explore the elation and increased hedonistic drive observed in bipolar patients and ultimately help to identify novel pharmacotherapies for bipolar disorder.</description><subject>Analysis of Variance</subject><subject>Animal model</subject><subject>Animals</subject><subject>Antimanic Agents - administration & dosage</subject><subject>Behavior, Animal</subject><subject>Brain - drug effects</subject><subject>Brain - physiology</subject><subject>Brain stimulation reward</subject><subject>Central Nervous System Stimulants - administration & dosage</subject><subject>Conditioning, Operant - drug effects</subject><subject>d-Amphetamine</subject><subject>Dextroamphetamine - administration & dosage</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Routes</subject><subject>Drug Combinations</subject><subject>Internal Medicine</subject><subject>Lithium Chloride - administration & dosage</subject><subject>Male</subject><subject>Mood stabilizers</subject><subject>Psychiatry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reinforcement</subject><subject>Reward</subject><subject>Self Administration - methods</subject><subject>Valproic Acid - administration & dosage</subject><issn>0924-977X</issn><issn>1873-7862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk9rFTEUxYMo9ln9CpqVruaZm2SSjAuhlNoKBRdVcBcymTs1z_nzTDIt9dOb4T0UXIibBE7OuTfc3yXkFbAtMFBvd1tc4jytx5YzZrYAW8b4I7IBo0WljeKPyYY1XFaN1l9PyLOUdoxBLUTzlJxAA8AkExtyf9H36HOic0_Hee5oyq4NQ_iJsWgTbaMLE41472JH93H2mBImumoup3f0Ji9dKMKSwnRL8zcsTzk6H90U3EATDn2VchiXweVQ6u1ddF24HZ-TJ70bEr443qfky4eLz-dX1fWny4_nZ9eVlwZy1TLgWrVNLcB4bLwyrlWt5qikkJp5h5rV0DhWy9qDkd4LD9zUnXKt7OpWnJI3h7rl7z8WTNmOIXkcBjfhvCRrjGBSAIfifP1Pp1KmkUyZYtQHo49zShF7u49hdPHBArMrHbuzv-nYlY4FsIVOSb48tljaEbs_uSOOYjg7GLCM5C5gtMkHnDx2IRZKtpvDfzR5_1cNP4QpeDd8xwdMu3mJU5m4BZu4ZfZmXZJ1R5gpaW24-AUhNLwr</recordid><startdate>20090301</startdate><enddate>20090301</enddate><creator>Mavrikaki, Maria</creator><creator>Nomikos, George G</creator><creator>Panagis, George</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20090301</creationdate><title>Effects of mood stabilizers on brain reward processes in rats: Studies using the intracranial self-stimulation paradigm</title><author>Mavrikaki, Maria ; Nomikos, George G ; Panagis, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-b01276b95318ce9c68ab6b72e643470cae70519a0545c184cc3c1285d6ab4d5b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Analysis of Variance</topic><topic>Animal model</topic><topic>Animals</topic><topic>Antimanic Agents - administration & dosage</topic><topic>Behavior, Animal</topic><topic>Brain - drug effects</topic><topic>Brain - physiology</topic><topic>Brain stimulation reward</topic><topic>Central Nervous System Stimulants - administration & dosage</topic><topic>Conditioning, Operant - drug effects</topic><topic>d-Amphetamine</topic><topic>Dextroamphetamine - administration & dosage</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Routes</topic><topic>Drug Combinations</topic><topic>Internal Medicine</topic><topic>Lithium Chloride - administration & dosage</topic><topic>Male</topic><topic>Mood stabilizers</topic><topic>Psychiatry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reinforcement</topic><topic>Reward</topic><topic>Self Administration - methods</topic><topic>Valproic Acid - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mavrikaki, Maria</creatorcontrib><creatorcontrib>Nomikos, George G</creatorcontrib><creatorcontrib>Panagis, George</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>European neuropsychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mavrikaki, Maria</au><au>Nomikos, George G</au><au>Panagis, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of mood stabilizers on brain reward processes in rats: Studies using the intracranial self-stimulation paradigm</atitle><jtitle>European neuropsychopharmacology</jtitle><addtitle>Eur Neuropsychopharmacol</addtitle><date>2009-03-01</date><risdate>2009</risdate><volume>19</volume><issue>3</issue><spage>205</spage><epage>214</epage><pages>205-214</pages><issn>0924-977X</issn><eissn>1873-7862</eissn><abstract>Abstract Bipolar disorder is characterized by dysregulated motivation and increased hedonistic drive. d -Amphetamine induces manic symptoms in humans and exacerbates mania in bipolar disorder patients, effects that are counteracted by mood stabilizers. We utilized intracranial self-stimulation (ICSS) to examine how lithium (LiCl), valproate (VPA) or their combination that is commonly used in the clinic affect brain reward function in rats, and how these drugs affect d -amphetamine's reward-facilitating effects. Acute intraperitoneal (i.p.) administration of LiCl (100, 200 mg/kg), VPA (400 mg/kg) or combined administration of subthreshold doses of LiCl (50 mg/kg) and VPA (200 mg/kg) increased ICSS thresholds. LiCl (100 mg/kg) and combined administration of LiCl and VPA (50 and 200 mg/kg), but not VPA alone (200, 400 mg/kg), attenuated d -amphetamine's reward-facilitating effects. These results suggest that ICSS combined with d -amphetamine constitutes a useful model to explore the elation and increased hedonistic drive observed in bipolar patients and ultimately help to identify novel pharmacotherapies for bipolar disorder.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>19110403</pmid><doi>10.1016/j.euroneuro.2008.11.002</doi><tpages>10</tpages></addata></record> |
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| subjects | Analysis of Variance Animal model Animals Antimanic Agents - administration & dosage Behavior, Animal Brain - drug effects Brain - physiology Brain stimulation reward Central Nervous System Stimulants - administration & dosage Conditioning, Operant - drug effects d-Amphetamine Dextroamphetamine - administration & dosage Dose-Response Relationship, Drug Drug Administration Routes Drug Combinations Internal Medicine Lithium Chloride - administration & dosage Male Mood stabilizers Psychiatry Rats Rats, Sprague-Dawley Reinforcement Reward Self Administration - methods Valproic Acid - administration & dosage |
| title | Effects of mood stabilizers on brain reward processes in rats: Studies using the intracranial self-stimulation paradigm |
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