Modelling acute renal failure using blood and breath biomarkers in rats

Abstract This paper compares three methods for estimating renal function, as tested in rats. Acute renal failure (ARF) was induced via a 60-min bilateral renal artery clamp in 8 Sprague–Dawley rats and renal function was monitored for 1 week post-surgery. A two-compartment model was developed for es...

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Veröffentlicht in:	Computer methods and programs in biomedicine 2011-02, Vol.101 (2), p.173-182
Hauptverfasser:	Moorhead, Katherine T, Hill, Jonathan V, Chase, J. Geoffrey, Hann, Christopher E, Scotter, Jennifer M, Storer, Malina K, Endre, Zoltan H
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - physiopathology Animals Arteries Biomarkers - analysis Breath biomarkers Computer programs Correlation Differential equations Estimating Failure Glomerular Filtration Rate Integral fitting method Internal Medicine Mass Spectrometry Mathematical models Model-based approximation Models, Theoretical Other Rats Renal function Tracer kinetics
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