The utility of the minipig as an animal model in regulatory toxicology

In this article we review the value and utility of the minipig as an animal model in regulatory toxicity testing. Our review is based on detailed consideration of the comparative biology of the minipig, and of the practical features of toxicity testing in the minipig. The minipig presents a favourab...

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Veröffentlicht in:	Journal of pharmacological and toxicological methods 2010-11, Vol.62 (3), p.196-220
Hauptverfasser:	Bode, Gerd, Clausing, Peter, Gervais, Frederic, Loegsted, Jeanet, Luft, Jörg, Nogues, Vicente, Sims, Jennifer
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Use Alternatives Animals Animals, Laboratory - anatomy & histology Animals, Laboratory - embryology Animals, Laboratory - growth & development Animals, Laboratory - physiology Drug Industry - trends European Union Female Government Regulation Humans Male Methods Minipig Models, Animal Primates Research Design RETHINK Species Specificity Swine Swine, Miniature - anatomy & histology Swine, Miniature - embryology Swine, Miniature - growth & development Swine, Miniature - physiology Toxicity Tests - standards Toxicology Xenobiotics - pharmacokinetics Xenobiotics - toxicity
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