Variable behavior and complications of autologous bone marrow mesenchymal stem cells transplanted in experimental autoimmune encephalomyelitis

Autologous bone marrow stromal cells (BMSCs) offer significant practical advantages for potential clinical applications in multiple sclerosis (MS). Based on recent experimental data, a number of clinical trials have been designed for the intravenous (IV) and/or intrathecal (ITH) administration of BM...

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Veröffentlicht in:	Experimental neurology 2011-07, Vol.230 (1), p.78-89
Hauptverfasser:	Grigoriadis, Nikolaos, Lourbopoulos, Athanasios, Lagoudaki, Roza, Frischer, Josa-Maria, Polyzoidou, Eleni, Touloumi, Olga, Simeonidou, Constantina, Deretzi, Georgia, Kountouras, Jannis, Spandou, Evangelia, Kotta, Konstantia, Karkavelas, Georgios, Tascos, Nikolaos, Lassmann, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Adverse events Allografts Animals Area Under Curve Biological and medical sciences Bone marrow stromal cells Brain - pathology Cell Survival - drug effects Central Nervous System - metabolism Central Nervous System - pathology Collagen deposition Development. Senescence. Regeneration. Transplantation Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental - mortality Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - surgery Experimental autoimmune encephalomyelitis Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Green Fluorescent Proteins - genetics Injections, Intraventricular - adverse effects Interferon-gamma - metabolism Intraventricular Masses Medical sciences Mesenchymal Stem Cell Transplantation - adverse effects Mesenchymal stem cells Mesenchymal Stromal Cells - physiology Mice Mice, Inbred C57BL Mice, Transgenic Neural precursor cells Neural Stem Cells - physiology Neural Stem Cells - transplantation Neurology Severity of Illness Index Spinal Cord - pathology Transforming Growth Factor beta - metabolism Transplantation Transplantation, Autologous - adverse effects Tumor Necrosis Factor-alpha - metabolism Vertebrates: nervous system and sense organs
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