Tracer kinetic analysis of dynamic contrast-enhanced MRI and CT bladder cancer data: A preliminary comparison to assess the magnitude of water exchange effects

The purpose of this study was to determine the impact of water exchange on tracer kinetic parameter estimates derived from T1‐weighted dynamic contrast‐enhanced (DCE)‐MRI data using a direct quantitative comparison with DCE‐CT. Data were acquired from 12 patients with bladder cancer who underwent DC...

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Veröffentlicht in:Magnetic resonance in medicine 2010-08, Vol.64 (2), p.595-603
Hauptverfasser: Bains, Lauren J., McGrath, Deirdre M., Naish, Josephine H., Cheung, Susan, Watson, Yvonne, Taylor, M. Ben, Logue, John P., M. Parker, Geoffrey J., Waterton, John C., Buckley, David L.
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container_issue 2
container_start_page 595
container_title Magnetic resonance in medicine
container_volume 64
creator Bains, Lauren J.
McGrath, Deirdre M.
Naish, Josephine H.
Cheung, Susan
Watson, Yvonne
Taylor, M. Ben
Logue, John P.
M. Parker, Geoffrey J.
Waterton, John C.
Buckley, David L.
description The purpose of this study was to determine the impact of water exchange on tracer kinetic parameter estimates derived from T1‐weighted dynamic contrast‐enhanced (DCE)‐MRI data using a direct quantitative comparison with DCE‐CT. Data were acquired from 12 patients with bladder cancer who underwent DCE‐CT followed by DCE‐MRI within a week. A two‐compartment tracer kinetic model was fitted to the CT data, and two versions of the same model with modifications to account for the fast exchange and no exchange limits of water exchange were fitted to the MR data. The two‐compartment tracer kinetic model provided estimates of the fractional plasma volume (vp), the extravascular extracellular space fraction (ve), plasma perfusion (Fp), and the microvascular permeability surface area product. Our findings suggest that DCE‐CT is an appropriate reference for DCE‐MRI in bladder cancers as the only significant difference found between CT and MR parameter estimates were the no exchange limit estimates of vp (P = 0.002). These results suggest that although water exchange between the intracellular and extravascular‐extracellular space has a negligible effect on DCE‐MRI, vascular–extravascular‐extracellular space water exchange may be more important. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.
doi_str_mv 10.1002/mrm.22430
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Ben</au><au>Logue, John P.</au><au>M. Parker, Geoffrey J.</au><au>Waterton, John C.</au><au>Buckley, David L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tracer kinetic analysis of dynamic contrast-enhanced MRI and CT bladder cancer data: A preliminary comparison to assess the magnitude of water exchange effects</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2010-08</date><risdate>2010</risdate><volume>64</volume><issue>2</issue><spage>595</spage><epage>603</epage><pages>595-603</pages><issn>0740-3194</issn><issn>1522-2594</issn><eissn>1522-2594</eissn><abstract>The purpose of this study was to determine the impact of water exchange on tracer kinetic parameter estimates derived from T1‐weighted dynamic contrast‐enhanced (DCE)‐MRI data using a direct quantitative comparison with DCE‐CT. Data were acquired from 12 patients with bladder cancer who underwent DCE‐CT followed by DCE‐MRI within a week. 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Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20665802</pmid><doi>10.1002/mrm.22430</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
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subjects Aged
Aged, 80 and over
Bladder
Bladder cancer
Body Water - metabolism
Cancer
Data acquisition
Estimates
Exchanging
Gadolinium DTPA - pharmacokinetics
Humans
Kinetics
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Mathematical models
Metabolic Clearance Rate
Microvasculature
Middle Aged
Parameter estimation
Perfusion
perfusion CT
Permeability
Pilot Projects
T1-weighted MRI
Tomography, X-Ray Computed - methods
tracer kinetic modeling
Urinary Bladder Neoplasms - diagnosis
Urinary Bladder Neoplasms - metabolism
Water exchange
title Tracer kinetic analysis of dynamic contrast-enhanced MRI and CT bladder cancer data: A preliminary comparison to assess the magnitude of water exchange effects
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