Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats
We investigated the effects of silymarin and naringenin in counteracting arsenic-induced hepatic oxidative stress post exposure. Male wistar rats were chronically exposed to sodium arsenite for eight months followed by oral treatment with silymarin and naringenin (50 mg/kg each) for 15 consecutive d...
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| Veröffentlicht in: | Ecotoxicology and environmental safety 2011-05, Vol.74 (4), p.607-614 |
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| creator | Jain, Anshu Yadav, Abhishek Bozhkov, A.I. Padalko, V.I. Flora, S.J.S. |
| description | We investigated the effects of silymarin and naringenin in counteracting arsenic-induced hepatic oxidative stress post exposure. Male wistar rats were chronically exposed to sodium arsenite for eight months followed by oral treatment with silymarin and naringenin (50
mg/kg each) for 15 consecutive days to evaluate hepatic damage and antioxidant potential. Our results demonstrate a significant decrease in hepatic GSH levels, SOD and catalase activities and an increase in GST and TBARS levels after arsenic administration. Silymarin or naringenin administration increased GSH levels and was beneficial in the recovery of altered SOD and catalase activity besides significantly reducing blood and tissue arsenic concentration. Our results point to the antioxidant potential of these flavonoids, which might be of benefit in the clinical recovery of subject exposed to arsenic. These flavonoids can be incorporated into the diet or co-supplemented during chelation treatment, and thus may afford a protective effect against arsenite-induced cytotoxicity. |
| doi_str_mv | 10.1016/j.ecoenv.2010.08.002 |
| format | Article |
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mg/kg each) for 15 consecutive days to evaluate hepatic damage and antioxidant potential. Our results demonstrate a significant decrease in hepatic GSH levels, SOD and catalase activities and an increase in GST and TBARS levels after arsenic administration. Silymarin or naringenin administration increased GSH levels and was beneficial in the recovery of altered SOD and catalase activity besides significantly reducing blood and tissue arsenic concentration. Our results point to the antioxidant potential of these flavonoids, which might be of benefit in the clinical recovery of subject exposed to arsenic. These flavonoids can be incorporated into the diet or co-supplemented during chelation treatment, and thus may afford a protective effect against arsenite-induced cytotoxicity.</description><identifier>ISSN: 0147-6513</identifier><identifier>EISSN: 1090-2414</identifier><identifier>DOI: 10.1016/j.ecoenv.2010.08.002</identifier><identifier>PMID: 20719385</identifier><identifier>CODEN: EESADV</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Animal, plant and microbial ecology ; Animals ; antioxidant activity ; Antioxidants ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Applied ecology ; Arsenic ; Arsenic - metabolism ; Arsenic Poisoning - drug therapy ; Arsenic Poisoning - metabolism ; Arsenic toxicity ; Arsenites - toxicity ; Biological and medical sciences ; blood ; Catalase ; Catalase - metabolism ; Chelating Agents - therapeutic use ; Chelation ; Chemical and Drug Induced Liver Injury - drug therapy ; Chemical and Drug Induced Liver Injury - metabolism ; chronic exposure ; cytotoxicity ; Damage ; Ecotoxicology, biological effects of pollution ; Environmental Pollutants - metabolism ; Flavanones - pharmacology ; Flavanones - therapeutic use ; Flavonoids ; Fundamental and applied biological sciences. Psychology ; General aspects ; Glutathione - metabolism ; Glutathione Peroxidase - metabolism ; Glutathione Transferase - metabolism ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Liver - metabolism ; Male ; Naringenin ; oral administration ; Oxidative stress ; Oxidative Stress - drug effects ; protective effect ; Rat ; Rats ; Rats, Wistar ; Reactive Oxygen Species - metabolism ; Recovery ; Silymarin ; Silymarin - pharmacology ; Silymarin - therapeutic use ; Sod ; sodium arsenite ; Sodium Compounds - toxicity ; superoxide dismutase ; Superoxide Dismutase - metabolism ; Thiobarbituric Acid Reactive Substances - metabolism ; thiobarbituric acid-reactive substances ; Tissue arsenic concentration</subject><ispartof>Ecotoxicology and environmental safety, 2011-05, Vol.74 (4), p.607-614</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-86397a3b03ddc9100ea47c50817d2a1f96bbfe609cfd2cfa9ac02f24fa94b9f43</citedby><cites>FETCH-LOGICAL-c546t-86397a3b03ddc9100ea47c50817d2a1f96bbfe609cfd2cfa9ac02f24fa94b9f43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ecoenv.2010.08.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24219442$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20719385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jain, Anshu</creatorcontrib><creatorcontrib>Yadav, Abhishek</creatorcontrib><creatorcontrib>Bozhkov, A.I.</creatorcontrib><creatorcontrib>Padalko, V.I.</creatorcontrib><creatorcontrib>Flora, S.J.S.</creatorcontrib><title>Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats</title><title>Ecotoxicology and environmental safety</title><addtitle>Ecotoxicol Environ Saf</addtitle><description>We investigated the effects of silymarin and naringenin in counteracting arsenic-induced hepatic oxidative stress post exposure. Male wistar rats were chronically exposed to sodium arsenite for eight months followed by oral treatment with silymarin and naringenin (50
mg/kg each) for 15 consecutive days to evaluate hepatic damage and antioxidant potential. Our results demonstrate a significant decrease in hepatic GSH levels, SOD and catalase activities and an increase in GST and TBARS levels after arsenic administration. Silymarin or naringenin administration increased GSH levels and was beneficial in the recovery of altered SOD and catalase activity besides significantly reducing blood and tissue arsenic concentration. Our results point to the antioxidant potential of these flavonoids, which might be of benefit in the clinical recovery of subject exposed to arsenic. These flavonoids can be incorporated into the diet or co-supplemented during chelation treatment, and thus may afford a protective effect against arsenite-induced cytotoxicity.</description><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>antioxidant activity</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Antioxidants - therapeutic use</subject><subject>Applied ecology</subject><subject>Arsenic</subject><subject>Arsenic - metabolism</subject><subject>Arsenic Poisoning - drug therapy</subject><subject>Arsenic Poisoning - metabolism</subject><subject>Arsenic toxicity</subject><subject>Arsenites - toxicity</subject><subject>Biological and medical sciences</subject><subject>blood</subject><subject>Catalase</subject><subject>Catalase - metabolism</subject><subject>Chelating Agents - therapeutic use</subject><subject>Chelation</subject><subject>Chemical and Drug Induced Liver Injury - drug therapy</subject><subject>Chemical and Drug Induced Liver Injury - metabolism</subject><subject>chronic exposure</subject><subject>cytotoxicity</subject><subject>Damage</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Environmental Pollutants - metabolism</subject><subject>Flavanones - pharmacology</subject><subject>Flavanones - therapeutic use</subject><subject>Flavonoids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Transferase - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Naringenin</subject><subject>oral administration</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>protective effect</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Recovery</subject><subject>Silymarin</subject><subject>Silymarin - pharmacology</subject><subject>Silymarin - therapeutic use</subject><subject>Sod</subject><subject>sodium arsenite</subject><subject>Sodium Compounds - toxicity</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>thiobarbituric acid-reactive substances</subject><subject>Tissue arsenic concentration</subject><issn>0147-6513</issn><issn>1090-2414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd2L1DAQwIMo3nr6H4j2RfSl6-SrbV4O5PALDnzw7jlM08lelm67Ju3B_vemdNW3EwKZGX6ZSfJj7DWHLQdefdxvyY00PGwF5BI0WwDxhG04GCiF4uop2wBXdVlpLi_Yi5T2ACBB6-fsQkDNjWz0hoXbe4p4pHkKriDvg0N3KkZfpNCfDhjDUODQFcMS7WjIaV6RutnlvMCYcs2VYcgF6op7OuLSqMMD7mhBT-OcuYhTesmeeewTvTrvl-zuy-fb62_lzY-v368_3ZROq2oqm0qaGmULsuuc4QCEqnYaGl53Ark3Vdt6qsA43wnn0aAD4YXKkWqNV_KSvV_7HuP4a6Y02UNIjvoeBxrnZJtGguIyv_-_ZKUro7UWmfzwKMnruuZCSQ0ZVSvq4phSJG-PMeSPPFkOdhFn93YVZxdxFhqbxeVjb84T5vZA3d9Df0xl4N0ZwOSw9xEHF9I_TglulFoavV05j6PFXczM3c88SQFww2VVZ-JqJShbeAgUbXKBhuwvRHKT7cbw-F1_Ax2fwjI</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Jain, Anshu</creator><creator>Yadav, Abhishek</creator><creator>Bozhkov, A.I.</creator><creator>Padalko, V.I.</creator><creator>Flora, S.J.S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SU</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>KR7</scope><scope>7X8</scope><scope>7ST</scope><scope>7T2</scope><scope>7U2</scope><scope>7U7</scope><scope>SOI</scope></search><sort><creationdate>20110501</creationdate><title>Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats</title><author>Jain, Anshu ; Yadav, Abhishek ; Bozhkov, A.I. ; Padalko, V.I. ; Flora, S.J.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-86397a3b03ddc9100ea47c50817d2a1f96bbfe609cfd2cfa9ac02f24fa94b9f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>antioxidant activity</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Antioxidants - therapeutic use</topic><topic>Applied ecology</topic><topic>Arsenic</topic><topic>Arsenic - metabolism</topic><topic>Arsenic Poisoning - drug therapy</topic><topic>Arsenic Poisoning - metabolism</topic><topic>Arsenic toxicity</topic><topic>Arsenites - toxicity</topic><topic>Biological and medical sciences</topic><topic>blood</topic><topic>Catalase</topic><topic>Catalase - metabolism</topic><topic>Chelating Agents - therapeutic use</topic><topic>Chelation</topic><topic>Chemical and Drug Induced Liver Injury - drug therapy</topic><topic>Chemical and Drug Induced Liver Injury - metabolism</topic><topic>chronic exposure</topic><topic>cytotoxicity</topic><topic>Damage</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Environmental Pollutants - metabolism</topic><topic>Flavanones - pharmacology</topic><topic>Flavanones - therapeutic use</topic><topic>Flavonoids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Transferase - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Naringenin</topic><topic>oral administration</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>protective effect</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Recovery</topic><topic>Silymarin</topic><topic>Silymarin - pharmacology</topic><topic>Silymarin - therapeutic use</topic><topic>Sod</topic><topic>sodium arsenite</topic><topic>Sodium Compounds - toxicity</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>thiobarbituric acid-reactive substances</topic><topic>Tissue arsenic concentration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jain, Anshu</creatorcontrib><creatorcontrib>Yadav, Abhishek</creatorcontrib><creatorcontrib>Bozhkov, A.I.</creatorcontrib><creatorcontrib>Padalko, V.I.</creatorcontrib><creatorcontrib>Flora, S.J.S.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environmental Engineering Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environment Abstracts</collection><jtitle>Ecotoxicology and environmental safety</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jain, Anshu</au><au>Yadav, Abhishek</au><au>Bozhkov, A.I.</au><au>Padalko, V.I.</au><au>Flora, S.J.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats</atitle><jtitle>Ecotoxicology and environmental safety</jtitle><addtitle>Ecotoxicol Environ Saf</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>74</volume><issue>4</issue><spage>607</spage><epage>614</epage><pages>607-614</pages><issn>0147-6513</issn><eissn>1090-2414</eissn><coden>EESADV</coden><abstract>We investigated the effects of silymarin and naringenin in counteracting arsenic-induced hepatic oxidative stress post exposure. Male wistar rats were chronically exposed to sodium arsenite for eight months followed by oral treatment with silymarin and naringenin (50
mg/kg each) for 15 consecutive days to evaluate hepatic damage and antioxidant potential. Our results demonstrate a significant decrease in hepatic GSH levels, SOD and catalase activities and an increase in GST and TBARS levels after arsenic administration. Silymarin or naringenin administration increased GSH levels and was beneficial in the recovery of altered SOD and catalase activity besides significantly reducing blood and tissue arsenic concentration. Our results point to the antioxidant potential of these flavonoids, which might be of benefit in the clinical recovery of subject exposed to arsenic. These flavonoids can be incorporated into the diet or co-supplemented during chelation treatment, and thus may afford a protective effect against arsenite-induced cytotoxicity.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>20719385</pmid><doi>10.1016/j.ecoenv.2010.08.002</doi><tpages>8</tpages></addata></record> |
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| subjects | Animal, plant and microbial ecology Animals antioxidant activity Antioxidants Antioxidants - pharmacology Antioxidants - therapeutic use Applied ecology Arsenic Arsenic - metabolism Arsenic Poisoning - drug therapy Arsenic Poisoning - metabolism Arsenic toxicity Arsenites - toxicity Biological and medical sciences blood Catalase Catalase - metabolism Chelating Agents - therapeutic use Chelation Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism chronic exposure cytotoxicity Damage Ecotoxicology, biological effects of pollution Environmental Pollutants - metabolism Flavanones - pharmacology Flavanones - therapeutic use Flavonoids Fundamental and applied biological sciences. Psychology General aspects Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Transferase - metabolism Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Male Naringenin oral administration Oxidative stress Oxidative Stress - drug effects protective effect Rat Rats Rats, Wistar Reactive Oxygen Species - metabolism Recovery Silymarin Silymarin - pharmacology Silymarin - therapeutic use Sod sodium arsenite Sodium Compounds - toxicity superoxide dismutase Superoxide Dismutase - metabolism Thiobarbituric Acid Reactive Substances - metabolism thiobarbituric acid-reactive substances Tissue arsenic concentration |
| title | Therapeutic efficacy of silymarin and naringenin in reducing arsenic-induced hepatic damage in young rats |
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