Modulation of murine bone marrow-derived dendritic cells and B-cells by MCS-18 a natural product isolated from Helleborus purpurascens
Abstract MCS-18, a natural product isolated from Helleborus purpurascens has been shown to have several beneficial effects in inflammatory and autoimmune disorders. However, very little is known regarding the immuno-modulatory capacity of MCS-18 in respect to murine bone marrow-derived dendritic cel...
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| Veröffentlicht in: | Immunobiology (1979) 2008-01, Vol.213 (9), p.871-878 |
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| container_issue | 9 |
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| container_title | Immunobiology (1979) |
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| creator | Littmann, Leonie Rößner, Susanne Kerek, Franz Steinkasserer, Alexander Zinser, Elisabeth |
| description | Abstract MCS-18, a natural product isolated from Helleborus purpurascens has been shown to have several beneficial effects in inflammatory and autoimmune disorders. However, very little is known regarding the immuno-modulatory capacity of MCS-18 in respect to murine bone marrow-derived dendritic cells (BM-DC) and B-cells. Thus, in the present study we examined the effect of MCS-18 on murine BM-DC and B-cells. Interestingly MCS-18 inhibited the expression of important DC-specific molecules and lead to an impaired T-cell stimulation capacity. In addition, MCS-18 also reduced B-cell proliferation and immunoglobulin production. |
| doi_str_mv | 10.1016/j.imbio.2008.07.013 |
| format | Article |
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However, very little is known regarding the immuno-modulatory capacity of MCS-18 in respect to murine bone marrow-derived dendritic cells (BM-DC) and B-cells. Thus, in the present study we examined the effect of MCS-18 on murine BM-DC and B-cells. Interestingly MCS-18 inhibited the expression of important DC-specific molecules and lead to an impaired T-cell stimulation capacity. 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However, very little is known regarding the immuno-modulatory capacity of MCS-18 in respect to murine bone marrow-derived dendritic cells (BM-DC) and B-cells. Thus, in the present study we examined the effect of MCS-18 on murine BM-DC and B-cells. Interestingly MCS-18 inhibited the expression of important DC-specific molecules and lead to an impaired T-cell stimulation capacity. In addition, MCS-18 also reduced B-cell proliferation and immunoglobulin production.</description><subject>Advanced Basic Science</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>B-cells</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - metabolism</subject><subject>Biological Products - isolation & purification</subject><subject>Biological Products - pharmacology</subject><subject>Bone Marrow Cells - drug effects</subject><subject>Bone Marrow Cells - immunology</subject><subject>Cell Proliferation - drug effects</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - drug effects</subject><subject>Dendritic Cells - immunology</subject><subject>Dendritic Cells - metabolism</subject><subject>Helleborus</subject><subject>Helleborus - chemistry</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulin G - drug effects</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Immunoglobulin M - drug effects</subject><subject>Immunologic Factors - isolation & purification</subject><subject>Immunologic Factors - pharmacology</subject><subject>MCS-18</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Proliferation</subject><subject>T-Lymphocytes - drug effects</subject><subject>T-Lymphocytes - immunology</subject><subject>T-Lymphocytes - metabolism</subject><issn>0171-2985</issn><issn>1878-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2KFDEUhYMoTjv6BIJkpatqb-ovyUJhbNQRZnAxug75uQVpq5I2qRrpF_C5TdkNgguFkGTx3ZPccy4hzxlsGbD-9X7rJ-PjtgYQW-BbYM0DsmGCi6qpuXxINsA4q2opugvyJOc9AJM1F4_JBROy7htgG_LzNrpl1LOPgcaBTkvyAamJZZt0SvFH5TD5e3TUYXDJz95Si-OYqQ6OvqtOd3Okt7u7igmqadDzkvRID6ko25n6HIt-ERhSnOh14dHEtGR6WFJZOlsM-Sl5NOgx47PzeUm-fnj_ZXdd3Xz--Gl3dVPZtm3najAahWy5dLpltte67YzWHe-Mk7LTwiIMomt7A9xZ2XSGgdF9J3vdi3pt-ZK8OumW331fMM9q8nntQQeMS1ZCNNACF1DIl_8ke9lz3jarZHMCbYo5JxzUIfni3VExUGtQaq9-B6XWoBRwVYIqVS_O8ouZ0P2pOSdTgDcnAIsd9x6TytZjsOh8QjsrF_1_Hnj7V70dffBWj9_wiHkflxSK04qpXCtQd-usrKMCAgCkaJpf0Vu7rg</recordid><startdate>20080101</startdate><enddate>20080101</enddate><creator>Littmann, Leonie</creator><creator>Rößner, Susanne</creator><creator>Kerek, Franz</creator><creator>Steinkasserer, Alexander</creator><creator>Zinser, Elisabeth</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20080101</creationdate><title>Modulation of murine bone marrow-derived dendritic cells and B-cells by MCS-18 a natural product isolated from Helleborus purpurascens</title><author>Littmann, Leonie ; Rößner, Susanne ; Kerek, Franz ; Steinkasserer, Alexander ; Zinser, Elisabeth</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-fbae89479da41c6aa45baa575bd995a8ce0f8546b07dc935b10ba6596a6829263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Advanced Basic Science</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>B-cells</topic><topic>B-Lymphocytes - drug effects</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - metabolism</topic><topic>Biological Products - isolation & purification</topic><topic>Biological Products - pharmacology</topic><topic>Bone Marrow Cells - drug effects</topic><topic>Bone Marrow Cells - immunology</topic><topic>Cell Proliferation - drug effects</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - drug effects</topic><topic>Dendritic Cells - immunology</topic><topic>Dendritic Cells - metabolism</topic><topic>Helleborus</topic><topic>Helleborus - chemistry</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulin G - drug effects</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Immunoglobulin M - drug effects</topic><topic>Immunologic Factors - isolation & purification</topic><topic>Immunologic Factors - pharmacology</topic><topic>MCS-18</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Proliferation</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><topic>T-Lymphocytes - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Littmann, Leonie</creatorcontrib><creatorcontrib>Rößner, Susanne</creatorcontrib><creatorcontrib>Kerek, Franz</creatorcontrib><creatorcontrib>Steinkasserer, Alexander</creatorcontrib><creatorcontrib>Zinser, Elisabeth</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Immunobiology (1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Littmann, Leonie</au><au>Rößner, Susanne</au><au>Kerek, Franz</au><au>Steinkasserer, Alexander</au><au>Zinser, Elisabeth</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of murine bone marrow-derived dendritic cells and B-cells by MCS-18 a natural product isolated from Helleborus purpurascens</atitle><jtitle>Immunobiology (1979)</jtitle><addtitle>Immunobiology</addtitle><date>2008-01-01</date><risdate>2008</risdate><volume>213</volume><issue>9</issue><spage>871</spage><epage>878</epage><pages>871-878</pages><issn>0171-2985</issn><eissn>1878-3279</eissn><abstract>Abstract MCS-18, a natural product isolated from Helleborus purpurascens has been shown to have several beneficial effects in inflammatory and autoimmune disorders. However, very little is known regarding the immuno-modulatory capacity of MCS-18 in respect to murine bone marrow-derived dendritic cells (BM-DC) and B-cells. Thus, in the present study we examined the effect of MCS-18 on murine BM-DC and B-cells. Interestingly MCS-18 inhibited the expression of important DC-specific molecules and lead to an impaired T-cell stimulation capacity. In addition, MCS-18 also reduced B-cell proliferation and immunoglobulin production.</abstract><cop>Netherlands</cop><pub>Elsevier GmbH</pub><pmid>18926301</pmid><doi>10.1016/j.imbio.2008.07.013</doi><tpages>8</tpages></addata></record> |
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| subjects | Advanced Basic Science Allergy and Immunology Animals B-cells B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological Products - isolation & purification Biological Products - pharmacology Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Cell Proliferation - drug effects Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Helleborus Helleborus - chemistry Immunoglobulin G - biosynthesis Immunoglobulin G - drug effects Immunoglobulin M - biosynthesis Immunoglobulin M - drug effects Immunologic Factors - isolation & purification Immunologic Factors - pharmacology MCS-18 Mice Mice, Inbred BALB C Mice, Inbred C57BL Proliferation T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism |
| title | Modulation of murine bone marrow-derived dendritic cells and B-cells by MCS-18 a natural product isolated from Helleborus purpurascens |
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