Modulation of murine bone marrow-derived dendritic cells and B-cells by MCS-18 a natural product isolated from Helleborus purpurascens

Abstract MCS-18, a natural product isolated from Helleborus purpurascens has been shown to have several beneficial effects in inflammatory and autoimmune disorders. However, very little is known regarding the immuno-modulatory capacity of MCS-18 in respect to murine bone marrow-derived dendritic cel...

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Veröffentlicht in:	Immunobiology (1979) 2008-01, Vol.213 (9), p.871-878
Hauptverfasser:	Littmann, Leonie, Rößner, Susanne, Kerek, Franz, Steinkasserer, Alexander, Zinser, Elisabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Allergy and Immunology Animals B-cells B-Lymphocytes - drug effects B-Lymphocytes - immunology B-Lymphocytes - metabolism Biological Products - isolation & purification Biological Products - pharmacology Bone Marrow Cells - drug effects Bone Marrow Cells - immunology Cell Proliferation - drug effects Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Helleborus Helleborus - chemistry Immunoglobulin G - biosynthesis Immunoglobulin G - drug effects Immunoglobulin M - biosynthesis Immunoglobulin M - drug effects Immunologic Factors - isolation & purification Immunologic Factors - pharmacology MCS-18 Mice Mice, Inbred BALB C Mice, Inbred C57BL Proliferation T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism
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Zusammenfassung:	Abstract MCS-18, a natural product isolated from Helleborus purpurascens has been shown to have several beneficial effects in inflammatory and autoimmune disorders. However, very little is known regarding the immuno-modulatory capacity of MCS-18 in respect to murine bone marrow-derived dendritic cells (BM-DC) and B-cells. Thus, in the present study we examined the effect of MCS-18 on murine BM-DC and B-cells. Interestingly MCS-18 inhibited the expression of important DC-specific molecules and lead to an impaired T-cell stimulation capacity. In addition, MCS-18 also reduced B-cell proliferation and immunoglobulin production.
ISSN:	0171-2985 1878-3279
DOI:	10.1016/j.imbio.2008.07.013