The cortisol awakening response (CAR): Facts and future directions
In humans, the secretion of cortisol from the adrenal glands follows a diurnal cycle with a profound increase after awakening. This increase after awakening, a phenomenon termed the cortisol awakening response (CAR), appears to be a distinct feature of the hypothalamus–pituitary–adrenal (HPA) axis,...
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| Veröffentlicht in: | International journal of psychophysiology 2009-04, Vol.72 (1), p.67-73 |
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| container_title | International journal of psychophysiology |
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| creator | Fries, Eva Dettenborn, Lucia Kirschbaum, Clemens |
| description | In humans, the secretion of cortisol from the adrenal glands follows a diurnal cycle with a profound increase after awakening. This increase after awakening, a phenomenon termed the
cortisol awakening response (CAR), appears to be a distinct feature of the hypothalamus–pituitary–adrenal (HPA) axis, superimposing the circadian rhythmicity of cortisol secretion. Several studies point towards an important role of the hippocampus and, additionally, other brain structures (e. g. amygdala, prefrontal cortex, suprachiasmatic nucleus) in the regulation of the CAR. There is increasing knowledge that the CAR is influenced by a variety of factors such as gender, health status, and health behavior or stress perception. However, the exact function of the profound cortisol increase after awakening is still not clarified. We hypothesize that the anticipation of the upcoming day is of major relevance for the magnitude of the CAR. The present paper reviews the current knowledge on the neural regulation of the CAR and factors influencing this phenomenon and considerations are addressed concerning the exact function of the CAR. |
| doi_str_mv | 10.1016/j.ijpsycho.2008.03.014 |
| format | Article |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Anti-Inflammatory Agents Cortisol awakening response Hippocampus Humans Hydrocortisone - metabolism Hydrocortisone - pharmacology Hypothalamic–pituitary–adrenal axis Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - physiology Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - physiology Wakefulness - drug effects Wakefulness - physiology |
| title | The cortisol awakening response (CAR): Facts and future directions |
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