BODIPY-modified 2′-deoxyguanosine as a novel tool to detect DNA damages

BODIPY-modified 2′-deoxyguanosine was synthesized for use as a detection reagent for genotoxic compounds. BODIPY-FL is a well known fluorescence reagent whose fluorescent light emission diminishes near a guanine base by a photo-induced electron transfer process. We attached BODIPY-Fl to the 5′ posit...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-07, Vol.21 (14), p.4206-4209
Hauptverfasser:	Takamura-Enya, Takeji, Ishii, Ryoko
Format:	Artikel
Sprache:	eng
Schlagworte:	2′-Deoxygunosine Alkylating reagents Alkylation Biological and medical sciences BODIPY Boron Compounds - chemistry Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chemical mutagenesis Deoxyguanosine - chemistry Deoxyguanosine - pharmacology DNA DNA - chemistry DNA Damage electron transfer fluorescence Fluorescent Dyes - chemistry fluorescent lighting genotoxicity guanine Medical sciences Mutagen oxidation Oxidation-Reduction Oxidative damages singlet oxygen Singlet Oxygen - chemistry Singlet Oxygen - metabolism Toxicology Tumors Ultraviolet Rays
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