TLR2, TLR4 and TLR9 are differentially modulated in liver lethally injured from BALB/c and C57BL/6 mice during Trypanosoma cruzi acute infection

Toll-like receptor (TLR) family is crucial for microbial elimination and homeostasis, and has an important immunoregulatory role. In this study, we comparatively analyze innate immune response and tissular injury elicited in BALB/c and C57BL/6 (B6) mice during acute Trypanosoma cruzi infection. The...

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Veröffentlicht in:	Molecular immunology 2008-08, Vol.45 (13), p.3580-3588
Hauptverfasser:	Carrera-Silva, Eugenio Antonio, Carolina, Cano Roxana, Natalia, Guiñazu, Pilar, Aoki Maria, Andrea, Pellegrini, Gea, Susana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chagas Disease - genetics Chagas Disease - mortality Chagas Disease - parasitology Chagas Disease - pathology Female Gene Expression Regulation Heart - parasitology Hepatic injury Inflammation Inflammation Mediators - metabolism Liver - metabolism Liver - parasitology Liver - pathology Mice Mice, Inbred BALB C - genetics Mice, Inbred BALB C - metabolism Mice, Inbred BALB C - parasitology Mice, Inbred C57BL - genetics Mice, Inbred C57BL - metabolism Mice, Inbred C57BL - parasitology Myocardium - metabolism Myocardium - pathology Parasite infection Signal Transduction - genetics Spleen - metabolism Spleen - pathology Survival Analysis Toll-like receptor Toll-Like Receptor 2 - genetics Toll-Like Receptor 2 - metabolism Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-Like Receptor 9 - genetics Toll-Like Receptor 9 - metabolism Trypanosoma cruzi Trypanosoma cruzi - immunology
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