Ultrasound-Triggered Drug Release and Enhanced Anticancer Effect of Doxorubicin-Loaded Poly(D,L-Lactide-Co-Glycolide)-Methoxy-Poly(Ethylene Glycol) Nanodroplets

Abstract A novel ultrasound-responsive doxorubicin (DOX)–loaded nanoparticulate system was prepared in this study. The DOX-loaded polymeric micelles were first prepared using poly(D,L-lactide-co-glycolide)-methoxy-poly(ethylene glycol) (PLGA-mPEG) with a high encapsulation efficiency of 89.2%. After...

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Veröffentlicht in:	Ultrasound in medicine & biology 2011-08, Vol.37 (8), p.1252-1258
Hauptverfasser:	Du, Lina, Jin, Yiguang, Zhou, Wenying, Zhao, Jingyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Chemotherapy Doxorubicin Doxorubicin - pharmacology Drug Carriers - chemistry Drug Carriers - pharmacology Drug Delivery Systems Female Hydrogen-Ion Concentration Lactic Acid - chemistry Lactic Acid - pharmacology Medical sciences Mice Micelles Nanodroplets Nanoparticles Neoplasms, Experimental - drug therapy Perfluoropentane Pharmacology. Drug treatments PLGA-mPEG Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polyglycolic Acid - chemistry Polyglycolic Acid - pharmacology Radiology Ultrasonics - methods Ultrasound
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