Ultrasound-Triggered Drug Release and Enhanced Anticancer Effect of Doxorubicin-Loaded Poly(D,L-Lactide-Co-Glycolide)-Methoxy-Poly(Ethylene Glycol) Nanodroplets
Abstract A novel ultrasound-responsive doxorubicin (DOX)–loaded nanoparticulate system was prepared in this study. The DOX-loaded polymeric micelles were first prepared using poly(D,L-lactide-co-glycolide)-methoxy-poly(ethylene glycol) (PLGA-mPEG) with a high encapsulation efficiency of 89.2%. After...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2011-08, Vol.37 (8), p.1252-1258 |
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| creator | Du, Lina Jin, Yiguang Zhou, Wenying Zhao, Jingyu |
| description | Abstract A novel ultrasound-responsive doxorubicin (DOX)–loaded nanoparticulate system was prepared in this study. The DOX-loaded polymeric micelles were first prepared using poly(D,L-lactide-co-glycolide)-methoxy-poly(ethylene glycol) (PLGA-mPEG) with a high encapsulation efficiency of 89.2%. After filling with perfluoropentane (boiling point 29°C), the micelles were transformed into nanodroplets that were stable as a result of the PEG shell. The nanodroplets were transformed into nanobubbles at 37°C, and little drug was released if no ultrasound was exerted. Ultrasound-triggered drug release, with pH dependency, was shown. The DOX release percentage was 9.59% at pH 6.5 (also appeared in tumor) and only 2.22% at pH 7.4 after sonicating for 0.5 min at 37°C. The tumor inhibitory rate of Group III (DOX-loaded nanodroplets combined with ultrasound) was 84.3%, more than that of Group II (DOX-loaded nanodroplets), which was 60.4%. Moreover, the nanodroplets showed much lower toxicity than free drugs. The novel nanodroplets could be a promising anticancer drug delivery system. |
| doi_str_mv | 10.1016/j.ultrasmedbio.2011.05.012 |
| format | Article |
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The DOX-loaded polymeric micelles were first prepared using poly(D,L-lactide-co-glycolide)-methoxy-poly(ethylene glycol) (PLGA-mPEG) with a high encapsulation efficiency of 89.2%. After filling with perfluoropentane (boiling point 29°C), the micelles were transformed into nanodroplets that were stable as a result of the PEG shell. The nanodroplets were transformed into nanobubbles at 37°C, and little drug was released if no ultrasound was exerted. Ultrasound-triggered drug release, with pH dependency, was shown. The DOX release percentage was 9.59% at pH 6.5 (also appeared in tumor) and only 2.22% at pH 7.4 after sonicating for 0.5 min at 37°C. The tumor inhibitory rate of Group III (DOX-loaded nanodroplets combined with ultrasound) was 84.3%, more than that of Group II (DOX-loaded nanodroplets), which was 60.4%. Moreover, the nanodroplets showed much lower toxicity than free drugs. The novel nanodroplets could be a promising anticancer drug delivery system.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2011.05.012</identifier><identifier>PMID: 21683513</identifier><identifier>CODEN: USMBA3</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Chemotherapy ; Doxorubicin ; Doxorubicin - pharmacology ; Drug Carriers - chemistry ; Drug Carriers - pharmacology ; Drug Delivery Systems ; Female ; Hydrogen-Ion Concentration ; Lactic Acid - chemistry ; Lactic Acid - pharmacology ; Medical sciences ; Mice ; Micelles ; Nanodroplets ; Nanoparticles ; Neoplasms, Experimental - drug therapy ; Perfluoropentane ; Pharmacology. Drug treatments ; PLGA-mPEG ; Polyethylene Glycols - chemistry ; Polyethylene Glycols - pharmacology ; Polyglycolic Acid - chemistry ; Polyglycolic Acid - pharmacology ; Radiology ; Ultrasonics - methods ; Ultrasound</subject><ispartof>Ultrasound in medicine & biology, 2011-08, Vol.37 (8), p.1252-1258</ispartof><rights>World Federation for Ultrasound in Medicine & Biology</rights><rights>2011 World Federation for Ultrasound in Medicine & Biology</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-486893a2672cb8decc5a828512cbf390baef5496a6d49b7217e9f760365ea6a03</citedby><cites>FETCH-LOGICAL-c599t-486893a2672cb8decc5a828512cbf390baef5496a6d49b7217e9f760365ea6a03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultrasmedbio.2011.05.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24340275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21683513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Lina</creatorcontrib><creatorcontrib>Jin, Yiguang</creatorcontrib><creatorcontrib>Zhou, Wenying</creatorcontrib><creatorcontrib>Zhao, Jingyu</creatorcontrib><title>Ultrasound-Triggered Drug Release and Enhanced Anticancer Effect of Doxorubicin-Loaded Poly(D,L-Lactide-Co-Glycolide)-Methoxy-Poly(Ethylene Glycol) Nanodroplets</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>Abstract A novel ultrasound-responsive doxorubicin (DOX)–loaded nanoparticulate system was prepared in this study. The DOX-loaded polymeric micelles were first prepared using poly(D,L-lactide-co-glycolide)-methoxy-poly(ethylene glycol) (PLGA-mPEG) with a high encapsulation efficiency of 89.2%. After filling with perfluoropentane (boiling point 29°C), the micelles were transformed into nanodroplets that were stable as a result of the PEG shell. The nanodroplets were transformed into nanobubbles at 37°C, and little drug was released if no ultrasound was exerted. Ultrasound-triggered drug release, with pH dependency, was shown. The DOX release percentage was 9.59% at pH 6.5 (also appeared in tumor) and only 2.22% at pH 7.4 after sonicating for 0.5 min at 37°C. The tumor inhibitory rate of Group III (DOX-loaded nanodroplets combined with ultrasound) was 84.3%, more than that of Group II (DOX-loaded nanodroplets), which was 60.4%. Moreover, the nanodroplets showed much lower toxicity than free drugs. The novel nanodroplets could be a promising anticancer drug delivery system.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Doxorubicin</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacology</subject><subject>Drug Delivery Systems</subject><subject>Female</subject><subject>Hydrogen-Ion Concentration</subject><subject>Lactic Acid - chemistry</subject><subject>Lactic Acid - pharmacology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Micelles</subject><subject>Nanodroplets</subject><subject>Nanoparticles</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Perfluoropentane</subject><subject>Pharmacology. Drug treatments</subject><subject>PLGA-mPEG</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polyethylene Glycols - pharmacology</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Polyglycolic Acid - pharmacology</subject><subject>Radiology</subject><subject>Ultrasonics - methods</subject><subject>Ultrasound</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktuO0zAQQCMEYsvCL6AICcFKuPgSOzEPSKu2LEjlItiVeLNcZ9K668bFTtDmb_hUnG25iCee7NGcGVtzJsueEDwlmIiX22nvuqDjDuqV9VOKCZliPsWE3skmpColopJ8vZtNMMMEcUHlSfYgxi3GuBSsvJ-dUCIqxgmbZD-ublv5vq3RZbDrNQSo83no1_lncKAj5Lqt80W70a1JmfO2s2a8hnzRNGC63Df53N_40K-ssS1ael0n7pN3w_P5iyVaatPZGtDMows3GO9ScIbeQ7fxNwO6xRbdZnDQQn4AzvIPuvV18HsHXXyY3Wu0i_DoeJ5mV28Wl7O3aPnx4t3sfIkMl7JDRSUqyTQVJTWrqgZjuK5oxUkKGybxSkPDCym0qAu5KikpQTalwExw0EJjdpo9O_TdB_-th9ipnY0GnNMt-D6qqmKYScGLRL46kCb4GAM0ah_sTodBEaxGQWqr_hakRkEKc5UEpeLHx2f6VUr_Lv1lJAFPj4CORrsmpGHb-IcrWIFpyRM3P3CQhvLdQlDRWBgd2ZC0qNrb__vP63_aGGfbpNhdwwBx6_vQprEroiJVWH0ZV2rcKEIwppxL9hOjI8yI</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Du, Lina</creator><creator>Jin, Yiguang</creator><creator>Zhou, Wenying</creator><creator>Zhao, Jingyu</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110801</creationdate><title>Ultrasound-Triggered Drug Release and Enhanced Anticancer Effect of Doxorubicin-Loaded Poly(D,L-Lactide-Co-Glycolide)-Methoxy-Poly(Ethylene Glycol) Nanodroplets</title><author>Du, Lina ; Jin, Yiguang ; Zhou, Wenying ; Zhao, Jingyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c599t-486893a2672cb8decc5a828512cbf390baef5496a6d49b7217e9f760365ea6a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Doxorubicin</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - pharmacology</topic><topic>Drug Delivery Systems</topic><topic>Female</topic><topic>Hydrogen-Ion Concentration</topic><topic>Lactic Acid - chemistry</topic><topic>Lactic Acid - pharmacology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Micelles</topic><topic>Nanodroplets</topic><topic>Nanoparticles</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Perfluoropentane</topic><topic>Pharmacology. Drug treatments</topic><topic>PLGA-mPEG</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polyethylene Glycols - pharmacology</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Polyglycolic Acid - pharmacology</topic><topic>Radiology</topic><topic>Ultrasonics - methods</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Lina</creatorcontrib><creatorcontrib>Jin, Yiguang</creatorcontrib><creatorcontrib>Zhou, Wenying</creatorcontrib><creatorcontrib>Zhao, Jingyu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Lina</au><au>Jin, Yiguang</au><au>Zhou, Wenying</au><au>Zhao, Jingyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ultrasound-Triggered Drug Release and Enhanced Anticancer Effect of Doxorubicin-Loaded Poly(D,L-Lactide-Co-Glycolide)-Methoxy-Poly(Ethylene Glycol) Nanodroplets</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>37</volume><issue>8</issue><spage>1252</spage><epage>1258</epage><pages>1252-1258</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><coden>USMBA3</coden><abstract>Abstract A novel ultrasound-responsive doxorubicin (DOX)–loaded nanoparticulate system was prepared in this study. The DOX-loaded polymeric micelles were first prepared using poly(D,L-lactide-co-glycolide)-methoxy-poly(ethylene glycol) (PLGA-mPEG) with a high encapsulation efficiency of 89.2%. After filling with perfluoropentane (boiling point 29°C), the micelles were transformed into nanodroplets that were stable as a result of the PEG shell. The nanodroplets were transformed into nanobubbles at 37°C, and little drug was released if no ultrasound was exerted. Ultrasound-triggered drug release, with pH dependency, was shown. The DOX release percentage was 9.59% at pH 6.5 (also appeared in tumor) and only 2.22% at pH 7.4 after sonicating for 0.5 min at 37°C. The tumor inhibitory rate of Group III (DOX-loaded nanodroplets combined with ultrasound) was 84.3%, more than that of Group II (DOX-loaded nanodroplets), which was 60.4%. Moreover, the nanodroplets showed much lower toxicity than free drugs. The novel nanodroplets could be a promising anticancer drug delivery system.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21683513</pmid><doi>10.1016/j.ultrasmedbio.2011.05.012</doi><tpages>7</tpages></addata></record> |
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| ispartof | Ultrasound in medicine & biology, 2011-08, Vol.37 (8), p.1252-1258 |
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| subjects | Animals Antineoplastic agents Biological and medical sciences Chemotherapy Doxorubicin Doxorubicin - pharmacology Drug Carriers - chemistry Drug Carriers - pharmacology Drug Delivery Systems Female Hydrogen-Ion Concentration Lactic Acid - chemistry Lactic Acid - pharmacology Medical sciences Mice Micelles Nanodroplets Nanoparticles Neoplasms, Experimental - drug therapy Perfluoropentane Pharmacology. Drug treatments PLGA-mPEG Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacology Polyglycolic Acid - chemistry Polyglycolic Acid - pharmacology Radiology Ultrasonics - methods Ultrasound |
| title | Ultrasound-Triggered Drug Release and Enhanced Anticancer Effect of Doxorubicin-Loaded Poly(D,L-Lactide-Co-Glycolide)-Methoxy-Poly(Ethylene Glycol) Nanodroplets |
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