Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow
Summary The effects of oleuropein on the processes of osteoblastogenesis and adipogenesis in mesenchymal stem cells (MSCs) from human bone marrow have been studied. We report that oleuropein, a polyphenol abundant in olive tree products, reduces the expression of peroxisome proliferator-activated re...
Gespeichert in:
Veröffentlicht in: | Osteoporosis international 2011-02, Vol.22 (2), p.675-684 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 684 |
---|---|
container_issue | 2 |
container_start_page | 675 |
container_title | Osteoporosis international |
container_volume | 22 |
creator | Santiago-Mora, R Casado-Díaz, A De Castro, M. D Quesada-Gómez, J. M |
description | Summary The effects of oleuropein on the processes of osteoblastogenesis and adipogenesis in mesenchymal stem cells (MSCs) from human bone marrow have been studied. We report that oleuropein, a polyphenol abundant in olive tree products, reduces the expression of peroxisome proliferator-activated receptor gamma (PPARγ), inhibits adipocyte differentiation, and enhances differentiation into osteoblast. Introduction Age-related bone loss is associated with osteoblast insufficiency during continuous bone remodeling. It has been suggested that the formation of osteoblasts in bone marrow is closely associated with adipogenesis, and age-related changes in this relationship could be responsible for the progressive adiposity of bone marrow which occurs with osteoporosis. In addition, the consumption of oleuropein, a major polyphenol in olive leaves and olive oil, has been associated with a reduction in bone loss. Methods We have analyzed the effects of oleuropein--at concentrations between 10⁻⁶ and 10⁻⁴ M--on the processes of osteoblastogenesis and adipogenesis in MSCs from human bone marrow. Results The results show an increase in osteoblast differentiation and a decrease in adipocyte differentiation when there is oleuropein in the culture media. The gene expression of osteoblastogenesis markers, RUNXII, osterix, collagen type I, osteocalcin, or alkaline phosphatase (ALP), was higher in osteoblast-induced oleuropein-treated cells. Also, the ALP activity and extracellular matrix mineralization were higher when oleuropein was present in the media. Oleuropein in MSCs induced adipocytes to produce a decrease in the expression of the genes involved in adipogenesis, the PPARγ, lipoprotein lipase, or fatty acid-binding protein 4, and minor fat accumulation. Conclusion Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis. |
doi_str_mv | 10.1007/s00198-010-1270-x |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_883038757</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2236705121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c456t-f54976265c86ebc8ac211f0313be900c9d8e6737ce952146f0dbddcae7ba1143</originalsourceid><addsrcrecordid>eNqFkc9u1DAQxi0EosvCA3ABCwlxCoxjJ457Q1X5I1XqgSJxixx7vOsqay92Au0L8Nx4lS2VOMDJHs3v-zzjj5DnDN4yAPkuAzDVVcCgYrWE6uYBWTHBeVWrtnlIVqC4rJRg307Ik5yvoWiUko_JSQ1CNQqaFfl1OeKc4h59oBi2OhjMNOYJ4zDqPMUNBsw-Ux0s9WHrBz-Vwvr9XeeUTluk6ByaicZArS_XhGHyevKlLr7FbUcNjmOmFpP_gZa6FHd0iAHpTqcUfz4lj5weMz47nmty9eH86uxTdXH58fPZ-4vKiKadKtcIJdu6bUzX4mA6bWrGHHDGB1QARtkOW8mlQdXUTLQO7GCt0SgHzcrPrMmbxXaf4vcZ89TvfD5MpgPGOfddx4F3spH_JwVwoRS0hXz1F3kd5xTKFn3HpZCyKeiasAUyKeac0PX75Mvqtz2D_pBlv2TZw6EuWfY3RfPiaDwPO7R_FHfhFeD1EdDZ6NGlkp7P9xzvaiVUV7h64XJphQ2m-wn_9frLReR07PUmFeOvX2pgvICF4IL_Bg36wqw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>837477540</pqid></control><display><type>article</type><title>Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Santiago-Mora, R ; Casado-Díaz, A ; De Castro, M. D ; Quesada-Gómez, J. M</creator><creatorcontrib>Santiago-Mora, R ; Casado-Díaz, A ; De Castro, M. D ; Quesada-Gómez, J. M</creatorcontrib><description>Summary The effects of oleuropein on the processes of osteoblastogenesis and adipogenesis in mesenchymal stem cells (MSCs) from human bone marrow have been studied. We report that oleuropein, a polyphenol abundant in olive tree products, reduces the expression of peroxisome proliferator-activated receptor gamma (PPARγ), inhibits adipocyte differentiation, and enhances differentiation into osteoblast. Introduction Age-related bone loss is associated with osteoblast insufficiency during continuous bone remodeling. It has been suggested that the formation of osteoblasts in bone marrow is closely associated with adipogenesis, and age-related changes in this relationship could be responsible for the progressive adiposity of bone marrow which occurs with osteoporosis. In addition, the consumption of oleuropein, a major polyphenol in olive leaves and olive oil, has been associated with a reduction in bone loss. Methods We have analyzed the effects of oleuropein--at concentrations between 10⁻⁶ and 10⁻⁴ M--on the processes of osteoblastogenesis and adipogenesis in MSCs from human bone marrow. Results The results show an increase in osteoblast differentiation and a decrease in adipocyte differentiation when there is oleuropein in the culture media. The gene expression of osteoblastogenesis markers, RUNXII, osterix, collagen type I, osteocalcin, or alkaline phosphatase (ALP), was higher in osteoblast-induced oleuropein-treated cells. Also, the ALP activity and extracellular matrix mineralization were higher when oleuropein was present in the media. Oleuropein in MSCs induced adipocytes to produce a decrease in the expression of the genes involved in adipogenesis, the PPARγ, lipoprotein lipase, or fatty acid-binding protein 4, and minor fat accumulation. Conclusion Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis.</description><identifier>ISSN: 0937-941X</identifier><identifier>EISSN: 1433-2965</identifier><identifier>DOI: 10.1007/s00198-010-1270-x</identifier><identifier>PMID: 20495905</identifier><language>eng</language><publisher>London: London : Springer-Verlag</publisher><subject>Adipocytes - drug effects ; Adipogenesis - drug effects ; Antihypertensive Agents - pharmacology ; Biological and medical sciences ; Biomarkers - metabolism ; Bone marrow ; Bone Marrow - metabolism ; Diseases of the osteoarticular system ; Endocrinology ; Humans ; Iridoids ; lipogenesis ; Medical sciences ; Medicine ; Medicine & Public Health ; Mesenchymal stem cell ; Mesenchymal Stromal Cells - metabolism ; Olea ; oleuropein ; Olive oil ; Original Article ; Orthopedics ; Osteoblastogenesis ; Osteoblasts - drug effects ; Osteoclasts - drug effects ; Osteogenesis - drug effects ; Osteoporosis ; Osteoporosis. Osteomalacia. Paget disease ; Polyphenols ; PPAR gamma - antagonists & inhibitors ; Pyrans - pharmacology ; Rheumatology ; Stem cells</subject><ispartof>Osteoporosis international, 2011-02, Vol.22 (2), p.675-684</ispartof><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2010</rights><rights>2015 INIST-CNRS</rights><rights>International Osteoporosis Foundation and National Osteoporosis Foundation 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-f54976265c86ebc8ac211f0313be900c9d8e6737ce952146f0dbddcae7ba1143</citedby><cites>FETCH-LOGICAL-c456t-f54976265c86ebc8ac211f0313be900c9d8e6737ce952146f0dbddcae7ba1143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00198-010-1270-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00198-010-1270-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23829498$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20495905$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santiago-Mora, R</creatorcontrib><creatorcontrib>Casado-Díaz, A</creatorcontrib><creatorcontrib>De Castro, M. D</creatorcontrib><creatorcontrib>Quesada-Gómez, J. M</creatorcontrib><title>Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow</title><title>Osteoporosis international</title><addtitle>Osteoporos Int</addtitle><addtitle>Osteoporos Int</addtitle><description>Summary The effects of oleuropein on the processes of osteoblastogenesis and adipogenesis in mesenchymal stem cells (MSCs) from human bone marrow have been studied. We report that oleuropein, a polyphenol abundant in olive tree products, reduces the expression of peroxisome proliferator-activated receptor gamma (PPARγ), inhibits adipocyte differentiation, and enhances differentiation into osteoblast. Introduction Age-related bone loss is associated with osteoblast insufficiency during continuous bone remodeling. It has been suggested that the formation of osteoblasts in bone marrow is closely associated with adipogenesis, and age-related changes in this relationship could be responsible for the progressive adiposity of bone marrow which occurs with osteoporosis. In addition, the consumption of oleuropein, a major polyphenol in olive leaves and olive oil, has been associated with a reduction in bone loss. Methods We have analyzed the effects of oleuropein--at concentrations between 10⁻⁶ and 10⁻⁴ M--on the processes of osteoblastogenesis and adipogenesis in MSCs from human bone marrow. Results The results show an increase in osteoblast differentiation and a decrease in adipocyte differentiation when there is oleuropein in the culture media. The gene expression of osteoblastogenesis markers, RUNXII, osterix, collagen type I, osteocalcin, or alkaline phosphatase (ALP), was higher in osteoblast-induced oleuropein-treated cells. Also, the ALP activity and extracellular matrix mineralization were higher when oleuropein was present in the media. Oleuropein in MSCs induced adipocytes to produce a decrease in the expression of the genes involved in adipogenesis, the PPARγ, lipoprotein lipase, or fatty acid-binding protein 4, and minor fat accumulation. Conclusion Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis.</description><subject>Adipocytes - drug effects</subject><subject>Adipogenesis - drug effects</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Bone marrow</subject><subject>Bone Marrow - metabolism</subject><subject>Diseases of the osteoarticular system</subject><subject>Endocrinology</subject><subject>Humans</subject><subject>Iridoids</subject><subject>lipogenesis</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mesenchymal stem cell</subject><subject>Mesenchymal Stromal Cells - metabolism</subject><subject>Olea</subject><subject>oleuropein</subject><subject>Olive oil</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>Osteoblastogenesis</subject><subject>Osteoblasts - drug effects</subject><subject>Osteoclasts - drug effects</subject><subject>Osteogenesis - drug effects</subject><subject>Osteoporosis</subject><subject>Osteoporosis. Osteomalacia. Paget disease</subject><subject>Polyphenols</subject><subject>PPAR gamma - antagonists & inhibitors</subject><subject>Pyrans - pharmacology</subject><subject>Rheumatology</subject><subject>Stem cells</subject><issn>0937-941X</issn><issn>1433-2965</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkc9u1DAQxi0EosvCA3ABCwlxCoxjJ457Q1X5I1XqgSJxixx7vOsqay92Au0L8Nx4lS2VOMDJHs3v-zzjj5DnDN4yAPkuAzDVVcCgYrWE6uYBWTHBeVWrtnlIVqC4rJRg307Ik5yvoWiUko_JSQ1CNQqaFfl1OeKc4h59oBi2OhjMNOYJ4zDqPMUNBsw-Ux0s9WHrBz-Vwvr9XeeUTluk6ByaicZArS_XhGHyevKlLr7FbUcNjmOmFpP_gZa6FHd0iAHpTqcUfz4lj5weMz47nmty9eH86uxTdXH58fPZ-4vKiKadKtcIJdu6bUzX4mA6bWrGHHDGB1QARtkOW8mlQdXUTLQO7GCt0SgHzcrPrMmbxXaf4vcZ89TvfD5MpgPGOfddx4F3spH_JwVwoRS0hXz1F3kd5xTKFn3HpZCyKeiasAUyKeac0PX75Mvqtz2D_pBlv2TZw6EuWfY3RfPiaDwPO7R_FHfhFeD1EdDZ6NGlkp7P9xzvaiVUV7h64XJphQ2m-wn_9frLReR07PUmFeOvX2pgvICF4IL_Bg36wqw</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Santiago-Mora, R</creator><creator>Casado-Díaz, A</creator><creator>De Castro, M. D</creator><creator>Quesada-Gómez, J. M</creator><general>London : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20110201</creationdate><title>Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow</title><author>Santiago-Mora, R ; Casado-Díaz, A ; De Castro, M. D ; Quesada-Gómez, J. M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-f54976265c86ebc8ac211f0313be900c9d8e6737ce952146f0dbddcae7ba1143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipocytes - drug effects</topic><topic>Adipogenesis - drug effects</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Bone marrow</topic><topic>Bone Marrow - metabolism</topic><topic>Diseases of the osteoarticular system</topic><topic>Endocrinology</topic><topic>Humans</topic><topic>Iridoids</topic><topic>lipogenesis</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mesenchymal stem cell</topic><topic>Mesenchymal Stromal Cells - metabolism</topic><topic>Olea</topic><topic>oleuropein</topic><topic>Olive oil</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>Osteoblastogenesis</topic><topic>Osteoblasts - drug effects</topic><topic>Osteoclasts - drug effects</topic><topic>Osteogenesis - drug effects</topic><topic>Osteoporosis</topic><topic>Osteoporosis. Osteomalacia. Paget disease</topic><topic>Polyphenols</topic><topic>PPAR gamma - antagonists & inhibitors</topic><topic>Pyrans - pharmacology</topic><topic>Rheumatology</topic><topic>Stem cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Santiago-Mora, R</creatorcontrib><creatorcontrib>Casado-Díaz, A</creatorcontrib><creatorcontrib>De Castro, M. D</creatorcontrib><creatorcontrib>Quesada-Gómez, J. M</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Osteoporosis international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santiago-Mora, R</au><au>Casado-Díaz, A</au><au>De Castro, M. D</au><au>Quesada-Gómez, J. M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow</atitle><jtitle>Osteoporosis international</jtitle><stitle>Osteoporos Int</stitle><addtitle>Osteoporos Int</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>22</volume><issue>2</issue><spage>675</spage><epage>684</epage><pages>675-684</pages><issn>0937-941X</issn><eissn>1433-2965</eissn><abstract>Summary The effects of oleuropein on the processes of osteoblastogenesis and adipogenesis in mesenchymal stem cells (MSCs) from human bone marrow have been studied. We report that oleuropein, a polyphenol abundant in olive tree products, reduces the expression of peroxisome proliferator-activated receptor gamma (PPARγ), inhibits adipocyte differentiation, and enhances differentiation into osteoblast. Introduction Age-related bone loss is associated with osteoblast insufficiency during continuous bone remodeling. It has been suggested that the formation of osteoblasts in bone marrow is closely associated with adipogenesis, and age-related changes in this relationship could be responsible for the progressive adiposity of bone marrow which occurs with osteoporosis. In addition, the consumption of oleuropein, a major polyphenol in olive leaves and olive oil, has been associated with a reduction in bone loss. Methods We have analyzed the effects of oleuropein--at concentrations between 10⁻⁶ and 10⁻⁴ M--on the processes of osteoblastogenesis and adipogenesis in MSCs from human bone marrow. Results The results show an increase in osteoblast differentiation and a decrease in adipocyte differentiation when there is oleuropein in the culture media. The gene expression of osteoblastogenesis markers, RUNXII, osterix, collagen type I, osteocalcin, or alkaline phosphatase (ALP), was higher in osteoblast-induced oleuropein-treated cells. Also, the ALP activity and extracellular matrix mineralization were higher when oleuropein was present in the media. Oleuropein in MSCs induced adipocytes to produce a decrease in the expression of the genes involved in adipogenesis, the PPARγ, lipoprotein lipase, or fatty acid-binding protein 4, and minor fat accumulation. Conclusion Our data suggest that oleuropein, highly abundant in olive tree products included in the traditional Mediterranean diet, could prevent age-related bone loss and osteoporosis.</abstract><cop>London</cop><pub>London : Springer-Verlag</pub><pmid>20495905</pmid><doi>10.1007/s00198-010-1270-x</doi><tpages>10</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0937-941X |
ispartof | Osteoporosis international, 2011-02, Vol.22 (2), p.675-684 |
issn | 0937-941X 1433-2965 |
language | eng |
recordid | cdi_proquest_miscellaneous_883038757 |
source | MEDLINE; Springer Online Journals Complete |
subjects | Adipocytes - drug effects Adipogenesis - drug effects Antihypertensive Agents - pharmacology Biological and medical sciences Biomarkers - metabolism Bone marrow Bone Marrow - metabolism Diseases of the osteoarticular system Endocrinology Humans Iridoids lipogenesis Medical sciences Medicine Medicine & Public Health Mesenchymal stem cell Mesenchymal Stromal Cells - metabolism Olea oleuropein Olive oil Original Article Orthopedics Osteoblastogenesis Osteoblasts - drug effects Osteoclasts - drug effects Osteogenesis - drug effects Osteoporosis Osteoporosis. Osteomalacia. Paget disease Polyphenols PPAR gamma - antagonists & inhibitors Pyrans - pharmacology Rheumatology Stem cells |
title | Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T06%3A22%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Oleuropein%20enhances%20osteoblastogenesis%20and%20inhibits%20adipogenesis:%20the%20effect%20on%20differentiation%20in%20stem%20cells%20derived%20from%20bone%20marrow&rft.jtitle=Osteoporosis%20international&rft.au=Santiago-Mora,%20R&rft.date=2011-02-01&rft.volume=22&rft.issue=2&rft.spage=675&rft.epage=684&rft.pages=675-684&rft.issn=0937-941X&rft.eissn=1433-2965&rft_id=info:doi/10.1007/s00198-010-1270-x&rft_dat=%3Cproquest_cross%3E2236705121%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=837477540&rft_id=info:pmid/20495905&rfr_iscdi=true |