A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes
To investigate the nationwide prevalence of hepatitis E virus (HEV) infection and to characterize HEV genomes among Japanese wild boars ( Sus scrofa leucomystax ), 578 boars captured in 25 prefectures from 2003 to 2010 were studied. Anti-HEV IgG was detected in 8.1%, and HEV RNA in 3.3% of boars. Am...
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| Veröffentlicht in: | Archives of virology 2011-08, Vol.156 (8), p.1345-1358 |
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| creator | Sato, Yukihiro Sato, Hiroyuki Naka, Keisuke Furuya, Satoshi Tsukiji, Haruhisa Kitagawa, Koji Sonoda, Yoshihide Usui, Takanobu Sakamoto, Hirotsugu Yoshino, Sumi Shimizu, Yuko Takahashi, Masaharu Nagashima, Shigeo Jirintai Nishizawa, Tsutomu Okamoto, Hiroaki |
| description | To investigate the nationwide prevalence of hepatitis E virus (HEV) infection and to characterize HEV genomes among Japanese wild boars (
Sus scrofa leucomystax
), 578 boars captured in 25 prefectures from 2003 to 2010 were studied. Anti-HEV IgG was detected in 8.1%, and HEV RNA in 3.3% of boars. Among the 19 boar HEV isolates obtained from infected boars, 14 isolates (74%) were classified as genotype 3, 4 isolates (21%) as genotype 4, and the remaining isolate (wbJOY_06) was distantly related to all known HEV isolates of genotypes 1-4, differing by 18.4-25.0% and 18.0-24.3% within the 412-nucleotide sequence of ORF1 and ORF2, respectively. A genotype 4 boar HEV isolate (wbJGF_08-1) obtained herein shared 98.6% identity over the entire genome with a human HEV isolate obtained from a patient who developed acute hepatitis after consuming undercooked wild boar meat, suggesting that wild boars are also reservoirs for genotype 4 HEV in humans. |
| doi_str_mv | 10.1007/s00705-011-0988-x |
| format | Article |
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Sus scrofa leucomystax
), 578 boars captured in 25 prefectures from 2003 to 2010 were studied. Anti-HEV IgG was detected in 8.1%, and HEV RNA in 3.3% of boars. Among the 19 boar HEV isolates obtained from infected boars, 14 isolates (74%) were classified as genotype 3, 4 isolates (21%) as genotype 4, and the remaining isolate (wbJOY_06) was distantly related to all known HEV isolates of genotypes 1-4, differing by 18.4-25.0% and 18.0-24.3% within the 412-nucleotide sequence of ORF1 and ORF2, respectively. A genotype 4 boar HEV isolate (wbJGF_08-1) obtained herein shared 98.6% identity over the entire genome with a human HEV isolate obtained from a patient who developed acute hepatitis after consuming undercooked wild boar meat, suggesting that wild boars are also reservoirs for genotype 4 HEV in humans.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/s00705-011-0988-x</identifier><identifier>PMID: 21475985</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Animals ; Antibodies, Viral - blood ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Developing countries ; Disease Reservoirs - veterinary ; Fundamental and applied biological sciences. Psychology ; Genomes ; Genotype ; Genotype & phenotype ; Hepatitis ; Hepatitis E - epidemiology ; Hepatitis E - veterinary ; Hepatitis E - virology ; Hepatitis E virus ; Hepatitis E virus - classification ; Hepatitis E virus - genetics ; Hogs ; Human viral diseases ; Humans ; Infections ; Infectious Diseases ; Japan - epidemiology ; LDCs ; Liver ; Liver - virology ; Medical Microbiology ; Medical sciences ; Microbiology ; Miscellaneous ; Original Article ; Phylogeny ; Prevalence ; RNA, Viral - blood ; Sus scrofa ; Viral diseases ; Viral hepatitis ; Virology ; Viruses ; Zoonoses</subject><ispartof>Archives of virology, 2011-08, Vol.156 (8), p.1345-1358</ispartof><rights>Springer-Verlag 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-b3e2faa05dbd3e38870308e9aa25d9f4dfee9eabd6f6b7da04635f4651ccb62d3</citedby><cites>FETCH-LOGICAL-c498t-b3e2faa05dbd3e38870308e9aa25d9f4dfee9eabd6f6b7da04635f4651ccb62d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00705-011-0988-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00705-011-0988-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24404412$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21475985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, Yukihiro</creatorcontrib><creatorcontrib>Sato, Hiroyuki</creatorcontrib><creatorcontrib>Naka, Keisuke</creatorcontrib><creatorcontrib>Furuya, Satoshi</creatorcontrib><creatorcontrib>Tsukiji, Haruhisa</creatorcontrib><creatorcontrib>Kitagawa, Koji</creatorcontrib><creatorcontrib>Sonoda, Yoshihide</creatorcontrib><creatorcontrib>Usui, Takanobu</creatorcontrib><creatorcontrib>Sakamoto, Hirotsugu</creatorcontrib><creatorcontrib>Yoshino, Sumi</creatorcontrib><creatorcontrib>Shimizu, Yuko</creatorcontrib><creatorcontrib>Takahashi, Masaharu</creatorcontrib><creatorcontrib>Nagashima, Shigeo</creatorcontrib><creatorcontrib>Jirintai</creatorcontrib><creatorcontrib>Nishizawa, Tsutomu</creatorcontrib><creatorcontrib>Okamoto, Hiroaki</creatorcontrib><title>A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes</title><title>Archives of virology</title><addtitle>Arch Virol</addtitle><addtitle>Arch Virol</addtitle><description>To investigate the nationwide prevalence of hepatitis E virus (HEV) infection and to characterize HEV genomes among Japanese wild boars (
Sus scrofa leucomystax
), 578 boars captured in 25 prefectures from 2003 to 2010 were studied. Anti-HEV IgG was detected in 8.1%, and HEV RNA in 3.3% of boars. Among the 19 boar HEV isolates obtained from infected boars, 14 isolates (74%) were classified as genotype 3, 4 isolates (21%) as genotype 4, and the remaining isolate (wbJOY_06) was distantly related to all known HEV isolates of genotypes 1-4, differing by 18.4-25.0% and 18.0-24.3% within the 412-nucleotide sequence of ORF1 and ORF2, respectively. A genotype 4 boar HEV isolate (wbJGF_08-1) obtained herein shared 98.6% identity over the entire genome with a human HEV isolate obtained from a patient who developed acute hepatitis after consuming undercooked wild boar meat, suggesting that wild boars are also reservoirs for genotype 4 HEV in humans.</description><subject>Animals</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Developing countries</subject><subject>Disease Reservoirs - veterinary</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Hepatitis</subject><subject>Hepatitis E - epidemiology</subject><subject>Hepatitis E - veterinary</subject><subject>Hepatitis E - virology</subject><subject>Hepatitis E virus</subject><subject>Hepatitis E virus - classification</subject><subject>Hepatitis E virus - genetics</subject><subject>Hogs</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Japan - epidemiology</subject><subject>LDCs</subject><subject>Liver</subject><subject>Liver - virology</subject><subject>Medical Microbiology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Original Article</subject><subject>Phylogeny</subject><subject>Prevalence</subject><subject>RNA, Viral - blood</subject><subject>Sus scrofa</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Virology</subject><subject>Viruses</subject><subject>Zoonoses</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkc9u1DAQxi0EokvhAbggCwlRDgE7thOnt6ra_kGVuABXy7HHi6usE-yk7fI6fdE63YWVkJC4jD3j33z2-EPoNSUfKSH1p5QDEQWhtCCNlMXdE7SgnJWFrBv5FC0II7yQFZEH6EVK14TkAhPP0UFJeS0aKRbo_gQHPfo-3HoLOE3xBja4d_gHDLk8-oSX-MbHKeGji-X3D9gHB2bm8w7f-s7ittcxzdlnPehwjLNOGL3z5lF21poJnLtxGqP2Ic21FYR-3AyQMMM6WMwf4xQimH4V_C-we-QleuZ0l-DVbj1E386WX08viqsv55enJ1eF4Y0ci5ZB6bQmwraWAZOyzuNKaLQuhW0ctw6gAd3aylVtbTXhFROOV4Ia01alZYfo_VZ3iP3PCdKo1j4Z6DodoJ-SkjJ_n2SS_gdJKKuEIJl8-xd53U8x5DFUNonLmosqQ3QLmdinFMGpIfq1jhtFiZqdVlunVXZazU6ru9zzZic8tWuwfzp-W5uBdztAJ6M7F3UwPu05zgnntMxcueVSPgoriPsX_vv2B4tpwpg</recordid><startdate>20110801</startdate><enddate>20110801</enddate><creator>Sato, Yukihiro</creator><creator>Sato, Hiroyuki</creator><creator>Naka, Keisuke</creator><creator>Furuya, Satoshi</creator><creator>Tsukiji, Haruhisa</creator><creator>Kitagawa, Koji</creator><creator>Sonoda, Yoshihide</creator><creator>Usui, Takanobu</creator><creator>Sakamoto, Hirotsugu</creator><creator>Yoshino, Sumi</creator><creator>Shimizu, Yuko</creator><creator>Takahashi, Masaharu</creator><creator>Nagashima, Shigeo</creator><creator>Jirintai</creator><creator>Nishizawa, Tsutomu</creator><creator>Okamoto, Hiroaki</creator><general>Springer Vienna</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20110801</creationdate><title>A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes</title><author>Sato, Yukihiro ; Sato, Hiroyuki ; Naka, Keisuke ; Furuya, Satoshi ; Tsukiji, Haruhisa ; Kitagawa, Koji ; Sonoda, Yoshihide ; Usui, Takanobu ; Sakamoto, Hirotsugu ; Yoshino, Sumi ; Shimizu, Yuko ; Takahashi, Masaharu ; Nagashima, Shigeo ; Jirintai ; Nishizawa, Tsutomu ; Okamoto, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-b3e2faa05dbd3e38870308e9aa25d9f4dfee9eabd6f6b7da04635f4651ccb62d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Developing countries</topic><topic>Disease Reservoirs - veterinary</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Hepatitis</topic><topic>Hepatitis E - epidemiology</topic><topic>Hepatitis E - veterinary</topic><topic>Hepatitis E - virology</topic><topic>Hepatitis E virus</topic><topic>Hepatitis E virus - classification</topic><topic>Hepatitis E virus - genetics</topic><topic>Hogs</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious Diseases</topic><topic>Japan - epidemiology</topic><topic>LDCs</topic><topic>Liver</topic><topic>Liver - virology</topic><topic>Medical Microbiology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Original Article</topic><topic>Phylogeny</topic><topic>Prevalence</topic><topic>RNA, Viral - blood</topic><topic>Sus scrofa</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Virology</topic><topic>Viruses</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, Yukihiro</creatorcontrib><creatorcontrib>Sato, Hiroyuki</creatorcontrib><creatorcontrib>Naka, Keisuke</creatorcontrib><creatorcontrib>Furuya, Satoshi</creatorcontrib><creatorcontrib>Tsukiji, Haruhisa</creatorcontrib><creatorcontrib>Kitagawa, Koji</creatorcontrib><creatorcontrib>Sonoda, Yoshihide</creatorcontrib><creatorcontrib>Usui, Takanobu</creatorcontrib><creatorcontrib>Sakamoto, Hirotsugu</creatorcontrib><creatorcontrib>Yoshino, Sumi</creatorcontrib><creatorcontrib>Shimizu, Yuko</creatorcontrib><creatorcontrib>Takahashi, Masaharu</creatorcontrib><creatorcontrib>Nagashima, Shigeo</creatorcontrib><creatorcontrib>Jirintai</creatorcontrib><creatorcontrib>Nishizawa, Tsutomu</creatorcontrib><creatorcontrib>Okamoto, Hiroaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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Sus scrofa leucomystax
), 578 boars captured in 25 prefectures from 2003 to 2010 were studied. Anti-HEV IgG was detected in 8.1%, and HEV RNA in 3.3% of boars. Among the 19 boar HEV isolates obtained from infected boars, 14 isolates (74%) were classified as genotype 3, 4 isolates (21%) as genotype 4, and the remaining isolate (wbJOY_06) was distantly related to all known HEV isolates of genotypes 1-4, differing by 18.4-25.0% and 18.0-24.3% within the 412-nucleotide sequence of ORF1 and ORF2, respectively. A genotype 4 boar HEV isolate (wbJGF_08-1) obtained herein shared 98.6% identity over the entire genome with a human HEV isolate obtained from a patient who developed acute hepatitis after consuming undercooked wild boar meat, suggesting that wild boars are also reservoirs for genotype 4 HEV in humans.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>21475985</pmid><doi>10.1007/s00705-011-0988-x</doi><tpages>14</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Antibodies, Viral - blood Biological and medical sciences Biomedical and Life Sciences Biomedicine Developing countries Disease Reservoirs - veterinary Fundamental and applied biological sciences. Psychology Genomes Genotype Genotype & phenotype Hepatitis Hepatitis E - epidemiology Hepatitis E - veterinary Hepatitis E - virology Hepatitis E virus Hepatitis E virus - classification Hepatitis E virus - genetics Hogs Human viral diseases Humans Infections Infectious Diseases Japan - epidemiology LDCs Liver Liver - virology Medical Microbiology Medical sciences Microbiology Miscellaneous Original Article Phylogeny Prevalence RNA, Viral - blood Sus scrofa Viral diseases Viral hepatitis Virology Viruses Zoonoses |
| title | A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes |
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