Dorsal-ventral distinction of chronic stress-induced electrophysiological alterations in the rat medial prefrontal cortex
Abstract Chronic stress causes neuronal adaptation and maladaptation in the widespread brain regions including the prefrontal cortex (PFC) and limbic structures, resulting in cognitive and affective dysfunctions. In this study, we examined the impacts of chronic stress on functional interaction betw...
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| Veröffentlicht in: | Neuroscience 2011-06, Vol.183, p.108-120 |
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| creator | Lee, Y.A Poirier, P Otani, S Goto, Y |
| description | Abstract Chronic stress causes neuronal adaptation and maladaptation in the widespread brain regions including the prefrontal cortex (PFC) and limbic structures, resulting in cognitive and affective dysfunctions. In this study, we examined the impacts of chronic stress on functional interaction between the medial PFC and limbic structures in rats. In vivo electrophysiological recordings in rats exposed to chronic stress unveiled disturbance of correlated local field potential activity between the PFC and limbic structures as well as impairment of synaptic plasticity induction in the limbic-PFC pathways. However, these stress-induced alterations in limbic–PFC interaction were distinct along with the dorsal-ventral axis within the PFC, with greater stress vulnerability in the dorsal than the ventral PFC, such that alterations in the dorsal PFC became evident with much shorter duration of repeated stress exposure than those occurring in the ventral PFC. In agreement with the stress-induced alterations in limbic–PFC interaction, spike firing patterns of neurons in the dorsal and ventral PFC were also differently modulated by chronic stress. These results suggest that chronic stress produces heterogeneous cellular and neural network adaptation and maladaptation within the PFC that affect limbic information integration mechanisms. |
| doi_str_mv | 10.1016/j.neuroscience.2011.03.039 |
| format | Article |
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In this study, we examined the impacts of chronic stress on functional interaction between the medial PFC and limbic structures in rats. In vivo electrophysiological recordings in rats exposed to chronic stress unveiled disturbance of correlated local field potential activity between the PFC and limbic structures as well as impairment of synaptic plasticity induction in the limbic-PFC pathways. However, these stress-induced alterations in limbic–PFC interaction were distinct along with the dorsal-ventral axis within the PFC, with greater stress vulnerability in the dorsal than the ventral PFC, such that alterations in the dorsal PFC became evident with much shorter duration of repeated stress exposure than those occurring in the ventral PFC. In agreement with the stress-induced alterations in limbic–PFC interaction, spike firing patterns of neurons in the dorsal and ventral PFC were also differently modulated by chronic stress. These results suggest that chronic stress produces heterogeneous cellular and neural network adaptation and maladaptation within the PFC that affect limbic information integration mechanisms.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2011.03.039</identifier><identifier>PMID: 21440605</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Action Potentials - physiology ; Analysis of Variance ; Animals ; Biological and medical sciences ; Brain Waves - physiology ; Disease Models, Animal ; Electric Stimulation - methods ; Electrophysiological Phenomena - physiology ; electrophysiology ; Evoked Potentials - physiology ; Fundamental and applied biological sciences. Psychology ; limbic structures ; Long-Term Potentiation - physiology ; Male ; Neural Pathways - physiopathology ; Neurology ; prefrontal cortex ; Prefrontal Cortex - pathology ; Prefrontal Cortex - physiopathology ; Rats ; Rats, Sprague-Dawley ; stress ; Stress, Psychological - pathology ; synaptic plasticity ; Time Factors ; Vertebrates: nervous system and sense organs ; Wakefulness</subject><ispartof>Neuroscience, 2011-06, Vol.183, p.108-120</ispartof><rights>IBRO</rights><rights>2011 IBRO</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 IBRO. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c562t-e72ee32d0e34863cf8d39b615fd64563a70d670ec561db9f053fc07bdb573ce33</citedby><cites>FETCH-LOGICAL-c562t-e72ee32d0e34863cf8d39b615fd64563a70d670ec561db9f053fc07bdb573ce33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2011.03.039$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24182442$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21440605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Y.A</creatorcontrib><creatorcontrib>Poirier, P</creatorcontrib><creatorcontrib>Otani, S</creatorcontrib><creatorcontrib>Goto, Y</creatorcontrib><title>Dorsal-ventral distinction of chronic stress-induced electrophysiological alterations in the rat medial prefrontal cortex</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract Chronic stress causes neuronal adaptation and maladaptation in the widespread brain regions including the prefrontal cortex (PFC) and limbic structures, resulting in cognitive and affective dysfunctions. In this study, we examined the impacts of chronic stress on functional interaction between the medial PFC and limbic structures in rats. In vivo electrophysiological recordings in rats exposed to chronic stress unveiled disturbance of correlated local field potential activity between the PFC and limbic structures as well as impairment of synaptic plasticity induction in the limbic-PFC pathways. However, these stress-induced alterations in limbic–PFC interaction were distinct along with the dorsal-ventral axis within the PFC, with greater stress vulnerability in the dorsal than the ventral PFC, such that alterations in the dorsal PFC became evident with much shorter duration of repeated stress exposure than those occurring in the ventral PFC. In agreement with the stress-induced alterations in limbic–PFC interaction, spike firing patterns of neurons in the dorsal and ventral PFC were also differently modulated by chronic stress. These results suggest that chronic stress produces heterogeneous cellular and neural network adaptation and maladaptation within the PFC that affect limbic information integration mechanisms.</description><subject>Action Potentials - physiology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain Waves - physiology</subject><subject>Disease Models, Animal</subject><subject>Electric Stimulation - methods</subject><subject>Electrophysiological Phenomena - physiology</subject><subject>electrophysiology</subject><subject>Evoked Potentials - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>limbic structures</subject><subject>Long-Term Potentiation - physiology</subject><subject>Male</subject><subject>Neural Pathways - physiopathology</subject><subject>Neurology</subject><subject>prefrontal cortex</subject><subject>Prefrontal Cortex - pathology</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>stress</subject><subject>Stress, Psychological - pathology</subject><subject>synaptic plasticity</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Wakefulness</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktuKFDEQhoMo7rj6CtII4lWPlWP3eCHIridY8EK9Dumk2snYk4xJenHe3jQzHvBGQ0ES8lVV8v8h5AmFNQWqnu_WAecUs_UYLK4ZULoGXmNzh6xo3_G2k0LcJSvgoFohGbsgD3LeQR1S8PvkglEhQIFckeN1TNlM7S2GkszUOJ-LD7b4GJo4NnabYvC2ySVhzq0PbrboGpzQlhQP22P2cYpfvK2pZiqYzJKZGx-assWmbps9Ol9PDwnHWqvUpY2p4PeH5N5opoyPzvMl-fzm9aerd-3Nh7fvr17dtFYqVlrsGCJnDpCLXnE79o5vBkXl6JSQipsOnOoAK03dsBlB8tFCN7hBdtwi55fk2anuIcVvM-ai9z5bnCYTMM5Z9z0H3nO6-TeppNqApKqSL06krTbk-jJ9SH5v0lFT0ItHeqf_9EgvHmngNZY2j89t5qGK8yv1pykVeHoGTK7CjskE6_NvTtCeCcEqd33isMp36zHpczvnU_VHu-j_7z4v_ypjJx8WS7_iEfMuzilUgzTVmWnQH5dftXwqSgE4q2r8AI2mzoI</recordid><startdate>20110602</startdate><enddate>20110602</enddate><creator>Lee, Y.A</creator><creator>Poirier, P</creator><creator>Otani, S</creator><creator>Goto, Y</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20110602</creationdate><title>Dorsal-ventral distinction of chronic stress-induced electrophysiological alterations in the rat medial prefrontal cortex</title><author>Lee, Y.A ; Poirier, P ; Otani, S ; Goto, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c562t-e72ee32d0e34863cf8d39b615fd64563a70d670ec561db9f053fc07bdb573ce33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Action Potentials - physiology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain Waves - physiology</topic><topic>Disease Models, Animal</topic><topic>Electric Stimulation - methods</topic><topic>Electrophysiological Phenomena - physiology</topic><topic>electrophysiology</topic><topic>Evoked Potentials - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>limbic structures</topic><topic>Long-Term Potentiation - physiology</topic><topic>Male</topic><topic>Neural Pathways - physiopathology</topic><topic>Neurology</topic><topic>prefrontal cortex</topic><topic>Prefrontal Cortex - pathology</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>stress</topic><topic>Stress, Psychological - pathology</topic><topic>synaptic plasticity</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Wakefulness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Y.A</creatorcontrib><creatorcontrib>Poirier, P</creatorcontrib><creatorcontrib>Otani, S</creatorcontrib><creatorcontrib>Goto, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Y.A</au><au>Poirier, P</au><au>Otani, S</au><au>Goto, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dorsal-ventral distinction of chronic stress-induced electrophysiological alterations in the rat medial prefrontal cortex</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2011-06-02</date><risdate>2011</risdate><volume>183</volume><spage>108</spage><epage>120</epage><pages>108-120</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Abstract Chronic stress causes neuronal adaptation and maladaptation in the widespread brain regions including the prefrontal cortex (PFC) and limbic structures, resulting in cognitive and affective dysfunctions. In this study, we examined the impacts of chronic stress on functional interaction between the medial PFC and limbic structures in rats. In vivo electrophysiological recordings in rats exposed to chronic stress unveiled disturbance of correlated local field potential activity between the PFC and limbic structures as well as impairment of synaptic plasticity induction in the limbic-PFC pathways. However, these stress-induced alterations in limbic–PFC interaction were distinct along with the dorsal-ventral axis within the PFC, with greater stress vulnerability in the dorsal than the ventral PFC, such that alterations in the dorsal PFC became evident with much shorter duration of repeated stress exposure than those occurring in the ventral PFC. In agreement with the stress-induced alterations in limbic–PFC interaction, spike firing patterns of neurons in the dorsal and ventral PFC were also differently modulated by chronic stress. 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| subjects | Action Potentials - physiology Analysis of Variance Animals Biological and medical sciences Brain Waves - physiology Disease Models, Animal Electric Stimulation - methods Electrophysiological Phenomena - physiology electrophysiology Evoked Potentials - physiology Fundamental and applied biological sciences. Psychology limbic structures Long-Term Potentiation - physiology Male Neural Pathways - physiopathology Neurology prefrontal cortex Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Rats Rats, Sprague-Dawley stress Stress, Psychological - pathology synaptic plasticity Time Factors Vertebrates: nervous system and sense organs Wakefulness |
| title | Dorsal-ventral distinction of chronic stress-induced electrophysiological alterations in the rat medial prefrontal cortex |
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