The naturally occurring steroid solasodine induces neurogenesis in vitro and in vivo

Abstract In this study, we explored the capacity of the naturally occurring compound solasodine to promote neurogenesis in vitro and in vivo . Mouse embryonic teratocarcinoma P19 cells exposed to solasodine for 2 days followed by a 5-day washout differentiated into cholinergic neurons that expressed...

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Veröffentlicht in:	Neuroscience 2011-06, Vol.183, p.251-264
Hauptverfasser:	Lecanu, L, Hashim, A.I, McCourty, A, Giscos-Douriez, I, Dinca, I, Yao, W, Vicini, S, Szabo, G, Erdélyi, F, Greeson, J, Papadopoulos, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - cytology Brain - drug effects Bromodeoxyuridine - metabolism Carrier Proteins - metabolism Cell Differentiation - drug effects Cell Line Fundamental and applied biological sciences. Psychology GAP43 Gene Expression Regulation - drug effects Humans Male Mice Microtubule-Associated Proteins - metabolism Nerve Tissue Proteins - metabolism Neurites - drug effects neurogenesis Neurogenesis - drug effects Neurology Neurons - cytology Neurons - drug effects Neuropeptides - metabolism neurosteroids Protein Binding - drug effects Radioimmunoassay - methods Rats Rats, Long-Evans Receptors, GABA-A - metabolism Solanaceous Alkaloids - pharmacology solasodine Steroids - pharmacology subventricular zone Teratocarcinoma - pathology Time Factors TSPO Vertebrates: nervous system and sense organs
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