A molecular immunology approach to antibody humanization and functional optimization

We introduce a new method of humanization based on a novel and immunologically relevant metric of antibody humanness, termed human string content (HSC), that quantifies a sequence at the level of potential MHC/T-cell epitopes. Use of this quantity rather than global identity as an optimization goal...

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Veröffentlicht in:	Molecular immunology 2007-03, Vol.44 (8), p.1986-1998
Hauptverfasser:	Lazar, Greg A., Desjarlais, John R., Jacinto, Jonathan, Karki, Sher, Hammond, Philip W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animals Antibodies, Monoclonal - genetics Antibody Antibody Specificity - genetics Genes, Synthetic Humanization Humans Immunogenicity Immunoglobulin Variable Region - genetics Mice Protein Engineering String content
Online-Zugang:	Volltext
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