Effect of gold nanoparticles on glutathione depletion-induced hydrogen peroxide generation and apoptosis in HL7702 cells

► The mechanism for GSH depletion induced by gold nanoparticles in human liver cells (HL7702). ► Cytosolic and mitochondrial GSH depletion in HL7702 cells following 8 nm gold nanoparticles treatment. ► H 2O 2 generation increased significantly following the depletion of mitochondrial GSH. ► The sequ...

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Veröffentlicht in:	Toxicology letters 2011-08, Vol.205 (1), p.86-95
Hauptverfasser:	Gao, Wen, Xu, Kehua, Ji, Lifei, Tang, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Apoptosis - drug effects bcl-2-Associated X Protein - metabolism Biological and medical sciences Blotting, Western Caspase 3 - metabolism Cell Line, Tumor Chemical and industrial products toxicology. Toxic occupational diseases Cytochromes c - metabolism Cytosol - metabolism Enzyme Activation - drug effects Glutathione - deficiency Glutathione - metabolism Glutathione depletion Gold - toxicity Gold nanoparticles Humans Hydrogen Peroxide - metabolism Hydrogen peroxide generation Medical sciences Membrane Potentials - drug effects Metals and various inorganic compounds Microscopy, Electron, Transmission Mitochondria, Liver - drug effects Mitochondria, Liver - metabolism Mitochondrial Membranes - drug effects Nanoparticles - toxicity Particle Size Toxicology
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