Depletion of peripheral blood B cells with Rituximab and phenotype characterization of the recovering population in a patient with follicular lymphoma
Abstract The monoclonal antibody Rituximab is useful for treatment of patients with B-cell non-Hodgkin's lymphoma. We phenotypically analyzed reconstitution of peripheral B cells in a male patient with follicular lymphoma following their depletion with Rituximab. CD19+ and CD20+ B cell counts i...
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| Veröffentlicht in: | Leukemia research 2010-03, Vol.34 (3), p.307-311 |
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| container_title | Leukemia research |
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| creator | Abulayha, Abdulmunem M Tabal, Salah A Shawesh, Eman I Elbasir, Mohamed A Elbanani, Abdulrhman S Lamami, Yosra M Bredan, Amin |
| description | Abstract The monoclonal antibody Rituximab is useful for treatment of patients with B-cell non-Hodgkin's lymphoma. We phenotypically analyzed reconstitution of peripheral B cells in a male patient with follicular lymphoma following their depletion with Rituximab. CD19+ and CD20+ B cell counts in peripheral blood decreased rapidly following Rituximab treatment. Six months after the end of treatment, a few CD19+ B cells were detected in peripheral blood. These cells had a naive B cell phenotype (IgD+, CD27−) and they expressed high levels of CD38 and CD24, which show that the B cell pool was repopulated mainly with immature, naive B cells. |
| doi_str_mv | 10.1016/j.leukres.2009.06.005 |
| format | Article |
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We phenotypically analyzed reconstitution of peripheral B cells in a male patient with follicular lymphoma following their depletion with Rituximab. CD19+ and CD20+ B cell counts in peripheral blood decreased rapidly following Rituximab treatment. Six months after the end of treatment, a few CD19+ B cells were detected in peripheral blood. 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We phenotypically analyzed reconstitution of peripheral B cells in a male patient with follicular lymphoma following their depletion with Rituximab. CD19+ and CD20+ B cell counts in peripheral blood decreased rapidly following Rituximab treatment. Six months after the end of treatment, a few CD19+ B cells were detected in peripheral blood. These cells had a naive B cell phenotype (IgD+, CD27−) and they expressed high levels of CD38 and CD24, which show that the B cell pool was repopulated mainly with immature, naive B cells.</description><subject>Antibodies, Monoclonal - therapeutic use</subject><subject>Antibodies, Monoclonal, Murine-Derived</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>B cells</subject><subject>B-Lymphocyte Subsets - cytology</subject><subject>B-Lymphocyte Subsets - drug effects</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - drug effects</subject><subject>CD19</subject><subject>CD20</subject><subject>Cell Count</subject><subject>Cell Separation</subject><subject>Flow Cytometry</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Immunophenotyping</subject><subject>Lymphoma, Follicular - blood</subject><subject>Lymphoma, Follicular - drug therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phenotype</subject><subject>Recovery</subject><subject>Rituximab</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt2O1SAUhYnROMejj6DhzqtWKIXCjUbH32QSE3-uCaW7ljOcUqEdPT6IzytNjzHxZq4g7G-vHdbaCD2mpKSEimeH0sNyHSGVFSGqJKIkhN9BOyobVnDJ-F20I7TmRUUrcYEepHQgmVBU3UcXVHFJlJI79Ps1TB5mF0YcejxBdNMA0Xjc-hA6_Apb8D7hH24e8Cc3Lz_d0bTYjB3O3Bjm0wTYDiYaO-feX-av0jwAjmDDTX4dv-EpTIvfim7EBk_5DuO86fbBe2dzPWJ_Ok5DOJqH6F5vfIJH53OPvr598-XyfXH18d2Hy5dXha05nQvVC25tr1gLtaRV01ugVNiKt6ojjey5aBuATpC2M6qitSKi5owypXpQVki2R0833SmG7wukWR9dWr9sRghL0lIywoSU9a1kwxiXosrye8Q30saQUoReTzG7Fk-aEr1mpw_6nJ1es9NE6JxM7ntynrC0R-j-dZ3DysCLDYDsyI2DqJPNLlroXLZ61l1wt454_p-C9W501vhrOEE6hCWO2W5Ndao00Z_XBVr3hyhCKlkx9gcrI8XY</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Abulayha, Abdulmunem M</creator><creator>Tabal, Salah A</creator><creator>Shawesh, Eman I</creator><creator>Elbasir, Mohamed A</creator><creator>Elbanani, Abdulrhman S</creator><creator>Lamami, Yosra M</creator><creator>Bredan, Amin</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100301</creationdate><title>Depletion of peripheral blood B cells with Rituximab and phenotype characterization of the recovering population in a patient with follicular lymphoma</title><author>Abulayha, Abdulmunem M ; 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We phenotypically analyzed reconstitution of peripheral B cells in a male patient with follicular lymphoma following their depletion with Rituximab. CD19+ and CD20+ B cell counts in peripheral blood decreased rapidly following Rituximab treatment. Six months after the end of treatment, a few CD19+ B cells were detected in peripheral blood. These cells had a naive B cell phenotype (IgD+, CD27−) and they expressed high levels of CD38 and CD24, which show that the B cell pool was repopulated mainly with immature, naive B cells.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19580998</pmid><doi>10.1016/j.leukres.2009.06.005</doi><tpages>5</tpages></addata></record> |
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| ispartof | Leukemia research, 2010-03, Vol.34 (3), p.307-311 |
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| language | eng |
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| subjects | Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived Antineoplastic Agents - therapeutic use B cells B-Lymphocyte Subsets - cytology B-Lymphocyte Subsets - drug effects B-Lymphocytes - cytology B-Lymphocytes - drug effects CD19 CD20 Cell Count Cell Separation Flow Cytometry Hematology, Oncology and Palliative Medicine Humans Immunophenotyping Lymphoma, Follicular - blood Lymphoma, Follicular - drug therapy Male Middle Aged Phenotype Recovery Rituximab |
| title | Depletion of peripheral blood B cells with Rituximab and phenotype characterization of the recovering population in a patient with follicular lymphoma |
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