Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen

Abstract Background Recently, a highly specific serum autoantibody was discovered in patients with neuromyelitis optica, called NMO-IgG, and aquaporin-4, the most abundant water channel in the CNS, was identified as the target antigen. Several assays for the detection of NMO-IgG/AQP4-Ab have been de...

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Veröffentlicht in:	Journal of the neurological sciences 2010-04, Vol.291 (1), p.52-56
Hauptverfasser:	Jarius, S, Probst, C, Borowski, K, Franciotta, D, Wildemann, B, Stoecker, W, Wandinger, K.P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Animals Antibody to aquaporin-4 Aquaporin 4 - immunology Autoantibodies - blood Biological and medical sciences Cell Line Diagnosis Female Fluorescent Antibody Technique - methods Humans Immunofluorescence assay Immunohistochemistry - methods Longitudinally extensive transverse myelitis Male Medical sciences Mice Middle Aged Multiple sclerosis Myelitis, Transverse - blood Myelitis, Transverse - immunology Nephrology. Urinary tract diseases Neurology Neuromyelitis optica (Devic syndrome) Neuromyelitis Optica - blood Neuromyelitis Optica - immunology NMO-IgG Optic neuritis Optic Neuritis - blood Optic Neuritis - immunology Recombinant antigen Recombinant Proteins - immunology Reproducibility of Results Sensitivity and Specificity Tumors of the urinary system Urinary tract. Prostate gland Young Adult
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