Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York State anglers
Experimental literature suggests that polychlorinated biphenyls (PCBs) alter thyroid function however studies of non-occupational or acute exposures in human populations have presented equivocal results. This study considered associations between PCBs and thyroid function biomarkers in a specially s...
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| Veröffentlicht in: | International journal of hygiene and environmental health 2009-11, Vol.212 (6), p.599-611 |
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| creator | Bloom, Michael S. Vena, John E. Olson, James R. Kostyniak, Paul J. |
| description | Experimental literature suggests that polychlorinated biphenyls (PCBs) alter thyroid function however studies of non-occupational or acute exposures in human populations have presented equivocal results. This study considered associations between PCBs and thyroid function biomarkers in a specially selected subsample of participants from the New York State Angler Cohort Study, with the goal of hypotheses generation. Between 1995 and 1997, 38 subjects donated a blood specimen and completed a questionnaire. Sera were analyzed for 77 PCB congeners, β-HCH, DDE, HCB, mirex, oxychlordane, and trans-nonachlor using GC-ECD, as well as for lipids components, thyroid stimulating hormone (TSH) and free thyroxine (FT
4).
A priori, the sum of all 77 measured PCB congeners, 27 individual PCB congeners with literature evidence for thyroid effects, their sum, DDE, and HCB were chosen as potential predictors for thyroid function. Age, body mass index, cigarette smoking, gender, and use of thyroid relevant medications were considered as important covariates. Adjusted for log total serum lipids, significant (P |
| doi_str_mv | 10.1016/j.ijheh.2009.04.005 |
| format | Article |
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4).
A priori, the sum of all 77 measured PCB congeners, 27 individual PCB congeners with literature evidence for thyroid effects, their sum, DDE, and HCB were chosen as potential predictors for thyroid function. Age, body mass index, cigarette smoking, gender, and use of thyroid relevant medications were considered as important covariates. Adjusted for log total serum lipids, significant (P<0.05) bivariate correlations were demonstrated for log PCB IUPAC #s 153 (r=0.33), 170 (r=0.38), 171+156 (r=0.36), and 180 (r=0.35) with FT
4; however none were observed for log TSH. Using a forward stepwise selection procedure and confounder evaluation algorithm, log PCB #170 was a significant positive predictor of serum FT
4 (β=1.55 95%CI 0.04-3.07), adjusted for mean centered log PCB #187 and log serum total lipids. This association may be explained by competitive binding to serum thyroid binding proteins by PCB #170, its hydroxylated metabolite 4′-OH-PCB172, or other related but unconsidered compounds. However, bias due to the use of a competitive analog assay for free hormone measurement, random error, or uncontrolled confounding cannot be excluded. The results of this study suggest that Lake Ontario sportfish consumers may comprise a high risk population for PCB related thyroid function alteration and warrant a larger confirmatory investigation.</description><identifier>ISSN: 1438-4639</identifier><identifier>EISSN: 1618-131X</identifier><identifier>DOI: 10.1016/j.ijheh.2009.04.005</identifier><identifier>PMID: 19493696</identifier><language>eng</language><publisher>München: Elsevier GmbH</publisher><subject>Adult ; Air. Soil. Water. Waste. Feeding ; Biological and medical sciences ; Cohort Studies ; Cross-Sectional Studies ; Dichlorodiphenyldichloroethylene (DDE) ; Environment. Living conditions ; Female ; Fisheries ; Free thyroxine (FT 4) ; Hexachlorobenzene (HCB) ; Humans ; Male ; Medical sciences ; Miscellaneous ; New York ; Occupational Exposure - analysis ; Polychlorinated biphenyl (PCB) ; Polychlorinated Biphenyls - blood ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk Assessment ; Thyroid ; Thyroid stimulating hormone (TSH) ; Thyrotropin - blood ; Thyroxine - blood ; Toxicology</subject><ispartof>International journal of hygiene and environmental health, 2009-11, Vol.212 (6), p.599-611</ispartof><rights>2009 Elsevier GmbH</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-d7be97a50d8e991f4619803a0756953b910e6ffae56c5b0adbbe4c73fbd8095f3</citedby><cites>FETCH-LOGICAL-c420t-d7be97a50d8e991f4619803a0756953b910e6ffae56c5b0adbbe4c73fbd8095f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijheh.2009.04.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22148141$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19493696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bloom, Michael S.</creatorcontrib><creatorcontrib>Vena, John E.</creatorcontrib><creatorcontrib>Olson, James R.</creatorcontrib><creatorcontrib>Kostyniak, Paul J.</creatorcontrib><title>Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York State anglers</title><title>International journal of hygiene and environmental health</title><addtitle>Int J Hyg Environ Health</addtitle><description>Experimental literature suggests that polychlorinated biphenyls (PCBs) alter thyroid function however studies of non-occupational or acute exposures in human populations have presented equivocal results. This study considered associations between PCBs and thyroid function biomarkers in a specially selected subsample of participants from the New York State Angler Cohort Study, with the goal of hypotheses generation. Between 1995 and 1997, 38 subjects donated a blood specimen and completed a questionnaire. Sera were analyzed for 77 PCB congeners, β-HCH, DDE, HCB, mirex, oxychlordane, and trans-nonachlor using GC-ECD, as well as for lipids components, thyroid stimulating hormone (TSH) and free thyroxine (FT
4).
A priori, the sum of all 77 measured PCB congeners, 27 individual PCB congeners with literature evidence for thyroid effects, their sum, DDE, and HCB were chosen as potential predictors for thyroid function. Age, body mass index, cigarette smoking, gender, and use of thyroid relevant medications were considered as important covariates. Adjusted for log total serum lipids, significant (P<0.05) bivariate correlations were demonstrated for log PCB IUPAC #s 153 (r=0.33), 170 (r=0.38), 171+156 (r=0.36), and 180 (r=0.35) with FT
4; however none were observed for log TSH. Using a forward stepwise selection procedure and confounder evaluation algorithm, log PCB #170 was a significant positive predictor of serum FT
4 (β=1.55 95%CI 0.04-3.07), adjusted for mean centered log PCB #187 and log serum total lipids. This association may be explained by competitive binding to serum thyroid binding proteins by PCB #170, its hydroxylated metabolite 4′-OH-PCB172, or other related but unconsidered compounds. However, bias due to the use of a competitive analog assay for free hormone measurement, random error, or uncontrolled confounding cannot be excluded. The results of this study suggest that Lake Ontario sportfish consumers may comprise a high risk population for PCB related thyroid function alteration and warrant a larger confirmatory investigation.</description><subject>Adult</subject><subject>Air. Soil. Water. Waste. Feeding</subject><subject>Biological and medical sciences</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Dichlorodiphenyldichloroethylene (DDE)</subject><subject>Environment. Living conditions</subject><subject>Female</subject><subject>Fisheries</subject><subject>Free thyroxine (FT 4)</subject><subject>Hexachlorobenzene (HCB)</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>New York</subject><subject>Occupational Exposure - analysis</subject><subject>Polychlorinated biphenyl (PCB)</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk Assessment</subject><subject>Thyroid</subject><subject>Thyroid stimulating hormone (TSH)</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Toxicology</subject><issn>1438-4639</issn><issn>1618-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT2P1DAQhiME4o6DX4CE3CCayzKOHScuKE4nvqQTFIAEleXY442XxN6zs8A2_Ha87Ao6qDySn3lnNE9VPaawokDF883Kb0YcVw2AXAFfAbR3qnMqaF9TRj_fLTVnfc0Fk2fVg5w3AA2FXt6vzqjkkgkpzqufVzljzjOGhURHtnHam3GKyQe9oCWD344Y9hMxMawxYMqXZBn3KXpL8uLn3aQXH9ZkjGmOAS-JDpa4hHikfviARJefNXmH38mXmL6SD0tJLtx6KmkPq3tOTxkfnd6L6tOrlx-v39Q371-_vb66qQ1vYKltN6DsdAu2Rymp44LKHpiGrhWyZYOkgMI5ja0w7QDaDgNy0zE32B5k69hF9eyYu03xdod5UbPPBqdJB4y7rPqeARO0XOV_ZMc4bSRraSHZkTQp5pzQqW3ys057RUEdDKmN-m1IHQwp4KoYKl1PTvm7YUb7t-ekpABPT4DORk8u6WB8_sM1DeU95YfxL44clrt985hUNh6DQesTmkXZ6P-5yC--MrKK</recordid><startdate>20091101</startdate><enddate>20091101</enddate><creator>Bloom, Michael S.</creator><creator>Vena, John E.</creator><creator>Olson, James R.</creator><creator>Kostyniak, Paul J.</creator><general>Elsevier GmbH</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QH</scope><scope>7ST</scope><scope>7T2</scope><scope>7TV</scope><scope>7U1</scope><scope>7U2</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>L.G</scope><scope>SOI</scope></search><sort><creationdate>20091101</creationdate><title>Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York State anglers</title><author>Bloom, Michael S. ; Vena, John E. ; Olson, James R. ; Kostyniak, Paul J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-d7be97a50d8e991f4619803a0756953b910e6ffae56c5b0adbbe4c73fbd8095f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Air. Soil. Water. Waste. Feeding</topic><topic>Biological and medical sciences</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Dichlorodiphenyldichloroethylene (DDE)</topic><topic>Environment. Living conditions</topic><topic>Female</topic><topic>Fisheries</topic><topic>Free thyroxine (FT 4)</topic><topic>Hexachlorobenzene (HCB)</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>New York</topic><topic>Occupational Exposure - analysis</topic><topic>Polychlorinated biphenyl (PCB)</topic><topic>Polychlorinated Biphenyls - blood</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk Assessment</topic><topic>Thyroid</topic><topic>Thyroid stimulating hormone (TSH)</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bloom, Michael S.</creatorcontrib><creatorcontrib>Vena, John E.</creatorcontrib><creatorcontrib>Olson, James R.</creatorcontrib><creatorcontrib>Kostyniak, Paul J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Pollution Abstracts</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Environment Abstracts</collection><jtitle>International journal of hygiene and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bloom, Michael S.</au><au>Vena, John E.</au><au>Olson, James R.</au><au>Kostyniak, Paul J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York State anglers</atitle><jtitle>International journal of hygiene and environmental health</jtitle><addtitle>Int J Hyg Environ Health</addtitle><date>2009-11-01</date><risdate>2009</risdate><volume>212</volume><issue>6</issue><spage>599</spage><epage>611</epage><pages>599-611</pages><issn>1438-4639</issn><eissn>1618-131X</eissn><abstract>Experimental literature suggests that polychlorinated biphenyls (PCBs) alter thyroid function however studies of non-occupational or acute exposures in human populations have presented equivocal results. This study considered associations between PCBs and thyroid function biomarkers in a specially selected subsample of participants from the New York State Angler Cohort Study, with the goal of hypotheses generation. Between 1995 and 1997, 38 subjects donated a blood specimen and completed a questionnaire. Sera were analyzed for 77 PCB congeners, β-HCH, DDE, HCB, mirex, oxychlordane, and trans-nonachlor using GC-ECD, as well as for lipids components, thyroid stimulating hormone (TSH) and free thyroxine (FT
4).
A priori, the sum of all 77 measured PCB congeners, 27 individual PCB congeners with literature evidence for thyroid effects, their sum, DDE, and HCB were chosen as potential predictors for thyroid function. Age, body mass index, cigarette smoking, gender, and use of thyroid relevant medications were considered as important covariates. Adjusted for log total serum lipids, significant (P<0.05) bivariate correlations were demonstrated for log PCB IUPAC #s 153 (r=0.33), 170 (r=0.38), 171+156 (r=0.36), and 180 (r=0.35) with FT
4; however none were observed for log TSH. Using a forward stepwise selection procedure and confounder evaluation algorithm, log PCB #170 was a significant positive predictor of serum FT
4 (β=1.55 95%CI 0.04-3.07), adjusted for mean centered log PCB #187 and log serum total lipids. This association may be explained by competitive binding to serum thyroid binding proteins by PCB #170, its hydroxylated metabolite 4′-OH-PCB172, or other related but unconsidered compounds. However, bias due to the use of a competitive analog assay for free hormone measurement, random error, or uncontrolled confounding cannot be excluded. The results of this study suggest that Lake Ontario sportfish consumers may comprise a high risk population for PCB related thyroid function alteration and warrant a larger confirmatory investigation.</abstract><cop>München</cop><pub>Elsevier GmbH</pub><pmid>19493696</pmid><doi>10.1016/j.ijheh.2009.04.005</doi><tpages>13</tpages></addata></record> |
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| subjects | Adult Air. Soil. Water. Waste. Feeding Biological and medical sciences Cohort Studies Cross-Sectional Studies Dichlorodiphenyldichloroethylene (DDE) Environment. Living conditions Female Fisheries Free thyroxine (FT 4) Hexachlorobenzene (HCB) Humans Male Medical sciences Miscellaneous New York Occupational Exposure - analysis Polychlorinated biphenyl (PCB) Polychlorinated Biphenyls - blood Public health. Hygiene Public health. Hygiene-occupational medicine Risk Assessment Thyroid Thyroid stimulating hormone (TSH) Thyrotropin - blood Thyroxine - blood Toxicology |
| title | Assessment of polychlorinated biphenyl congeners, thyroid stimulating hormone, and free thyroxine among New York State anglers |
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