Delayed administration of dapsone protects from tissue damage and improves recovery after spinal cord injury

After spinal cord injury (SCI), a complex cascade of pathophysiological processes increases the primary damage. The inflammatory response plays a key role in this pathology. Recent evidence suggests that myeloperoxidase (MPO), an enzyme produced and released by neutrophils, is of special importance...

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Veröffentlicht in:	Journal of neuroscience research 2011-03, Vol.89 (3), p.373-380
Hauptverfasser:	Diaz-Ruiz, Araceli, Salgado-Ceballos, Hermelinda, Montes, Sergio, Guizar-Sahagún, Gabriel, Gelista-Herrera, Noemi, Mendez-Armenta, Marisela, Diaz-Cintra, Sofia, Ríos, Camilo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BBB score dapsone Dapsone - administration & dosage Disease Models, Animal Female Folic Acid Antagonists - administration & dosage lipid peroxidation Lipid Peroxidation - drug effects Motor Activity - drug effects myeloperoxidase neuroprotection Peroxidase - metabolism Rats Rats, Wistar Recovery of Function - drug effects Spinal Cord Injuries - drug therapy Spinal Cord Injuries - pathology Spinal Cord Injuries - physiopathology spinal cord injury Statistics, Nonparametric Survival Analysis Time Factors
Online-Zugang:	Volltext
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